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Prophylactic efficacy of allopurinol ice ball for leucovorin/5-fluorouracil therapy-induced stomatitis.
Anticancer Res. 2004 Mar-Apr; 24(2C):1131-4.AR

Abstract

BACKGROUND

Stomatitis in cancer chemotherapy manifests with pronounced subjective symptoms, lowers the patient's quality of life (QOL) and may necessitate the discontinuation of chemotherapy. There have been few effective therapies established to date for chemotherapy-induced stomatitis.

PATIENTS AND METHODS

We used frozen allopurinol solution (allopurinol ice balls) in the prevention of stomatitis associated with leucovorin (LV)/5-fluorouracil (5-FU) therapy for colon cancer.

RESULTS

Among 32 patients undergoing LV/5-FU therapy, without the use of the allopurinol ice balls, 15 patients developed stomatitis. On the other hand, only 3 patients developed stomatitis among 20 patients receiving the chemotherapy in conjunction with allopurinol ice balls (p=0.0187). Seven patients who developed stomatitis during a course of chemotherapy without allopurinol ice balls were administered the ice balls in the subsequent course; 6 of these patients responded with lessened severity of stomatitis. In 2 of these responders, stomatitis of comparable severity recurred on discontinuation of the medication.

CONCLUSION

Concomitant use of allopurinol ice balls is effective in preventing stomatitis in patients undergoing LV/5-FU therapy.

Authors+Show Affiliations

Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishiogu, Arakawaku, Tokyo, Japan 116-8567.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15154636

Citation

Yokomizo, Hajime, et al. "Prophylactic Efficacy of Allopurinol Ice Ball for Leucovorin/5-fluorouracil Therapy-induced Stomatitis." Anticancer Research, vol. 24, no. 2C, 2004, pp. 1131-4.
Yokomizo H, Yoshimatsu K, Hashimoto M, et al. Prophylactic efficacy of allopurinol ice ball for leucovorin/5-fluorouracil therapy-induced stomatitis. Anticancer Res. 2004;24(2C):1131-4.
Yokomizo, H., Yoshimatsu, K., Hashimoto, M., Ishibashi, K., Umehara, A., Yoshida, K., Fujimoto, T., Watanabe, K., & Ogawa, K. (2004). Prophylactic efficacy of allopurinol ice ball for leucovorin/5-fluorouracil therapy-induced stomatitis. Anticancer Research, 24(2C), 1131-4.
Yokomizo H, et al. Prophylactic Efficacy of Allopurinol Ice Ball for Leucovorin/5-fluorouracil Therapy-induced Stomatitis. Anticancer Res. 2004;24(2C):1131-4. PubMed PMID: 15154636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylactic efficacy of allopurinol ice ball for leucovorin/5-fluorouracil therapy-induced stomatitis. AU - Yokomizo,Hajime, AU - Yoshimatsu,Kazuhiko, AU - Hashimoto,Masahiko, AU - Ishibashi,Keiichiro, AU - Umehara,Arihiro, AU - Yoshida,Kiyohito, AU - Fujimoto,Takashi, AU - Watanabe,Kiyo, AU - Ogawa,Kenji, PY - 2004/5/25/pubmed PY - 2004/6/25/medline PY - 2004/5/25/entrez SP - 1131 EP - 4 JF - Anticancer research JO - Anticancer Res. VL - 24 IS - 2C N2 - BACKGROUND: Stomatitis in cancer chemotherapy manifests with pronounced subjective symptoms, lowers the patient's quality of life (QOL) and may necessitate the discontinuation of chemotherapy. There have been few effective therapies established to date for chemotherapy-induced stomatitis. PATIENTS AND METHODS: We used frozen allopurinol solution (allopurinol ice balls) in the prevention of stomatitis associated with leucovorin (LV)/5-fluorouracil (5-FU) therapy for colon cancer. RESULTS: Among 32 patients undergoing LV/5-FU therapy, without the use of the allopurinol ice balls, 15 patients developed stomatitis. On the other hand, only 3 patients developed stomatitis among 20 patients receiving the chemotherapy in conjunction with allopurinol ice balls (p=0.0187). Seven patients who developed stomatitis during a course of chemotherapy without allopurinol ice balls were administered the ice balls in the subsequent course; 6 of these patients responded with lessened severity of stomatitis. In 2 of these responders, stomatitis of comparable severity recurred on discontinuation of the medication. CONCLUSION: Concomitant use of allopurinol ice balls is effective in preventing stomatitis in patients undergoing LV/5-FU therapy. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/15154636/Prophylactic_efficacy_of_allopurinol_ice_ball_for_leucovorin/5_fluorouracil_therapy_induced_stomatitis_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=15154636 DB - PRIME DP - Unbound Medicine ER -