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Cytotoxicity and antibacterial activity of extractives from Wedelia calendulacea.
Fitoterapia. 2004 Jun; 75(3-4):355-9.F

Abstract

The cytotoxicity and antibacterial activity of petroleum ether, chloroform and methanol extracts of Wedelia calendulacea were assayed by brine shrimp lethality bioassay and standardized disk diffusion method against 19 bacterial strains. Three diterpenes isolated from the plant were also evaluated for in vitro antibacterial activities. The LC50 for the crude extracts against the brine shrimp nauplii were found to be 4.59 microg/ml, 7.99 microg/ml and 14.88 microg/ml, respectively, whereas the positive control, vincristine sulfate showed an LC50 of 0.58 microg/ml. Among the crude extracts and pure compounds tested, (-)-kaur-16-en-19-oic acid isolated from the chloroform extract showed the highest inhibitory activity against most of the bacterial strains with mean zone of inhibition of 10-21 mm at 200 microg/disc.

Authors+Show Affiliations

Mottakin AK
Department of Applied Chemistry and Chemical Technology, University of Dhaka, Dhaka 1000, Bangladesh.
Chowdhury R
No affiliation info available
Haider MS
No affiliation info available
Rahman KM
No affiliation info available
Hasan CM
No affiliation info available
Rashid MA
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsAntineoplastic Agents, PhytogenicArtemiaGram-Negative BacteriaGram-Positive BacteriaHumansLethal Dose 50Microbial Sensitivity TestsPhytotherapyPlant ExtractsWedelia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15158994

Citation

Mottakin, A K M., et al. "Cytotoxicity and Antibacterial Activity of Extractives From Wedelia Calendulacea." Fitoterapia, vol. 75, no. 3-4, 2004, pp. 355-9.
Mottakin AK, Chowdhury R, Haider MS, et al. Cytotoxicity and antibacterial activity of extractives from Wedelia calendulacea. Fitoterapia. 2004;75(3-4):355-9.
Mottakin, A. K., Chowdhury, R., Haider, M. S., Rahman, K. M., Hasan, C. M., & Rashid, M. A. (2004). Cytotoxicity and antibacterial activity of extractives from Wedelia calendulacea. Fitoterapia, 75(3-4), 355-9.
Mottakin AK, et al. Cytotoxicity and Antibacterial Activity of Extractives From Wedelia Calendulacea. Fitoterapia. 2004;75(3-4):355-9. PubMed PMID: 15158994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxicity and antibacterial activity of extractives from Wedelia calendulacea. AU - Mottakin,A K M, AU - Chowdhury,R, AU - Haider,M S, AU - Rahman,K M, AU - Hasan,C M, AU - Rashid,M A, PY - 2003/01/22/received PY - 2003/12/11/accepted PY - 2004/5/26/pubmed PY - 2004/7/21/medline PY - 2004/5/26/entrez SP - 355 EP - 9 JF - Fitoterapia JO - Fitoterapia VL - 75 IS - 3-4 N2 - The cytotoxicity and antibacterial activity of petroleum ether, chloroform and methanol extracts of Wedelia calendulacea were assayed by brine shrimp lethality bioassay and standardized disk diffusion method against 19 bacterial strains. Three diterpenes isolated from the plant were also evaluated for in vitro antibacterial activities. The LC50 for the crude extracts against the brine shrimp nauplii were found to be 4.59 microg/ml, 7.99 microg/ml and 14.88 microg/ml, respectively, whereas the positive control, vincristine sulfate showed an LC50 of 0.58 microg/ml. Among the crude extracts and pure compounds tested, (-)-kaur-16-en-19-oic acid isolated from the chloroform extract showed the highest inhibitory activity against most of the bacterial strains with mean zone of inhibition of 10-21 mm at 200 microg/disc. SN - 0367-326X UR - https://www.unboundmedicine.com/medline/citation/15158994/Cytotoxicity_and_antibacterial_activity_of_extractives_from_Wedelia_calendulacea_ DB - PRIME DP - Unbound Medicine ER -