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Non-selective opioid receptor antagonism of the antidepressant-like effect of venlafaxine in the forced swimming test in mice.
Neurosci Lett. 2004 Jun 03; 363(1):25-8.NL

Abstract

The opioid system has been implicated in mood disorders as well as in the mechanism of action of antidepressants. Since the opioid component in venlafaxine (VLX) is still a matter of discussion, we investigated the role of opioid receptors in the antidepressant-like effect of VLX in the forced swimming test in mice. The non-selective opiate antagonist naloxone at high dose (2 mg/kg, s.c.) antagonized the effect of VLX. In contrast, beta-funaltrexamine (40 mg/kg, s.c.), which preferentially blocks mu(1)/mu(2) opioid receptors, naloxonazine (35 mg/kg, s.c.), a selective mu(1) opioid antagonist, naltrindole (10 mg/kg, s.c.), a selective delta opioid antagonist, and Nor-binaltorphimine (10 mg/kg, s.c.), which selectively blocks kappa-opioid receptors, were all ineffective. Thus, although apparently mediated by the opioid system, the behavioural effect of VLX does not involve specific opioid receptors.

Authors+Show Affiliations

Pharmacology and Neuroscience Research Group (PAI-510), Department of Neuroscience (Pharmacology and Psychiatry), Faculty of Medicine, University of Cádiz, Plaza Falla, 9, 11003 Cadiz, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15157989

Citation

Berrocoso, Esther, et al. "Non-selective Opioid Receptor Antagonism of the Antidepressant-like Effect of Venlafaxine in the Forced Swimming Test in Mice." Neuroscience Letters, vol. 363, no. 1, 2004, pp. 25-8.
Berrocoso E, Rojas-Corrales MO, Micó JA. Non-selective opioid receptor antagonism of the antidepressant-like effect of venlafaxine in the forced swimming test in mice. Neurosci Lett. 2004;363(1):25-8.
Berrocoso, E., Rojas-Corrales, M. O., & Micó, J. A. (2004). Non-selective opioid receptor antagonism of the antidepressant-like effect of venlafaxine in the forced swimming test in mice. Neuroscience Letters, 363(1), 25-8.
Berrocoso E, Rojas-Corrales MO, Micó JA. Non-selective Opioid Receptor Antagonism of the Antidepressant-like Effect of Venlafaxine in the Forced Swimming Test in Mice. Neurosci Lett. 2004 Jun 3;363(1):25-8. PubMed PMID: 15157989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-selective opioid receptor antagonism of the antidepressant-like effect of venlafaxine in the forced swimming test in mice. AU - Berrocoso,Esther, AU - Rojas-Corrales,María Olga, AU - Micó,Juan Antonio, PY - 2003/08/08/received PY - 2004/03/06/revised PY - 2004/03/06/accepted PY - 2004/5/26/pubmed PY - 2004/7/9/medline PY - 2004/5/26/entrez SP - 25 EP - 8 JF - Neuroscience letters JO - Neurosci Lett VL - 363 IS - 1 N2 - The opioid system has been implicated in mood disorders as well as in the mechanism of action of antidepressants. Since the opioid component in venlafaxine (VLX) is still a matter of discussion, we investigated the role of opioid receptors in the antidepressant-like effect of VLX in the forced swimming test in mice. The non-selective opiate antagonist naloxone at high dose (2 mg/kg, s.c.) antagonized the effect of VLX. In contrast, beta-funaltrexamine (40 mg/kg, s.c.), which preferentially blocks mu(1)/mu(2) opioid receptors, naloxonazine (35 mg/kg, s.c.), a selective mu(1) opioid antagonist, naltrindole (10 mg/kg, s.c.), a selective delta opioid antagonist, and Nor-binaltorphimine (10 mg/kg, s.c.), which selectively blocks kappa-opioid receptors, were all ineffective. Thus, although apparently mediated by the opioid system, the behavioural effect of VLX does not involve specific opioid receptors. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15157989/Non_selective_opioid_receptor_antagonism_of_the_antidepressant_like_effect_of_venlafaxine_in_the_forced_swimming_test_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394004003532 DB - PRIME DP - Unbound Medicine ER -