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Strong association of C-reactive protein with body mass index and 2-h post-challenge glucose in non-diabetic, non-smoker subjects without hypertension.
Diabet Med. 2004 Jun; 21(6):581-5.DM

Abstract

AIMS

Increases in C-reactive protein (CRP) levels have been shown to be associated with cardiovascular diseases as well as asymptomatic atherosclerosis and to be closely related to traditional cardiovascular risk factors. The aim of this study was to determine the clinical and biochemical characteristics associated with CRP in non-diabetic, non-smoker subjects without hypertension.

METHODS

A 75-g oral glucose tolerance test was performed on 305 Japanese subjects aged 40-70 years who were undergoing health examinations. We recruited non-diabetic, non-smoker subjects without hypertension. Subjects with known cardiovascular diseases, chronic or acute inflammation, malignant diseases, or autoimmune disorders were excluded. Plasma high-sensitivity CRP was measured in 125 subjects who satisfied the admission criteria.

RESULTS

Plasma CRP levels were significantly higher in the 28 subjects with impaired glucose tolerance (IGT) than that in the 97 subjects with normal glucose tolerance (NGT) (median 0.53, range 0.18-1.10 mg/l vs. median 0.32, range 0.17-0.49 mg/l; P = 0.032). There was a positive correlation of CRP with body mass index (BMI), triglycerides, uric acid, fasting glucose, oral glucose tolerance test (OGTT) 1-h glucose, OGTT 2-h glucose, and a negative correlation with HDL cholesterol. Multivariate regression analysis identified BMI (F = 8.57, P = 0.004) and OGTT 2-h glucose (F = 5.96, P = 0.016) as independent predictors for CRP.

CONCLUSIONS

BMI and OGTT 2-h glucose are the most important predictors for plasma CRP in non-diabetic, non-smoker subjects without hypertension.

Authors+Show Affiliations

Department of Internal Medicine, Kinki Central Hospital, Itami, Hyogo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15154943

Citation

Hashimoto, K, et al. "Strong Association of C-reactive Protein With Body Mass Index and 2-h Post-challenge Glucose in Non-diabetic, Non-smoker Subjects Without Hypertension." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 21, no. 6, 2004, pp. 581-5.
Hashimoto K, Kasayama S, Yamamoto H, et al. Strong association of C-reactive protein with body mass index and 2-h post-challenge glucose in non-diabetic, non-smoker subjects without hypertension. Diabet Med. 2004;21(6):581-5.
Hashimoto, K., Kasayama, S., Yamamoto, H., Kurebayashi, S., Kawase, I., & Koga, M. (2004). Strong association of C-reactive protein with body mass index and 2-h post-challenge glucose in non-diabetic, non-smoker subjects without hypertension. Diabetic Medicine : a Journal of the British Diabetic Association, 21(6), 581-5.
Hashimoto K, et al. Strong Association of C-reactive Protein With Body Mass Index and 2-h Post-challenge Glucose in Non-diabetic, Non-smoker Subjects Without Hypertension. Diabet Med. 2004;21(6):581-5. PubMed PMID: 15154943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strong association of C-reactive protein with body mass index and 2-h post-challenge glucose in non-diabetic, non-smoker subjects without hypertension. AU - Hashimoto,K, AU - Kasayama,S, AU - Yamamoto,H, AU - Kurebayashi,S, AU - Kawase,I, AU - Koga,M, PY - 2004/5/25/pubmed PY - 2004/8/31/medline PY - 2004/5/25/entrez SP - 581 EP - 5 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 21 IS - 6 N2 - AIMS: Increases in C-reactive protein (CRP) levels have been shown to be associated with cardiovascular diseases as well as asymptomatic atherosclerosis and to be closely related to traditional cardiovascular risk factors. The aim of this study was to determine the clinical and biochemical characteristics associated with CRP in non-diabetic, non-smoker subjects without hypertension. METHODS: A 75-g oral glucose tolerance test was performed on 305 Japanese subjects aged 40-70 years who were undergoing health examinations. We recruited non-diabetic, non-smoker subjects without hypertension. Subjects with known cardiovascular diseases, chronic or acute inflammation, malignant diseases, or autoimmune disorders were excluded. Plasma high-sensitivity CRP was measured in 125 subjects who satisfied the admission criteria. RESULTS: Plasma CRP levels were significantly higher in the 28 subjects with impaired glucose tolerance (IGT) than that in the 97 subjects with normal glucose tolerance (NGT) (median 0.53, range 0.18-1.10 mg/l vs. median 0.32, range 0.17-0.49 mg/l; P = 0.032). There was a positive correlation of CRP with body mass index (BMI), triglycerides, uric acid, fasting glucose, oral glucose tolerance test (OGTT) 1-h glucose, OGTT 2-h glucose, and a negative correlation with HDL cholesterol. Multivariate regression analysis identified BMI (F = 8.57, P = 0.004) and OGTT 2-h glucose (F = 5.96, P = 0.016) as independent predictors for CRP. CONCLUSIONS: BMI and OGTT 2-h glucose are the most important predictors for plasma CRP in non-diabetic, non-smoker subjects without hypertension. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15154943/Strong_association_of_C_reactive_protein_with_body_mass_index_and_2_h_post_challenge_glucose_in_non_diabetic_non_smoker_subjects_without_hypertension_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15154943.ui DB - PRIME DP - Unbound Medicine ER -