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Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the Asian Network for Surveillance of Resistant Pathogens.
Clin Infect Dis. 2004 Jun 01; 38(11):1570-8.CI

Abstract

To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were not susceptible to penicillin (25.3% were intermediately susceptible, and 29.6% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance.

Authors+Show Affiliations

Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jhsong@ansorp.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15156445

Citation

Song, Jae-Hoon, et al. "Clinical Outcomes of Pneumococcal Pneumonia Caused By Antibiotic-resistant Strains in Asian Countries: a Study By the Asian Network for Surveillance of Resistant Pathogens." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 38, no. 11, 2004, pp. 1570-8.
Song JH, Jung SI, Ki HK, et al. Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the Asian Network for Surveillance of Resistant Pathogens. Clin Infect Dis. 2004;38(11):1570-8.
Song, J. H., Jung, S. I., Ki, H. K., Shin, M. H., Ko, K. S., Son, J. S., Chang, H. H., Kim, S. W., Lee, H., Kim, Y. S., Oh, W. S., Peck, K. R., Chongthaleong, A., Lalitha, M. K., Perera, J., Yee, T. T., Jamal, F., Kamarulzaman, A., Carlos, C. C., & So, T. (2004). Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the Asian Network for Surveillance of Resistant Pathogens. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 38(11), 1570-8.
Song JH, et al. Clinical Outcomes of Pneumococcal Pneumonia Caused By Antibiotic-resistant Strains in Asian Countries: a Study By the Asian Network for Surveillance of Resistant Pathogens. Clin Infect Dis. 2004 Jun 1;38(11):1570-8. PubMed PMID: 15156445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the Asian Network for Surveillance of Resistant Pathogens. AU - Song,Jae-Hoon, AU - Jung,Sook-In, AU - Ki,Hyun Kyun, AU - Shin,Myung-Hee, AU - Ko,Kwan Soo, AU - Son,Jun Seong, AU - Chang,Hyun-Ha, AU - Kim,Shin Woo, AU - Lee,Hyuck, AU - Kim,Yeon-Sook, AU - Oh,Won Sup, AU - Peck,Kyong Ran, AU - Chongthaleong,Anan, AU - Lalitha,M K, AU - Perera,Jennifer, AU - Yee,Ti Teow, AU - Jamal,Farida, AU - Kamarulzaman,Adeeba, AU - Carlos,Celia C, AU - So,Thomas, AU - ,, Y1 - 2004/05/13/ PY - 2003/11/14/received PY - 2004/01/28/accepted PY - 2004/5/25/pubmed PY - 2004/8/21/medline PY - 2004/5/25/entrez SP - 1570 EP - 8 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 38 IS - 11 N2 - To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were not susceptible to penicillin (25.3% were intermediately susceptible, and 29.6% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15156445/Clinical_outcomes_of_pneumococcal_pneumonia_caused_by_antibiotic_resistant_strains_in_asian_countries:_a_study_by_the_Asian_Network_for_Surveillance_of_Resistant_Pathogens_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/420821 DB - PRIME DP - Unbound Medicine ER -