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Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC.
Immunol Lett. 2004 May 15; 93(2-3):143-9.IL

Abstract

N-Chlorotaurine (NCT) plays an important role in the human defense system as a main component of long-lived oxidants, and shows bactericidal, fungicidal, and virucidal activity. Besides this role, NCT seems to act regulatory on immunocompetent cells by altering cytokine production. NCT inhibited nitric oxide, TNF-alpha, and prostaglandin E(2) (PGE(2)) production in activated rodent macrophages, and suppressed superoxide anion, IL-6, and IL-8 formation in human polymorphonuclear leukocytes. In this study, the influence of NCT on the production of neopterin and the activation of the enzyme indoleamine-2,3 dioxygenase (IDO) was investigated in human peripheral blood mononuclear cells (PBMC). Both events are well established to be triggered by IFN-gamma and therefore related to Th1-type immune activation. Mitogen-induced neopterin production as well as tryptophan degradation were drastically reduced upon addition of NCT. Results fit in the concept of a reduction of pro-inflammatory cytokines by this compound. In contrast to earlier results, where NCT was suggested to act primarily down-regulatory on Th2 cells, we propose also a strong suppressive effect of NCT on Th1-type immunity.

Authors+Show Affiliations

Institute of Medical Chemistry and Biochemistry, Medical University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15158610

Citation

Wirleitner, Barbara, et al. "Down-regulatory Effect of N-chlorotaurine On Tryptophan Degradation and Neopterin Production in Human PBMC." Immunology Letters, vol. 93, no. 2-3, 2004, pp. 143-9.
Wirleitner B, Neurauter G, Nagl M, et al. Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC. Immunol Lett. 2004;93(2-3):143-9.
Wirleitner, B., Neurauter, G., Nagl, M., & Fuchs, D. (2004). Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC. Immunology Letters, 93(2-3), 143-9.
Wirleitner B, et al. Down-regulatory Effect of N-chlorotaurine On Tryptophan Degradation and Neopterin Production in Human PBMC. Immunol Lett. 2004 May 15;93(2-3):143-9. PubMed PMID: 15158610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC. AU - Wirleitner,Barbara, AU - Neurauter,Gabriele, AU - Nagl,Markus, AU - Fuchs,Dietmar, PY - 2004/01/08/received PY - 2004/03/09/revised PY - 2004/03/09/accepted PY - 2004/5/26/pubmed PY - 2005/3/22/medline PY - 2004/5/26/entrez SP - 143 EP - 9 JF - Immunology letters JO - Immunol. Lett. VL - 93 IS - 2-3 N2 - N-Chlorotaurine (NCT) plays an important role in the human defense system as a main component of long-lived oxidants, and shows bactericidal, fungicidal, and virucidal activity. Besides this role, NCT seems to act regulatory on immunocompetent cells by altering cytokine production. NCT inhibited nitric oxide, TNF-alpha, and prostaglandin E(2) (PGE(2)) production in activated rodent macrophages, and suppressed superoxide anion, IL-6, and IL-8 formation in human polymorphonuclear leukocytes. In this study, the influence of NCT on the production of neopterin and the activation of the enzyme indoleamine-2,3 dioxygenase (IDO) was investigated in human peripheral blood mononuclear cells (PBMC). Both events are well established to be triggered by IFN-gamma and therefore related to Th1-type immune activation. Mitogen-induced neopterin production as well as tryptophan degradation were drastically reduced upon addition of NCT. Results fit in the concept of a reduction of pro-inflammatory cytokines by this compound. In contrast to earlier results, where NCT was suggested to act primarily down-regulatory on Th2 cells, we propose also a strong suppressive effect of NCT on Th1-type immunity. SN - 0165-2478 UR - https://www.unboundmedicine.com/medline/citation/15158610/Down_regulatory_effect_of_N_chlorotaurine_on_tryptophan_degradation_and_neopterin_production_in_human_PBMC_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165247804000641 DB - PRIME DP - Unbound Medicine ER -