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Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone.
Am J Clin Nutr. 2004 Jun; 79(6):1020-8.AJ

Abstract

BACKGROUND

Wheat bran (WB) increases fecal bulk and hastens colonic transit, whereas resistant starch (RS) has effects on colonic fermentation, including increasing concentrations of butyrate.

OBJECTIVE

We hypothesized that a diet combining WB with RS would produce more favorable changes in fecal variables (eg, fecal bulk, rapid transit time, lower pH, and higher butyrate) than would WB alone.

DESIGN

This was a randomized crossover block-design study for which 20 volunteers with a family history of colorectal cancer were recruited. The study included 3 diets: control, WB (12 g fiber/d), and WBRS (12 g WB fiber/d plus 22 g RS/d), each continued for 3 wk. In each diet, the major source of protein was lean red meat. During 5 consecutive days (days 15-19) of each dietary period, the subjects collected their total fecal output for analysis.

RESULTS

The WB diet resulted in greater fecal output (by 23% and 21% for wet and dry weights, respectively) and a lesser transit time (-11 h) than did the control diet but did not have major effects on fermentation variables. Compared with the control diet, the WBRS diet resulted in greater fecal output (by 56%) and a shorter transit time (-10 h), lower fecal pH (-0.15 units), higher fecal concentration (by 14%) and daily excretion (by 101%) of acetate, higher fecal concentration (by 79%) and daily excretion (by 162%) of butyrate, a higher fecal ratio of butyrate to total short-chain fatty acids (by 45%), and lower concentrations of total phenols (-34%) and ammonia (-27%).

CONCLUSIONS

Combining WB with RS had more benefits than did WB alone. This finding may have important implications for the dietary modulation of luminal contents, especially in the distal colon (the most common site of tumor formation).

Authors+Show Affiliations

Department of Gastroenterology, Monash University, Box Hill Hospital, Victoria, Australia. jane.muir@med.monash.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15159232

Citation

Muir, Jane G., et al. "Combining Wheat Bran With Resistant Starch Has More Beneficial Effects On Fecal Indexes Than Does Wheat Bran Alone." The American Journal of Clinical Nutrition, vol. 79, no. 6, 2004, pp. 1020-8.
Muir JG, Yeow EG, Keogh J, et al. Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone. Am J Clin Nutr. 2004;79(6):1020-8.
Muir, J. G., Yeow, E. G., Keogh, J., Pizzey, C., Bird, A. R., Sharpe, K., O'Dea, K., & Macrae, F. A. (2004). Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone. The American Journal of Clinical Nutrition, 79(6), 1020-8.
Muir JG, et al. Combining Wheat Bran With Resistant Starch Has More Beneficial Effects On Fecal Indexes Than Does Wheat Bran Alone. Am J Clin Nutr. 2004;79(6):1020-8. PubMed PMID: 15159232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone. AU - Muir,Jane G, AU - Yeow,Elaine G W, AU - Keogh,Jennifer, AU - Pizzey,Catherine, AU - Bird,Anthony R, AU - Sharpe,Ken, AU - O'Dea,Kerin, AU - Macrae,Finlay A, PY - 2004/5/26/pubmed PY - 2004/6/16/medline PY - 2004/5/26/entrez SP - 1020 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 79 IS - 6 N2 - BACKGROUND: Wheat bran (WB) increases fecal bulk and hastens colonic transit, whereas resistant starch (RS) has effects on colonic fermentation, including increasing concentrations of butyrate. OBJECTIVE: We hypothesized that a diet combining WB with RS would produce more favorable changes in fecal variables (eg, fecal bulk, rapid transit time, lower pH, and higher butyrate) than would WB alone. DESIGN: This was a randomized crossover block-design study for which 20 volunteers with a family history of colorectal cancer were recruited. The study included 3 diets: control, WB (12 g fiber/d), and WBRS (12 g WB fiber/d plus 22 g RS/d), each continued for 3 wk. In each diet, the major source of protein was lean red meat. During 5 consecutive days (days 15-19) of each dietary period, the subjects collected their total fecal output for analysis. RESULTS: The WB diet resulted in greater fecal output (by 23% and 21% for wet and dry weights, respectively) and a lesser transit time (-11 h) than did the control diet but did not have major effects on fermentation variables. Compared with the control diet, the WBRS diet resulted in greater fecal output (by 56%) and a shorter transit time (-10 h), lower fecal pH (-0.15 units), higher fecal concentration (by 14%) and daily excretion (by 101%) of acetate, higher fecal concentration (by 79%) and daily excretion (by 162%) of butyrate, a higher fecal ratio of butyrate to total short-chain fatty acids (by 45%), and lower concentrations of total phenols (-34%) and ammonia (-27%). CONCLUSIONS: Combining WB with RS had more benefits than did WB alone. This finding may have important implications for the dietary modulation of luminal contents, especially in the distal colon (the most common site of tumor formation). SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15159232/Combining_wheat_bran_with_resistant_starch_has_more_beneficial_effects_on_fecal_indexes_than_does_wheat_bran_alone_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/79.6.1020 DB - PRIME DP - Unbound Medicine ER -