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Autonomic dysfunction in dementia with Lewy bodies.
Neurology. 2004 May 25; 62(10):1804-9.Neur

Abstract

OBJECTIVE

To assess autonomic function in patients with dementia with Lewy bodies (DLB).

METHODS

The authors compared data from 20 DLB patients evaluated from 1995 to 2000 to 20 age-matched multiple system atrophy (MSA) and Parkinson disease (PD) patients evaluated from 1999 to 2002. Analysis of variance, Fisher exact test, and Student t-test were applied to compare disease characteristics, autonomic symptoms, and function tests on the Composite Autonomic Scoring Scale (CASS) and Thermoregulatory Sweat Test (TST).

RESULTS

In DLB, mean age at onset of autonomic symptoms was 70.3 +/- 8.9 years. Orthostatic symptoms were common and orthostatic hypotension occurred in 10/20 DLB, 17/20 MSA, and 1/20 PD patients (p = 0.023, 0.003). CASS-sudomotor for DLB, MSA, and PD were 1.6 +/- 1.2, 2.5 +/- 0.7, and 0.9 +/- 0.8 (p < 0.00001). CASS-cardiovagal were 1.4 +/- 0.9, 2.1 +/- 0.8, and 0.7 +/- 0.6 (p < 0.00001). CASS-adrenergic function were 2.4 +/- 1.2, 3.5 +/- 0.9, and 0.5 +/- 0.6 (p < 0.00001). Total CASS were 5.2 +/- 2.0, 8.1 +/- 1.3, and 2.2 +/- 1.2 (p < 0.00001). The most common pattern of TST in DLB was distal anhidrosis. Mean duration of follow-up was 3.0 +/- 1.8 years. Six patients needed medication to maintain blood pressure and five had good response.

CONCLUSIONS

Autonomic dysfunction is frequent in dementia with Lewy bodies and the severity is intermediate between that of multiple system atrophy and Parkinson disease.

Authors+Show Affiliations

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15159482

Citation

Thaisetthawatkul, P, et al. "Autonomic Dysfunction in Dementia With Lewy Bodies." Neurology, vol. 62, no. 10, 2004, pp. 1804-9.
Thaisetthawatkul P, Boeve BF, Benarroch EE, et al. Autonomic dysfunction in dementia with Lewy bodies. Neurology. 2004;62(10):1804-9.
Thaisetthawatkul, P., Boeve, B. F., Benarroch, E. E., Sandroni, P., Ferman, T. J., Petersen, R., & Low, P. A. (2004). Autonomic dysfunction in dementia with Lewy bodies. Neurology, 62(10), 1804-9.
Thaisetthawatkul P, et al. Autonomic Dysfunction in Dementia With Lewy Bodies. Neurology. 2004 May 25;62(10):1804-9. PubMed PMID: 15159482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic dysfunction in dementia with Lewy bodies. AU - Thaisetthawatkul,P, AU - Boeve,B F, AU - Benarroch,E E, AU - Sandroni,P, AU - Ferman,T J, AU - Petersen,R, AU - Low,P A, PY - 2004/5/26/pubmed PY - 2004/10/27/medline PY - 2004/5/26/entrez SP - 1804 EP - 9 JF - Neurology JO - Neurology VL - 62 IS - 10 N2 - OBJECTIVE: To assess autonomic function in patients with dementia with Lewy bodies (DLB). METHODS: The authors compared data from 20 DLB patients evaluated from 1995 to 2000 to 20 age-matched multiple system atrophy (MSA) and Parkinson disease (PD) patients evaluated from 1999 to 2002. Analysis of variance, Fisher exact test, and Student t-test were applied to compare disease characteristics, autonomic symptoms, and function tests on the Composite Autonomic Scoring Scale (CASS) and Thermoregulatory Sweat Test (TST). RESULTS: In DLB, mean age at onset of autonomic symptoms was 70.3 +/- 8.9 years. Orthostatic symptoms were common and orthostatic hypotension occurred in 10/20 DLB, 17/20 MSA, and 1/20 PD patients (p = 0.023, 0.003). CASS-sudomotor for DLB, MSA, and PD were 1.6 +/- 1.2, 2.5 +/- 0.7, and 0.9 +/- 0.8 (p < 0.00001). CASS-cardiovagal were 1.4 +/- 0.9, 2.1 +/- 0.8, and 0.7 +/- 0.6 (p < 0.00001). CASS-adrenergic function were 2.4 +/- 1.2, 3.5 +/- 0.9, and 0.5 +/- 0.6 (p < 0.00001). Total CASS were 5.2 +/- 2.0, 8.1 +/- 1.3, and 2.2 +/- 1.2 (p < 0.00001). The most common pattern of TST in DLB was distal anhidrosis. Mean duration of follow-up was 3.0 +/- 1.8 years. Six patients needed medication to maintain blood pressure and five had good response. CONCLUSIONS: Autonomic dysfunction is frequent in dementia with Lewy bodies and the severity is intermediate between that of multiple system atrophy and Parkinson disease. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15159482/Autonomic_dysfunction_in_dementia_with_Lewy_bodies_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=15159482 DB - PRIME DP - Unbound Medicine ER -