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Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum.

Abstract

Preclinical and clinical studies suggest that cannabidiol (CBD), a major component of Cannabis sativa, could produce antipsychotic effects without causing extra-pyramidal side-effects. In the present paper we employed the detection of Fos protein to investigate neuronal activation in the dorsal striatum and nucleus accumbens of male Wistar rats after systemic administration of CBD (120 mg/kg), haloperidol (1 mg/kg) or clozapine (20 mg/kg). Only haloperidol was able to increase the number of Fos immunoreactive neurons (FIr) in the dorsal striatum (vehicle: 0.07 +/- 0.07/0.1 mm(2), haloperidol: 28.3 +/- 8.9/0.1 mm(2), p < 0.01). In contrast, both haloperidol and CBD significantly increased FIr in the nucleus accumbens (Vehicle: 0 +/- 0/0.1 mm(2), haloperidol: 7.2 +/- 2.7/0.1 mm(2), CBD: 4.0 +/- 1.9/0.1 mm(2), p < 0.05). Clozapine also produced a barely significant increase in FIr (3.0 +/- 1.7/0.1 mm(2), p = 0.062). These results show that CBD is able to induce FIr in a limbic- but not in a motor-related area.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacology, School of Medicine, Campus USP, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14049-900, Brazil.

    , ,

    Source

    Life sciences 75:5 2004 Jun 18 pg 633-8

    MeSH

    Animals
    Cannabidiol
    Clozapine
    Haloperidol
    Injections, Intraperitoneal
    Male
    Neostriatum
    Nucleus Accumbens
    Proto-Oncogene Proteins c-fos
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15158372

    Citation

    Guimarães, Viviane M C., et al. "Cannabidiol Increases Fos Expression in the Nucleus Accumbens but Not in the Dorsal Striatum." Life Sciences, vol. 75, no. 5, 2004, pp. 633-8.
    Guimarães VM, Zuardi AW, Del Bel EA, et al. Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. Life Sci. 2004;75(5):633-8.
    Guimarães, V. M., Zuardi, A. W., Del Bel, E. A., & Guimarães, F. S. (2004). Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. Life Sciences, 75(5), pp. 633-8.
    Guimarães VM, et al. Cannabidiol Increases Fos Expression in the Nucleus Accumbens but Not in the Dorsal Striatum. Life Sci. 2004 Jun 18;75(5):633-8. PubMed PMID: 15158372.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. AU - Guimarães,Viviane M C, AU - Zuardi,Antonio W, AU - Del Bel,Elaine Aparecida, AU - Guimarães,Francisco S, PY - 2003/10/16/received PY - 2004/01/22/accepted PY - 2004/5/26/pubmed PY - 2004/7/21/medline PY - 2004/5/26/entrez SP - 633 EP - 8 JF - Life sciences JO - Life Sci. VL - 75 IS - 5 N2 - Preclinical and clinical studies suggest that cannabidiol (CBD), a major component of Cannabis sativa, could produce antipsychotic effects without causing extra-pyramidal side-effects. In the present paper we employed the detection of Fos protein to investigate neuronal activation in the dorsal striatum and nucleus accumbens of male Wistar rats after systemic administration of CBD (120 mg/kg), haloperidol (1 mg/kg) or clozapine (20 mg/kg). Only haloperidol was able to increase the number of Fos immunoreactive neurons (FIr) in the dorsal striatum (vehicle: 0.07 +/- 0.07/0.1 mm(2), haloperidol: 28.3 +/- 8.9/0.1 mm(2), p < 0.01). In contrast, both haloperidol and CBD significantly increased FIr in the nucleus accumbens (Vehicle: 0 +/- 0/0.1 mm(2), haloperidol: 7.2 +/- 2.7/0.1 mm(2), CBD: 4.0 +/- 1.9/0.1 mm(2), p < 0.05). Clozapine also produced a barely significant increase in FIr (3.0 +/- 1.7/0.1 mm(2), p = 0.062). These results show that CBD is able to induce FIr in a limbic- but not in a motor-related area. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/15158372/Cannabidiol_increases_Fos_expression_in_the_nucleus_accumbens_but_not_in_the_dorsal_striatum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024320504002917 DB - PRIME DP - Unbound Medicine ER -