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Increased plasma levels of insulin-like growth factor 2 and insulin-like growth factor binding protein 3 are associated with endometrial cancer risk.
Cancer Epidemiol Biomarkers Prev. 2004 May; 13(5):748-52.CE

Abstract

Circulating insulin-like growth factors (IGFs) and their binding proteins have been associated with increased risk of breast, prostate, colon, and lung cancer. To examine the association of IGFs and endometrial cancer risk, we measured the plasma levels of IGF-1, IGF-2, and IGF binding protein 3 (IGFBP-3) by ELISA in 80 women with endometrial cancer and 80 age-matched control subjects with no history of cancer. Mean plasma levels of IGF-2 were significantly higher in women with cancer versus controls (670 ng/ml versus 380 ng/ml, P < 0.001). In contrast, significantly lower mean plasma levels of IGF-1 (155 mg/ml versus 185 ng/ml, P < 0.01) and IGFBP-3 (1703 ng/ml versus 2170 ng/ml, P < 0.001) were observed among cases compared to the control group. Women in the highest quartile of IGF-2 were found to have 9.67 (95% confidence interval 3.29-28.43) times the risk of endometrial cancer than women in the lowest quartiles. Women in the highest quartile of IGFBP-3 were associated with a significantly decreased risk for developing endometrial cancer (odds ratio = 0.23, 95% confidence interval 0.09-0.60). These data suggest that increased plasma levels of IGF-2 and decreased levels of IGFBP-3 are associated with an increased risk of endometrial cancer. Further validation of these results is needed to determine the potential usefulness of risk assessment.

Authors+Show Affiliations

The Department of Gynecological Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030,USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15159305

Citation

Oh, Jonathan C., et al. "Increased Plasma Levels of Insulin-like Growth Factor 2 and Insulin-like Growth Factor Binding Protein 3 Are Associated With Endometrial Cancer Risk." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 5, 2004, pp. 748-52.
Oh JC, Wu W, Tortolero-Luna G, et al. Increased plasma levels of insulin-like growth factor 2 and insulin-like growth factor binding protein 3 are associated with endometrial cancer risk. Cancer Epidemiol Biomarkers Prev. 2004;13(5):748-52.
Oh, J. C., Wu, W., Tortolero-Luna, G., Broaddus, R., Gershenson, D. M., Burke, T. W., Schmandt, R., & Lu, K. H. (2004). Increased plasma levels of insulin-like growth factor 2 and insulin-like growth factor binding protein 3 are associated with endometrial cancer risk. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(5), 748-52.
Oh JC, et al. Increased Plasma Levels of Insulin-like Growth Factor 2 and Insulin-like Growth Factor Binding Protein 3 Are Associated With Endometrial Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2004;13(5):748-52. PubMed PMID: 15159305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased plasma levels of insulin-like growth factor 2 and insulin-like growth factor binding protein 3 are associated with endometrial cancer risk. AU - Oh,Jonathan C, AU - Wu,Weiguo, AU - Tortolero-Luna,Guillermo, AU - Broaddus,Russell, AU - Gershenson,David M, AU - Burke,Thomas W, AU - Schmandt,Rosemarie, AU - Lu,Karen H, PY - 2004/5/26/pubmed PY - 2004/9/8/medline PY - 2004/5/26/entrez SP - 748 EP - 52 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 5 N2 - Circulating insulin-like growth factors (IGFs) and their binding proteins have been associated with increased risk of breast, prostate, colon, and lung cancer. To examine the association of IGFs and endometrial cancer risk, we measured the plasma levels of IGF-1, IGF-2, and IGF binding protein 3 (IGFBP-3) by ELISA in 80 women with endometrial cancer and 80 age-matched control subjects with no history of cancer. Mean plasma levels of IGF-2 were significantly higher in women with cancer versus controls (670 ng/ml versus 380 ng/ml, P < 0.001). In contrast, significantly lower mean plasma levels of IGF-1 (155 mg/ml versus 185 ng/ml, P < 0.01) and IGFBP-3 (1703 ng/ml versus 2170 ng/ml, P < 0.001) were observed among cases compared to the control group. Women in the highest quartile of IGF-2 were found to have 9.67 (95% confidence interval 3.29-28.43) times the risk of endometrial cancer than women in the lowest quartiles. Women in the highest quartile of IGFBP-3 were associated with a significantly decreased risk for developing endometrial cancer (odds ratio = 0.23, 95% confidence interval 0.09-0.60). These data suggest that increased plasma levels of IGF-2 and decreased levels of IGFBP-3 are associated with an increased risk of endometrial cancer. Further validation of these results is needed to determine the potential usefulness of risk assessment. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15159305/Increased_plasma_levels_of_insulin_like_growth_factor_2_and_insulin_like_growth_factor_binding_protein_3_are_associated_with_endometrial_cancer_risk_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=15159305 DB - PRIME DP - Unbound Medicine ER -