Citation
Koester, Letícia S., et al. "Bioavailability of Carbamazepine:beta-cyclodextrin Complex in Beagle Dogs From Hydroxypropylmethylcellulose Matrix Tablets." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 22, no. 2-3, 2004, pp. 201-7.
Koester LS, Bertuol JB, Groch KR, et al. Bioavailability of carbamazepine:beta-cyclodextrin complex in beagle dogs from hydroxypropylmethylcellulose matrix tablets. Eur J Pharm Sci. 2004;22(2-3):201-7.
Koester, L. S., Bertuol, J. B., Groch, K. R., Xavier, C. R., Moellerke, R., Mayorga, P., Dalla Costa, T., & Bassani, V. L. (2004). Bioavailability of carbamazepine:beta-cyclodextrin complex in beagle dogs from hydroxypropylmethylcellulose matrix tablets. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 22(2-3), 201-7.
Koester LS, et al. Bioavailability of Carbamazepine:beta-cyclodextrin Complex in Beagle Dogs From Hydroxypropylmethylcellulose Matrix Tablets. Eur J Pharm Sci. 2004;22(2-3):201-7. PubMed PMID: 15158905.
TY - JOUR
T1 - Bioavailability of carbamazepine:beta-cyclodextrin complex in beagle dogs from hydroxypropylmethylcellulose matrix tablets.
AU - Koester,Letícia S,
AU - Bertuol,Juliana B,
AU - Groch,Kátia R,
AU - Xavier,Clarissa R,
AU - Moellerke,Roseli,
AU - Mayorga,Paulo,
AU - Dalla Costa,Teresa,
AU - Bassani,Valquiria L,
PY - 2003/09/03/received
PY - 2004/02/19/revised
PY - 2004/03/02/accepted
PY - 2004/5/26/pubmed
PY - 2005/1/19/medline
PY - 2004/5/26/entrez
SP - 201
EP - 7
JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
JO - Eur J Pharm Sci
VL - 22
IS - 2-3
N2 - The bioavailability of a carbamazepine:beta-cyclodextrin (CBZ:betaCD) complex from hydroxypropylmethylcellulose (HPMC) matrix tablets was evaluated in beagle dogs. A solubility study demonstrated the improvement of CBZ aqueous solubility by adding increasing amounts of betaCD. The 1:1 CBZ:betaCD molar ratio was chosen to produce the complex, which was obtained by spray-drying. Matrix tablets were prepared by direct compressing either a CBZ:betaCD complex or a physical mixture of both substances with HPMC. Both matrix formulations displayed a controlled-release profile when compared to the reference formulation (Tegretol CR 200). CBZ presented a significantly higher bioavailability from matrix tablets containing the CBZ:betaCD complex than that obtained from Tegretol CR 200). Although a high inter-subject variability was observed, the results pointed to the feasibility of using betaCD in order to modulate CBZ release and absorption, as well as to reduce the drug dosage maintaining the same plasma levels.
SN - 0928-0987
UR - https://www.unboundmedicine.com/medline/citation/15158905/Bioavailability_of_carbamazepine:beta_cyclodextrin_complex_in_beagle_dogs_from_hydroxypropylmethylcellulose_matrix_tablets_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928098704000752
DB - PRIME
DP - Unbound Medicine
ER -