Tags

Type your tag names separated by a space and hit enter

[Dementia and cognitive impairment pattern: its association with epsilon4 allele of apolipoprotein E gene].
Rev Neurol 2004 May 1-15; 38(9):801-7RN

Abstract

INTRODUCTION

The APOE epsilon4 allele is a well-established risk factor for Alzheimer's disease. This disease is characterized by a typical progressive cognitive impairment pattern, different from that of other primary dementias such as dementia with Lewy bodies or frontotemporal and vascular dementias, for which there are no conclusive results on the influence of the APOE genotype.

OBJECTIVE

Our aim is to study how the APOE genotype associates with different dementia types, and the association of this genotype with mild cognitive impairment and age related cognitive decline, which might be stages in a continuum between normality and dementia.

PATIENTS AND METHODS

From a group of 1,022 people we selected 733 patients with different dementia diagnosis and 205 controls. APOE genotype for each participant in the study was determined.

RESULTS

As it was already known, the epsilon4 allele is associated to senile Alzheimer's disease (OR= 5.6; 95% CI= 3.6-8.9; p< 0.001) and presenile Alzheimer's disease (OR= 5.4; 95% CI= 2.1-13.8; p< 0.001). It is also associated to mild cognitive impairment (OR= 3.7; 95% CI= 2.3-6.0; p< 0.001) and to age related cognitive decline (OR= 3.0; 95% CI= 1.2-7.3; p< 0.01). Female Alzheimer patients with at least one epsilon4 allele present significantly an earlier age at onset (epsilon4+= 73.4 +/- 5.4; epsilon4- = 76.9 +/- 5.5; p< 0.001).

CONCLUSION

The APOE genotype is associated to Alzheimer's disease and to its cognitive impairment pattern. This association has a growing value according to the degree of clinical impairment. The APOE genotype could be used in differential diagnostic of cognitive impairment.

Authors+Show Affiliations

Hospital Psiquiàtric, Universitari Institut Pere Mata, Reus, Tarragona, Spain. rosichm@peremata.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

15152345

Citation

Rosich-Estragó, M, et al. "[Dementia and Cognitive Impairment Pattern: Its Association With Epsilon4 Allele of Apolipoprotein E Gene]." Revista De Neurologia, vol. 38, no. 9, 2004, pp. 801-7.
Rosich-Estragó M, Figuera-Terré L, Mulet-Pérez B, et al. [Dementia and cognitive impairment pattern: its association with epsilon4 allele of apolipoprotein E gene]. Rev Neurol. 2004;38(9):801-7.
Rosich-Estragó, M., Figuera-Terré, L., Mulet-Pérez, B., Arrufat-Cardús, M. T., Pascual San Emeterio, A., Arbeola-Rigau, I., ... Vilella-Cuadrada, E. (2004). [Dementia and cognitive impairment pattern: its association with epsilon4 allele of apolipoprotein E gene]. Revista De Neurologia, 38(9), pp. 801-7.
Rosich-Estragó M, et al. [Dementia and Cognitive Impairment Pattern: Its Association With Epsilon4 Allele of Apolipoprotein E Gene]. Rev Neurol. 2004;38(9):801-7. PubMed PMID: 15152345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dementia and cognitive impairment pattern: its association with epsilon4 allele of apolipoprotein E gene]. AU - Rosich-Estragó,M, AU - Figuera-Terré,L, AU - Mulet-Pérez,B, AU - Arrufat-Cardús,M T, AU - Pascual San Emeterio,A, AU - Arbeola-Rigau,I, AU - Labad-Alquézar,A, AU - Vilella-Cuadrada,E, PY - 2004/5/21/pubmed PY - 2004/9/25/medline PY - 2004/5/21/entrez SP - 801 EP - 7 JF - Revista de neurologia JO - Rev Neurol VL - 38 IS - 9 N2 - INTRODUCTION: The APOE epsilon4 allele is a well-established risk factor for Alzheimer's disease. This disease is characterized by a typical progressive cognitive impairment pattern, different from that of other primary dementias such as dementia with Lewy bodies or frontotemporal and vascular dementias, for which there are no conclusive results on the influence of the APOE genotype. OBJECTIVE: Our aim is to study how the APOE genotype associates with different dementia types, and the association of this genotype with mild cognitive impairment and age related cognitive decline, which might be stages in a continuum between normality and dementia. PATIENTS AND METHODS: From a group of 1,022 people we selected 733 patients with different dementia diagnosis and 205 controls. APOE genotype for each participant in the study was determined. RESULTS: As it was already known, the epsilon4 allele is associated to senile Alzheimer's disease (OR= 5.6; 95% CI= 3.6-8.9; p< 0.001) and presenile Alzheimer's disease (OR= 5.4; 95% CI= 2.1-13.8; p< 0.001). It is also associated to mild cognitive impairment (OR= 3.7; 95% CI= 2.3-6.0; p< 0.001) and to age related cognitive decline (OR= 3.0; 95% CI= 1.2-7.3; p< 0.01). Female Alzheimer patients with at least one epsilon4 allele present significantly an earlier age at onset (epsilon4+= 73.4 +/- 5.4; epsilon4- = 76.9 +/- 5.5; p< 0.001). CONCLUSION: The APOE genotype is associated to Alzheimer's disease and to its cognitive impairment pattern. This association has a growing value according to the degree of clinical impairment. The APOE genotype could be used in differential diagnostic of cognitive impairment. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/15152345/[Dementia_and_cognitive_impairment_pattern:_its_association_with_epsilon4_allele_of_apolipoprotein_E_gene]_ L2 - http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2003336&amp;Revista=Revneurol DB - PRIME DP - Unbound Medicine ER -