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Stable seroprevalence of Helicobacter pylori infection in children during 1989-1999 in Taipei, Taiwan.
Pediatr Int. 2004 Jun; 46(3):311-4.PI

Abstract

BACKGROUND

Helicobacter pylori (H. pylori) is thought to be acquired in childhood. The present study aimed to examine the changing seroepidemiology of H. pylori in children in the same area of Taipei city during 1989-1999, and to try to elucidate the possible transmission route of H. pylori in children by comparing hepatitis A virus (HAV) seroprevalence in Taipei during the same decade.

METHODS

Sera were collected from the apparently healthy children (965 males and 835 females, aged 0-20 years) from the Chung Cheng District of Taipei city. H. pylori infection status was checked by enzyme-linked immunosorbent assay (ELISA).

RESULTS

In 1999, the overall prevalence rate of H. pylori infection was 14.8% with no gender difference (P = 0.115). Children aged 1-3 years had the lowest prevalence rate (2.8%). The prevalence rate then increased steadily after 3 years of age. The annual infection rate was 1.25% after 3 years of age and the seroprevalence rate was 21.5% at 15-18 years. In comparison with the previous H. pylori seroepidemiology study performed at the same district of Taipei city one decade ago, there is no significant cohort effect in H. pylori prevalence in Taipei children during the past decade (Odds ratio = 1.13; 95% confidence interval: 0.74-1.72). The epidemiological pattern between H. pylori and HAV was found to be different.

CONCLUSION

The seroprevalence of H. pylori in children did not change significantly in the past decade. This epidemiological feature is different from HAV. The authors propose that there are other transmission routes of H. pylori than fecal-oral.

Authors+Show Affiliations

Lee IH
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Ni YH
No affiliation info available
Chang MH
No affiliation info available

MeSH

AdolescentChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleHelicobacter InfectionsHelicobacter pyloriHepatitis AHumansInfantInfant, NewbornMaleSeroepidemiologic StudiesTaiwan

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15151548

Citation

Lee, I-Hsien, et al. "Stable Seroprevalence of Helicobacter Pylori Infection in Children During 1989-1999 in Taipei, Taiwan." Pediatrics International : Official Journal of the Japan Pediatric Society, vol. 46, no. 3, 2004, pp. 311-4.
Lee IH, Ni YH, Chang MH. Stable seroprevalence of Helicobacter pylori infection in children during 1989-1999 in Taipei, Taiwan. Pediatr Int. 2004;46(3):311-4.
Lee, I. H., Ni, Y. H., & Chang, M. H. (2004). Stable seroprevalence of Helicobacter pylori infection in children during 1989-1999 in Taipei, Taiwan. Pediatrics International : Official Journal of the Japan Pediatric Society, 46(3), 311-4.
Lee IH, Ni YH, Chang MH. Stable Seroprevalence of Helicobacter Pylori Infection in Children During 1989-1999 in Taipei, Taiwan. Pediatr Int. 2004;46(3):311-4. PubMed PMID: 15151548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stable seroprevalence of Helicobacter pylori infection in children during 1989-1999 in Taipei, Taiwan. AU - Lee,I-Hsien, AU - Ni,Yen-Hsuan, AU - Chang,Mei-Hwei, PY - 2004/5/21/pubmed PY - 2004/7/3/medline PY - 2004/5/21/entrez SP - 311 EP - 4 JF - Pediatrics international : official journal of the Japan Pediatric Society JO - Pediatr Int VL - 46 IS - 3 N2 - BACKGROUND: Helicobacter pylori (H. pylori) is thought to be acquired in childhood. The present study aimed to examine the changing seroepidemiology of H. pylori in children in the same area of Taipei city during 1989-1999, and to try to elucidate the possible transmission route of H. pylori in children by comparing hepatitis A virus (HAV) seroprevalence in Taipei during the same decade. METHODS: Sera were collected from the apparently healthy children (965 males and 835 females, aged 0-20 years) from the Chung Cheng District of Taipei city. H. pylori infection status was checked by enzyme-linked immunosorbent assay (ELISA). RESULTS: In 1999, the overall prevalence rate of H. pylori infection was 14.8% with no gender difference (P = 0.115). Children aged 1-3 years had the lowest prevalence rate (2.8%). The prevalence rate then increased steadily after 3 years of age. The annual infection rate was 1.25% after 3 years of age and the seroprevalence rate was 21.5% at 15-18 years. In comparison with the previous H. pylori seroepidemiology study performed at the same district of Taipei city one decade ago, there is no significant cohort effect in H. pylori prevalence in Taipei children during the past decade (Odds ratio = 1.13; 95% confidence interval: 0.74-1.72). The epidemiological pattern between H. pylori and HAV was found to be different. CONCLUSION: The seroprevalence of H. pylori in children did not change significantly in the past decade. This epidemiological feature is different from HAV. The authors propose that there are other transmission routes of H. pylori than fecal-oral. SN - 1328-8067 UR - https://www.unboundmedicine.com/medline/citation/15151548/Stable_seroprevalence_of_Helicobacter_pylori_infection_in_children_during_1989_1999_in_Taipei_Taiwan_ DB - PRIME DP - Unbound Medicine ER -