Tags

Type your tag names separated by a space and hit enter

Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables.

Abstract

BACKGROUND

Due to the random and systematic measurement errors associated with current dietary assessment instruments, there is a need to develop more objective methods of measuring the intake of foods of importance to human health.

OBJECTIVE

The purpose of this study was to test whether urinary excretion of flavonoids could be used to identify subjects who are meeting Norwegian recommendations for fruit and vegetable intake (5 servings per day) from individuals who are consuming the national average amount of fruits and vegetables (2 servings per day).

DESIGN

Twenty-four-hour urine samples were collected in a strict crossover controlled feeding study. Forty healthy subjects (19-34 years) were included in the study. After a 1-week run-in period, one group was given a controlled diet that included 2 servings (300 g) of fruits and vegetables daily for 14 days, while the other group was given a diet containing 5 servings (750 g) per day. Following a 2-week washout and a 1 week run-in period, the regimens were switched between the groups.

RESULTS

An increased intake of mixed fruits and vegetables from 2 to 5 servings per day significantly enhanced urinary excretion of eriodictyol, naringenin, hesperetin, quercetin, kaempferol, isorhamnetin, and tamarixetin. The citrus flavonoids naringenin and hesperetin showed a steep dose-response relationship to dietary intake of fruits and vegetables, whereas the association to eriodictyol, quercetin, kaempferol, isorhamnetin, and tamarixetin was more moderate.

CONCLUSION

The present study indicates that urinary excretion of dietary flavonoids may be used to assess changes of mixed fruit and vegetable intake corresponding to an increase from the present national intake in Norway to the recommended amount of 5 servings of fruits and vegetables daily.

Authors+Show Affiliations

Institute for Nutrition Research, School of Medicine, University of Oslo, P. O. Box 1046, 0316 Oslo, Norway. asgeir.brevik@basalmed.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15159318

Citation

Brevik, Asgeir, et al. "Urinary Excretion of Flavonoids Reflects Even Small Changes in the Dietary Intake of Fruits and Vegetables." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 5, 2004, pp. 843-9.
Brevik A, Rasmussen SE, Drevon CA, et al. Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables. Cancer Epidemiol Biomarkers Prev. 2004;13(5):843-9.
Brevik, A., Rasmussen, S. E., Drevon, C. A., & Andersen, L. F. (2004). Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(5), pp. 843-9.
Brevik A, et al. Urinary Excretion of Flavonoids Reflects Even Small Changes in the Dietary Intake of Fruits and Vegetables. Cancer Epidemiol Biomarkers Prev. 2004;13(5):843-9. PubMed PMID: 15159318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables. AU - Brevik,Asgeir, AU - Rasmussen,Salka Elbøl, AU - Drevon,Christian A, AU - Andersen,Lene Frost, PY - 2004/5/26/pubmed PY - 2004/9/8/medline PY - 2004/5/26/entrez SP - 843 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 5 N2 - BACKGROUND: Due to the random and systematic measurement errors associated with current dietary assessment instruments, there is a need to develop more objective methods of measuring the intake of foods of importance to human health. OBJECTIVE: The purpose of this study was to test whether urinary excretion of flavonoids could be used to identify subjects who are meeting Norwegian recommendations for fruit and vegetable intake (5 servings per day) from individuals who are consuming the national average amount of fruits and vegetables (2 servings per day). DESIGN: Twenty-four-hour urine samples were collected in a strict crossover controlled feeding study. Forty healthy subjects (19-34 years) were included in the study. After a 1-week run-in period, one group was given a controlled diet that included 2 servings (300 g) of fruits and vegetables daily for 14 days, while the other group was given a diet containing 5 servings (750 g) per day. Following a 2-week washout and a 1 week run-in period, the regimens were switched between the groups. RESULTS: An increased intake of mixed fruits and vegetables from 2 to 5 servings per day significantly enhanced urinary excretion of eriodictyol, naringenin, hesperetin, quercetin, kaempferol, isorhamnetin, and tamarixetin. The citrus flavonoids naringenin and hesperetin showed a steep dose-response relationship to dietary intake of fruits and vegetables, whereas the association to eriodictyol, quercetin, kaempferol, isorhamnetin, and tamarixetin was more moderate. CONCLUSION: The present study indicates that urinary excretion of dietary flavonoids may be used to assess changes of mixed fruit and vegetable intake corresponding to an increase from the present national intake in Norway to the recommended amount of 5 servings of fruits and vegetables daily. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15159318/Urinary_excretion_of_flavonoids_reflects_even_small_changes_in_the_dietary_intake_of_fruits_and_vegetables_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15159318 DB - PRIME DP - Unbound Medicine ER -