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The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe.
Helicobacter. 2004 Jun; 9(3):249-54.H

Abstract

BACKGROUND AND AIM

Helicobacter pylori is the major cause of peptic ulcer disease, but the proportion of H. pylori-negative peptic ulcers seems to be increasing in developed countries. We investigated the frequency of H. pylori-negative peptic ulcer without intake of nonsteroidal anti-inflammatory drugs (NSAIDs) in a Mediterranean European country.

MATERIALS AND METHODS

We prospectively collected consecutive patients with an endoscopically verified active peptic ulcer over 6 months from different areas of Spain. Helicobacter pylori infection was assessed by rapid urease test and histologic examination (corpus and antral biopsies). A (13)C-urea breath test was performed if H. pylori was not detected with the invasive test. Patients were considered H. pylori-negative if all three tests were negative. NSAID use was determined by structured data collection.

RESULTS

Of 754 consecutive peptic ulcer patients, 16 (2.1%) were H. pylori-negative and had not used NSAIDs before the diagnosis. Of the 472 patients who had duodenal ulcers, 95.7% (n = 452) were H. pylori-positive and only 1.69% (n = 8) were negative for both H. pylori infection and NSAID use; 193 patients had benign gastric ulcers and 87% (n = 168) of them were infected by H. pylori (p <.001 vs. duodenal ulcers). NSAID intake was more frequent in gastric ulcer patients (52.8%) than in duodenal ulcer patients (25.4%; p <.001). Consequently, the frequency of H. pylori-negative gastric ulcer in patients not using NSAID was 4.1% (n = 8).

CONCLUSION

Peptic ulcer disease is still highly associated with H. pylori infection in southern Europe, and only 1.6% of all duodenal ulcers and 4.1% of all gastric ulcers were not associated with either H. pylori infection or NSAID use.

Authors+Show Affiliations

Service of Gastroenterology, Hospital Clínico, Zaragoza, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15165261

Citation

Arroyo, M Teresa, et al. "The Prevalence of Peptic Ulcer Not Related to Helicobacter Pylori or Non-steroidal Anti-inflammatory Drug Use Is Negligible in Southern Europe." Helicobacter, vol. 9, no. 3, 2004, pp. 249-54.
Arroyo MT, Forne M, de Argila CM, et al. The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe. Helicobacter. 2004;9(3):249-54.
Arroyo, M. T., Forne, M., de Argila, C. M., Feu, F., Arenas, J., de la Vega, J., Garrigues, V., Mora, F., Castro, M., Bujanda, L., Cosme, A., Castiella, A., Gisbert, J. P., Hervas, A., & Lanas, A. (2004). The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe. Helicobacter, 9(3), 249-54.
Arroyo MT, et al. The Prevalence of Peptic Ulcer Not Related to Helicobacter Pylori or Non-steroidal Anti-inflammatory Drug Use Is Negligible in Southern Europe. Helicobacter. 2004;9(3):249-54. PubMed PMID: 15165261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe. AU - Arroyo,M Teresa, AU - Forne,Montse, AU - de Argila,Carlos Martin, AU - Feu,Faust, AU - Arenas,Juan, AU - de la Vega,Juan, AU - Garrigues,Vicente, AU - Mora,Francisco, AU - Castro,Manuel, AU - Bujanda,Luis, AU - Cosme,Angel, AU - Castiella,Agustín, AU - Gisbert,Javier P, AU - Hervas,Antonio, AU - Lanas,Angel, PY - 2004/5/29/pubmed PY - 2004/7/9/medline PY - 2004/5/29/entrez SP - 249 EP - 54 JF - Helicobacter JO - Helicobacter VL - 9 IS - 3 N2 - BACKGROUND AND AIM: Helicobacter pylori is the major cause of peptic ulcer disease, but the proportion of H. pylori-negative peptic ulcers seems to be increasing in developed countries. We investigated the frequency of H. pylori-negative peptic ulcer without intake of nonsteroidal anti-inflammatory drugs (NSAIDs) in a Mediterranean European country. MATERIALS AND METHODS: We prospectively collected consecutive patients with an endoscopically verified active peptic ulcer over 6 months from different areas of Spain. Helicobacter pylori infection was assessed by rapid urease test and histologic examination (corpus and antral biopsies). A (13)C-urea breath test was performed if H. pylori was not detected with the invasive test. Patients were considered H. pylori-negative if all three tests were negative. NSAID use was determined by structured data collection. RESULTS: Of 754 consecutive peptic ulcer patients, 16 (2.1%) were H. pylori-negative and had not used NSAIDs before the diagnosis. Of the 472 patients who had duodenal ulcers, 95.7% (n = 452) were H. pylori-positive and only 1.69% (n = 8) were negative for both H. pylori infection and NSAID use; 193 patients had benign gastric ulcers and 87% (n = 168) of them were infected by H. pylori (p <.001 vs. duodenal ulcers). NSAID intake was more frequent in gastric ulcer patients (52.8%) than in duodenal ulcer patients (25.4%; p <.001). Consequently, the frequency of H. pylori-negative gastric ulcer in patients not using NSAID was 4.1% (n = 8). CONCLUSION: Peptic ulcer disease is still highly associated with H. pylori infection in southern Europe, and only 1.6% of all duodenal ulcers and 4.1% of all gastric ulcers were not associated with either H. pylori infection or NSAID use. SN - 1083-4389 UR - https://www.unboundmedicine.com/medline/citation/15165261/The_prevalence_of_peptic_ulcer_not_related_to_Helicobacter_pylori_or_non_steroidal_anti_inflammatory_drug_use_is_negligible_in_southern_Europe_ L2 - https://doi.org/10.1111/j.1083-4389.2004.00219.x DB - PRIME DP - Unbound Medicine ER -