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Longitudinal assessment of psychopathological domains over late-stage schizophrenia in relation to duration of initially untreated psychosis: 3-year prospective study in a long-term inpatient population.
Psychiatry Res. 2004 May 30; 126(3):217-27.PR

Abstract

There remains uncertainty regarding any progressive nature of psychopathology and cognitive dysfunction in late-stage schizophrenia, and whether duration of initially untreated psychosis (DUP) might be associated with such 'progression'. This study examines longitudinally, over 3 years, the psychopathology and neuropsychology in 82 inpatients with DSM-IV schizophrenia, many of whom were admitted in the pre-neuroleptic era. Increase in executive dysfunction exceeded that in general cognitive impairment. Positive but not negative symptom severity decreased modestly; the primary predictor of negative symptom severity was DUP. On index assessment, psychopathology evidenced a three-factor structure; at follow-up, psychomotor poverty evidenced greater prominence and cohesion, and was on both occasions predicted primarily by DUP, while reality distortion was altered and disorganisation disassembled into alternative elements. It would appear that as years of chronic, refractory illness accrue, psychomotor poverty becomes more sharply delineated and dominant within the overall structure of psychopathology, and its prominence is predicted enduringly by DUP.

Authors+Show Affiliations

Department of Psychiatry, Midwestern Regional Hospital, Limerick, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15157748

Citation

Meagher, David J., et al. "Longitudinal Assessment of Psychopathological Domains Over Late-stage Schizophrenia in Relation to Duration of Initially Untreated Psychosis: 3-year Prospective Study in a Long-term Inpatient Population." Psychiatry Research, vol. 126, no. 3, 2004, pp. 217-27.
Meagher DJ, Quinn JF, Bourke S, et al. Longitudinal assessment of psychopathological domains over late-stage schizophrenia in relation to duration of initially untreated psychosis: 3-year prospective study in a long-term inpatient population. Psychiatry Res. 2004;126(3):217-27.
Meagher, D. J., Quinn, J. F., Bourke, S., Linehan, S., Murphy, P., Kinsella, A., Mullaney, J., & Waddington, J. L. (2004). Longitudinal assessment of psychopathological domains over late-stage schizophrenia in relation to duration of initially untreated psychosis: 3-year prospective study in a long-term inpatient population. Psychiatry Research, 126(3), 217-27.
Meagher DJ, et al. Longitudinal Assessment of Psychopathological Domains Over Late-stage Schizophrenia in Relation to Duration of Initially Untreated Psychosis: 3-year Prospective Study in a Long-term Inpatient Population. Psychiatry Res. 2004 May 30;126(3):217-27. PubMed PMID: 15157748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal assessment of psychopathological domains over late-stage schizophrenia in relation to duration of initially untreated psychosis: 3-year prospective study in a long-term inpatient population. AU - Meagher,David J, AU - Quinn,John F, AU - Bourke,Stephanie, AU - Linehan,Sally, AU - Murphy,Patrice, AU - Kinsella,Anthony, AU - Mullaney,James, AU - Waddington,John L, PY - 2003/07/02/received PY - 2004/02/02/revised PY - 2004/02/19/accepted PY - 2004/5/26/pubmed PY - 2004/9/24/medline PY - 2004/5/26/entrez SP - 217 EP - 27 JF - Psychiatry research JO - Psychiatry Res VL - 126 IS - 3 N2 - There remains uncertainty regarding any progressive nature of psychopathology and cognitive dysfunction in late-stage schizophrenia, and whether duration of initially untreated psychosis (DUP) might be associated with such 'progression'. This study examines longitudinally, over 3 years, the psychopathology and neuropsychology in 82 inpatients with DSM-IV schizophrenia, many of whom were admitted in the pre-neuroleptic era. Increase in executive dysfunction exceeded that in general cognitive impairment. Positive but not negative symptom severity decreased modestly; the primary predictor of negative symptom severity was DUP. On index assessment, psychopathology evidenced a three-factor structure; at follow-up, psychomotor poverty evidenced greater prominence and cohesion, and was on both occasions predicted primarily by DUP, while reality distortion was altered and disorganisation disassembled into alternative elements. It would appear that as years of chronic, refractory illness accrue, psychomotor poverty becomes more sharply delineated and dominant within the overall structure of psychopathology, and its prominence is predicted enduringly by DUP. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/15157748/Longitudinal_assessment_of_psychopathological_domains_over_late_stage_schizophrenia_in_relation_to_duration_of_initially_untreated_psychosis:_3_year_prospective_study_in_a_long_term_inpatient_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165178104000575 DB - PRIME DP - Unbound Medicine ER -