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Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C.
Diabet Med. 2004 Jun; 21(6):552-8.DM

Abstract

AIMS

Type 2 diabetes mellitus (DM) and coronary artery disease (CAD) are both associated with endothelial dysfunction and elevated oxidative and inflammatory state. We examined the effect of vitamin C on endothelial function and levels of soluble vascular cell adhesion molecule (sVCAM-1), interleukin-6 (IL-6) and tumour necrosis factor (TNF-alpha), in DM patients with or without CAD and in non-diabetic subjects.

METHODS

Thirty-seven patients with DM + CAD, 17 patients with DM without CAD and 21 non-diabetic subjects were divided into groups receiving vitamin C 2 g/day or no anti-oxidant for 4 weeks. Forearm blood flow was determined using venous occlusion gauge-strain plethysmography. Forearm vasodilatory response to reactive hyperemia was considered as index of endothelium-dependent dilation.

RESULTS

Baseline levels of IL-6 and TNF-alpha were significantly higher in patients with DM + CAD compared with patients with DM (P < 0.01) or non-diabetic subjects (P < 0.01). IL-6 and TNF-alpha levels were also higher in DM compared with non-diabetic subjects (P < 0.05). sVCAM-1 levels were lower in non-diabetic controls compared with DM + CAD (P < 0.05) or DM (P < 0.05). Reactive hyperaemia was higher in non-diabetic controls compared with DM + CAD (P < 0.001) or DM (P < 0.001). Vitamin C significantly increased reactive hyperaemia only in the DM + CAD group, while it had no effect on serum levels of sVCAM-1, TNF-alpha and IL-6 in any of the groups.

CONCLUSIONS

Type 2 diabetes mellitus is associated with impaired endothelial function and increased levels of TNF-alpha, IL-6 and sVCAM-1, especially in patients with DM and CAD. Vitamin C significantly increased forearm vasodilatory response to reactive hyperaemia only in patients with combined DM and CAD.

Authors+Show Affiliations

Cardiology Department, Athens University Medical School, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15154938

Citation

Antoniades, C, et al. "Vascular Endothelium and Inflammatory Process, in Patients With Combined Type 2 Diabetes Mellitus and Coronary Atherosclerosis: the Effects of Vitamin C." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 21, no. 6, 2004, pp. 552-8.
Antoniades C, Tousoulis D, Tountas C, et al. Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. Diabet Med. 2004;21(6):552-8.
Antoniades, C., Tousoulis, D., Tountas, C., Tentolouris, C., Toutouza, M., Vasiliadou, C., Tsioufis, C., Toutouzas, P., & Stefanadis, C. (2004). Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. Diabetic Medicine : a Journal of the British Diabetic Association, 21(6), 552-8.
Antoniades C, et al. Vascular Endothelium and Inflammatory Process, in Patients With Combined Type 2 Diabetes Mellitus and Coronary Atherosclerosis: the Effects of Vitamin C. Diabet Med. 2004;21(6):552-8. PubMed PMID: 15154938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. AU - Antoniades,C, AU - Tousoulis,D, AU - Tountas,C, AU - Tentolouris,C, AU - Toutouza,M, AU - Vasiliadou,C, AU - Tsioufis,C, AU - Toutouzas,P, AU - Stefanadis,C, PY - 2004/5/25/pubmed PY - 2004/8/31/medline PY - 2004/5/25/entrez SP - 552 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 21 IS - 6 N2 - AIMS: Type 2 diabetes mellitus (DM) and coronary artery disease (CAD) are both associated with endothelial dysfunction and elevated oxidative and inflammatory state. We examined the effect of vitamin C on endothelial function and levels of soluble vascular cell adhesion molecule (sVCAM-1), interleukin-6 (IL-6) and tumour necrosis factor (TNF-alpha), in DM patients with or without CAD and in non-diabetic subjects. METHODS: Thirty-seven patients with DM + CAD, 17 patients with DM without CAD and 21 non-diabetic subjects were divided into groups receiving vitamin C 2 g/day or no anti-oxidant for 4 weeks. Forearm blood flow was determined using venous occlusion gauge-strain plethysmography. Forearm vasodilatory response to reactive hyperemia was considered as index of endothelium-dependent dilation. RESULTS: Baseline levels of IL-6 and TNF-alpha were significantly higher in patients with DM + CAD compared with patients with DM (P < 0.01) or non-diabetic subjects (P < 0.01). IL-6 and TNF-alpha levels were also higher in DM compared with non-diabetic subjects (P < 0.05). sVCAM-1 levels were lower in non-diabetic controls compared with DM + CAD (P < 0.05) or DM (P < 0.05). Reactive hyperaemia was higher in non-diabetic controls compared with DM + CAD (P < 0.001) or DM (P < 0.001). Vitamin C significantly increased reactive hyperaemia only in the DM + CAD group, while it had no effect on serum levels of sVCAM-1, TNF-alpha and IL-6 in any of the groups. CONCLUSIONS: Type 2 diabetes mellitus is associated with impaired endothelial function and increased levels of TNF-alpha, IL-6 and sVCAM-1, especially in patients with DM and CAD. Vitamin C significantly increased forearm vasodilatory response to reactive hyperaemia only in patients with combined DM and CAD. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15154938/Vascular_endothelium_and_inflammatory_process_in_patients_with_combined_Type_2_diabetes_mellitus_and_coronary_atherosclerosis:_the_effects_of_vitamin_C_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=15154938.ui DB - PRIME DP - Unbound Medicine ER -