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Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men.
Arch Intern Med 2004; 164(10):1092-7AI

Abstract

BACKGROUND

The metabolic syndrome is a prevalent condition that carries with it an increased risk of type 2 diabetes mellitus, cardiovascular disease (CVD), and mortality.

OBJECTIVE

To determine the relationship between cardiorespiratory fitness (CRF) and mortality in healthy men and in those with the metabolic syndrome.

METHODS

The sample included 19 223 men, aged 20 to 83 years, who received a clinical evaluation between 1979 and 1995 with mortality follow-up through December 31, 1996. There were 15 466 healthy men (80.5%) and 3757 men with the metabolic syndrome (19.5%).

RESULTS

A total of 480 deaths (161 due to CVD) occurred during 196 298 man-years of follow-up. After adjustment for age, year of examination, smoking status, alcohol consumption, and parental CVD, the relative risks (RRs) (95% confidence interval) of all-cause and CVD mortality were 1.29 (1.05-1.57) and 1.89 (1.36-2.60), respectively, for men with the metabolic syndrome compared with healthy men. After the inclusion of CRF, the associations were not significant. The RRs comparing unfit with fit men for all-cause mortality were 2.18 (1.66-2.87) in healthy men and 2.01 (1.38-2.93) in men with the metabolic syndrome, whereas the RRs for CVD mortality for unfit vs fit men were 3.21 (2.03-5.07) in healthy men and 2.25 (1.27-3.97) in men with the metabolic syndrome. A significant dose-response relationship between CRF and mortality was also observed in men with the metabolic syndrome.

CONCLUSION

In this sample, CRF provided a strong protective effect against all-cause and CVD mortality in healthy men and men with the metabolic syndrome.

Authors+Show Affiliations

School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6. katzmarz@post.queensu.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15159266

Citation

Katzmarzyk, Peter T., et al. "Cardiorespiratory Fitness Attenuates the Effects of the Metabolic Syndrome On All-cause and Cardiovascular Disease Mortality in Men." Archives of Internal Medicine, vol. 164, no. 10, 2004, pp. 1092-7.
Katzmarzyk PT, Church TS, Blair SN. Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men. Arch Intern Med. 2004;164(10):1092-7.
Katzmarzyk, P. T., Church, T. S., & Blair, S. N. (2004). Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men. Archives of Internal Medicine, 164(10), pp. 1092-7.
Katzmarzyk PT, Church TS, Blair SN. Cardiorespiratory Fitness Attenuates the Effects of the Metabolic Syndrome On All-cause and Cardiovascular Disease Mortality in Men. Arch Intern Med. 2004 May 24;164(10):1092-7. PubMed PMID: 15159266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men. AU - Katzmarzyk,Peter T, AU - Church,Timothy S, AU - Blair,Steven N, PY - 2004/5/26/pubmed PY - 2004/6/16/medline PY - 2004/5/26/entrez SP - 1092 EP - 7 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 164 IS - 10 N2 - BACKGROUND: The metabolic syndrome is a prevalent condition that carries with it an increased risk of type 2 diabetes mellitus, cardiovascular disease (CVD), and mortality. OBJECTIVE: To determine the relationship between cardiorespiratory fitness (CRF) and mortality in healthy men and in those with the metabolic syndrome. METHODS: The sample included 19 223 men, aged 20 to 83 years, who received a clinical evaluation between 1979 and 1995 with mortality follow-up through December 31, 1996. There were 15 466 healthy men (80.5%) and 3757 men with the metabolic syndrome (19.5%). RESULTS: A total of 480 deaths (161 due to CVD) occurred during 196 298 man-years of follow-up. After adjustment for age, year of examination, smoking status, alcohol consumption, and parental CVD, the relative risks (RRs) (95% confidence interval) of all-cause and CVD mortality were 1.29 (1.05-1.57) and 1.89 (1.36-2.60), respectively, for men with the metabolic syndrome compared with healthy men. After the inclusion of CRF, the associations were not significant. The RRs comparing unfit with fit men for all-cause mortality were 2.18 (1.66-2.87) in healthy men and 2.01 (1.38-2.93) in men with the metabolic syndrome, whereas the RRs for CVD mortality for unfit vs fit men were 3.21 (2.03-5.07) in healthy men and 2.25 (1.27-3.97) in men with the metabolic syndrome. A significant dose-response relationship between CRF and mortality was also observed in men with the metabolic syndrome. CONCLUSION: In this sample, CRF provided a strong protective effect against all-cause and CVD mortality in healthy men and men with the metabolic syndrome. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15159266/Cardiorespiratory_fitness_attenuates_the_effects_of_the_metabolic_syndrome_on_all_cause_and_cardiovascular_disease_mortality_in_men_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.164.10.1092 DB - PRIME DP - Unbound Medicine ER -