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Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy.
Angiology 2004 May-Jun; 55(3):281-8A

Abstract

Increased intima-media thickness (IMT) in the common carotid artery (CCA) correlates with conventional risk factors for cardiovascular disease and is an independent predictor of cardiac events. However, correlation between IMT and degree of ischemic heart disease evaluated by coronary angiogram is weak. The purpose of this study was to investigate the relationship between measures of carotid atherosclerosis and the extent and severity of coronary artery disease (CAD) in 111 consecutive patients (60 men and 51 women, mean age 60 years) with known or suspected CAD who were investigated with adenosine-stress myocardial perfusion scintigraphy. Common carotid artery lumen diameter (LD) and IMT of the carotid bulb and distal CCA were measured with ultrasound, and CCA cross-sectional intima-media area (CIMA) was calculated. Seventy-two of 110 patients (65%) had significant perfusion defects. Increasing carotid plaque occurrence (absence, unilateral or bilateral occurrence) correlated with more advanced CAD (p<0.01). The extent and severity of myocardial hypoperfusion correlated significantly with presence of carotid plaque (r=0.23 and 0.24 respectively, p<0.05), CIMA (r=0.23 and 0.22, p<0.05), and LD (r<0.26 and 0.25, p<0.01) but not with IMT. In contrast to CIMA, LD failed to show an independent relation to extent of CAD after adjustment for age, sex, and body mass index. In conclusion, in subjects with intermediate to high risk of ischemic heart disease, occurrence of carotid plaques and increased cross-sectional intimamedia area in the common carotid artery are the best parameters for predicting CAD expressed as myocardial hypoperfusion.

Authors+Show Affiliations

Karolinska Institute, Department of Clinical Physiology at Stockholm Söder Hospital, Stockholm, Sweden. staffan.hallerstam@telia.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15156261

Citation

Hallerstam, Staffan, et al. "Carotid Atherosclerosis Is Correlated With Extent and Severity of Coronary Artery Disease Evaluated By Myocardial Perfusion Scintigraphy." Angiology, vol. 55, no. 3, 2004, pp. 281-8.
Hallerstam S, Larsson PT, Zuber E, et al. Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy. Angiology. 2004;55(3):281-8.
Hallerstam, S., Larsson, P. T., Zuber, E., & Rosfors, S. (2004). Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy. Angiology, 55(3), pp. 281-8.
Hallerstam S, et al. Carotid Atherosclerosis Is Correlated With Extent and Severity of Coronary Artery Disease Evaluated By Myocardial Perfusion Scintigraphy. Angiology. 2004;55(3):281-8. PubMed PMID: 15156261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy. AU - Hallerstam,Staffan, AU - Larsson,P Thomas, AU - Zuber,Ernst, AU - Rosfors,Stefan, PY - 2004/5/25/pubmed PY - 2004/6/25/medline PY - 2004/5/25/entrez SP - 281 EP - 8 JF - Angiology JO - Angiology VL - 55 IS - 3 N2 - Increased intima-media thickness (IMT) in the common carotid artery (CCA) correlates with conventional risk factors for cardiovascular disease and is an independent predictor of cardiac events. However, correlation between IMT and degree of ischemic heart disease evaluated by coronary angiogram is weak. The purpose of this study was to investigate the relationship between measures of carotid atherosclerosis and the extent and severity of coronary artery disease (CAD) in 111 consecutive patients (60 men and 51 women, mean age 60 years) with known or suspected CAD who were investigated with adenosine-stress myocardial perfusion scintigraphy. Common carotid artery lumen diameter (LD) and IMT of the carotid bulb and distal CCA were measured with ultrasound, and CCA cross-sectional intima-media area (CIMA) was calculated. Seventy-two of 110 patients (65%) had significant perfusion defects. Increasing carotid plaque occurrence (absence, unilateral or bilateral occurrence) correlated with more advanced CAD (p<0.01). The extent and severity of myocardial hypoperfusion correlated significantly with presence of carotid plaque (r=0.23 and 0.24 respectively, p<0.05), CIMA (r=0.23 and 0.22, p<0.05), and LD (r<0.26 and 0.25, p<0.01) but not with IMT. In contrast to CIMA, LD failed to show an independent relation to extent of CAD after adjustment for age, sex, and body mass index. In conclusion, in subjects with intermediate to high risk of ischemic heart disease, occurrence of carotid plaques and increased cross-sectional intimamedia area in the common carotid artery are the best parameters for predicting CAD expressed as myocardial hypoperfusion. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/15156261/Carotid_atherosclerosis_is_correlated_with_extent_and_severity_of_coronary_artery_disease_evaluated_by_myocardial_perfusion_scintigraphy_ L2 - http://journals.sagepub.com/doi/full/10.1177/000331970405500307?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -