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Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum.
Life Sci 2004; 75(5):633-8LS

Abstract

Preclinical and clinical studies suggest that cannabidiol (CBD), a major component of Cannabis sativa, could produce antipsychotic effects without causing extra-pyramidal side-effects. In the present paper we employed the detection of Fos protein to investigate neuronal activation in the dorsal striatum and nucleus accumbens of male Wistar rats after systemic administration of CBD (120 mg/kg), haloperidol (1 mg/kg) or clozapine (20 mg/kg). Only haloperidol was able to increase the number of Fos immunoreactive neurons (FIr) in the dorsal striatum (vehicle: 0.07 +/- 0.07/0.1 mm(2), haloperidol: 28.3 +/- 8.9/0.1 mm(2), p < 0.01). In contrast, both haloperidol and CBD significantly increased FIr in the nucleus accumbens (Vehicle: 0 +/- 0/0.1 mm(2), haloperidol: 7.2 +/- 2.7/0.1 mm(2), CBD: 4.0 +/- 1.9/0.1 mm(2), p < 0.05). Clozapine also produced a barely significant increase in FIr (3.0 +/- 1.7/0.1 mm(2), p = 0.062). These results show that CBD is able to induce FIr in a limbic- but not in a motor-related area.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Campus USP, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14049-900, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15158372

Citation

Guimarães, Viviane M C., et al. "Cannabidiol Increases Fos Expression in the Nucleus Accumbens but Not in the Dorsal Striatum." Life Sciences, vol. 75, no. 5, 2004, pp. 633-8.
Guimarães VM, Zuardi AW, Del Bel EA, et al. Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. Life Sci. 2004;75(5):633-8.
Guimarães, V. M., Zuardi, A. W., Del Bel, E. A., & Guimarães, F. S. (2004). Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. Life Sciences, 75(5), pp. 633-8.
Guimarães VM, et al. Cannabidiol Increases Fos Expression in the Nucleus Accumbens but Not in the Dorsal Striatum. Life Sci. 2004 Jun 18;75(5):633-8. PubMed PMID: 15158372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. AU - Guimarães,Viviane M C, AU - Zuardi,Antonio W, AU - Del Bel,Elaine Aparecida, AU - Guimarães,Francisco S, PY - 2003/10/16/received PY - 2004/01/22/accepted PY - 2004/5/26/pubmed PY - 2004/7/21/medline PY - 2004/5/26/entrez SP - 633 EP - 8 JF - Life sciences JO - Life Sci. VL - 75 IS - 5 N2 - Preclinical and clinical studies suggest that cannabidiol (CBD), a major component of Cannabis sativa, could produce antipsychotic effects without causing extra-pyramidal side-effects. In the present paper we employed the detection of Fos protein to investigate neuronal activation in the dorsal striatum and nucleus accumbens of male Wistar rats after systemic administration of CBD (120 mg/kg), haloperidol (1 mg/kg) or clozapine (20 mg/kg). Only haloperidol was able to increase the number of Fos immunoreactive neurons (FIr) in the dorsal striatum (vehicle: 0.07 +/- 0.07/0.1 mm(2), haloperidol: 28.3 +/- 8.9/0.1 mm(2), p < 0.01). In contrast, both haloperidol and CBD significantly increased FIr in the nucleus accumbens (Vehicle: 0 +/- 0/0.1 mm(2), haloperidol: 7.2 +/- 2.7/0.1 mm(2), CBD: 4.0 +/- 1.9/0.1 mm(2), p < 0.05). Clozapine also produced a barely significant increase in FIr (3.0 +/- 1.7/0.1 mm(2), p = 0.062). These results show that CBD is able to induce FIr in a limbic- but not in a motor-related area. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/15158372/Cannabidiol_increases_Fos_expression_in_the_nucleus_accumbens_but_not_in_the_dorsal_striatum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024320504002917 DB - PRIME DP - Unbound Medicine ER -