TY - JOUR T1 - Bioavailability of carbamazepine:beta-cyclodextrin complex in beagle dogs from hydroxypropylmethylcellulose matrix tablets. AU - Koester,Letícia S, AU - Bertuol,Juliana B, AU - Groch,Kátia R, AU - Xavier,Clarissa R, AU - Moellerke,Roseli, AU - Mayorga,Paulo, AU - Dalla Costa,Teresa, AU - Bassani,Valquiria L, PY - 2003/09/03/received PY - 2004/02/19/revised PY - 2004/03/02/accepted PY - 2004/5/26/pubmed PY - 2005/1/19/medline PY - 2004/5/26/entrez SP - 201 EP - 7 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 22 IS - 2-3 N2 - The bioavailability of a carbamazepine:beta-cyclodextrin (CBZ:betaCD) complex from hydroxypropylmethylcellulose (HPMC) matrix tablets was evaluated in beagle dogs. A solubility study demonstrated the improvement of CBZ aqueous solubility by adding increasing amounts of betaCD. The 1:1 CBZ:betaCD molar ratio was chosen to produce the complex, which was obtained by spray-drying. Matrix tablets were prepared by direct compressing either a CBZ:betaCD complex or a physical mixture of both substances with HPMC. Both matrix formulations displayed a controlled-release profile when compared to the reference formulation (Tegretol CR 200). CBZ presented a significantly higher bioavailability from matrix tablets containing the CBZ:betaCD complex than that obtained from Tegretol CR 200). Although a high inter-subject variability was observed, the results pointed to the feasibility of using betaCD in order to modulate CBZ release and absorption, as well as to reduce the drug dosage maintaining the same plasma levels. SN - 0928-0987 UR - https://www.unboundmedicine.com/medline/citation/15158905/Bioavailability_of_carbamazepine:beta_cyclodextrin_complex_in_beagle_dogs_from_hydroxypropylmethylcellulose_matrix_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928098704000752 DB - PRIME DP - Unbound Medicine ER -