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High protein diet complements resin therapy of familial hypercholesterolemia.
Clin Invest Med. 1992 Aug; 15(4):349-59.CI

Abstract

The intermediate-term effects on plasma lipoprotein lipids of substituting meat and dairy protein for carbohydrate in the diets of five subjects (three women, two men) with familial hypercholesterolemia receiving cholestyramine (mean dose, 18 g/d) were studied. Subjects were randomly allocated to either the high or low protein diets (mean 27 versus 10% of energy as protein, 25% as fat, and 48 versus 65% as carbohydrate) for 4 to 5 weeks and then switched to the other diet for another 4 to 5 weeks. Mean fasting plasma HDL cholesterol rose significantly by 17 +/- 3% (1.11 +/- 0.12 vs 0.95 +/- 0.11 mmol/L, p less than 0.005, n = 5), whereas total triglycerides fell by 23 +/- 2% (1.7 +/- 0.3 vs 2.2 +/- 0.3 mmol/L, p less than 0.005, n = 5), VLDL triglycerides fell by 28 +/- 5% (0.88 +/- 0.15 vs 1.18 +/- 0.19 mmol/L, p less than 0.02, n = 5), VLDL cholesterol fell by 32 +/- 7% (0.39 +/- 0.08 vs 0.56 +/- 0.09 mmol/L, p less than 0.01, n = 5), the ratio of LDL cholesterol: HDL cholesterol by 19 +/- 5% (4.7 +/- 0.7 vs 5.7 +/- 0.7, p less than 0.05) and that of total cholesterol: HDL cholesterol by 16 +/- 5% (6.6 +/- 0.5 vs 8.0 +/- 0.7, p less than 0.05) on the high versus low protein diet. Increasing dietary protein intake at the expense of carbohydrate may be useful in treating hypoalphalipoproteinemia and/or hypertriglyceridemia in patients with familial hypercholesterolemia.

Authors+Show Affiliations

Department of Medicine, University of Western Ontario, London.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1516292

Citation

Wolfe, B M., and P M. Giovannetti. "High Protein Diet Complements Resin Therapy of Familial Hypercholesterolemia." Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, vol. 15, no. 4, 1992, pp. 349-59.
Wolfe BM, Giovannetti PM. High protein diet complements resin therapy of familial hypercholesterolemia. Clin Invest Med. 1992;15(4):349-59.
Wolfe, B. M., & Giovannetti, P. M. (1992). High protein diet complements resin therapy of familial hypercholesterolemia. Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, 15(4), 349-59.
Wolfe BM, Giovannetti PM. High Protein Diet Complements Resin Therapy of Familial Hypercholesterolemia. Clin Invest Med. 1992;15(4):349-59. PubMed PMID: 1516292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High protein diet complements resin therapy of familial hypercholesterolemia. AU - Wolfe,B M, AU - Giovannetti,P M, PY - 1992/8/1/pubmed PY - 1992/8/1/medline PY - 1992/8/1/entrez SP - 349 EP - 59 JF - Clinical and investigative medicine. Medecine clinique et experimentale JO - Clin Invest Med VL - 15 IS - 4 N2 - The intermediate-term effects on plasma lipoprotein lipids of substituting meat and dairy protein for carbohydrate in the diets of five subjects (three women, two men) with familial hypercholesterolemia receiving cholestyramine (mean dose, 18 g/d) were studied. Subjects were randomly allocated to either the high or low protein diets (mean 27 versus 10% of energy as protein, 25% as fat, and 48 versus 65% as carbohydrate) for 4 to 5 weeks and then switched to the other diet for another 4 to 5 weeks. Mean fasting plasma HDL cholesterol rose significantly by 17 +/- 3% (1.11 +/- 0.12 vs 0.95 +/- 0.11 mmol/L, p less than 0.005, n = 5), whereas total triglycerides fell by 23 +/- 2% (1.7 +/- 0.3 vs 2.2 +/- 0.3 mmol/L, p less than 0.005, n = 5), VLDL triglycerides fell by 28 +/- 5% (0.88 +/- 0.15 vs 1.18 +/- 0.19 mmol/L, p less than 0.02, n = 5), VLDL cholesterol fell by 32 +/- 7% (0.39 +/- 0.08 vs 0.56 +/- 0.09 mmol/L, p less than 0.01, n = 5), the ratio of LDL cholesterol: HDL cholesterol by 19 +/- 5% (4.7 +/- 0.7 vs 5.7 +/- 0.7, p less than 0.05) and that of total cholesterol: HDL cholesterol by 16 +/- 5% (6.6 +/- 0.5 vs 8.0 +/- 0.7, p less than 0.05) on the high versus low protein diet. Increasing dietary protein intake at the expense of carbohydrate may be useful in treating hypoalphalipoproteinemia and/or hypertriglyceridemia in patients with familial hypercholesterolemia. SN - 0147-958X UR - https://www.unboundmedicine.com/medline/citation/1516292/High_protein_diet_complements_resin_therapy_of_familial_hypercholesterolemia_ L2 - http://www.diseaseinfosearch.org/result/2746 DB - PRIME DP - Unbound Medicine ER -