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Invasin and beyond: regulation of Yersinia virulence by RovA.
Trends Microbiol. 2004 Jun; 12(6):296-300.TM

Abstract

RovA, a member of the MarR/SlyA family of winged-helix transcription factors, regulates expression of invasin, the major adhesion and invasion factor in Yersinia enterocolitica and Yersinia pseudotuberculosis. Disruption of rovA increases the LD(50) of the organism when inoculated using the oral route. However, when administered by intraperitoneal injection only a slight difference in LD(50) between mutant and wild-type organisms is apparent. The study of RovA and the genes it regulates provides a unique opportunity to gain insight into the initial stages of a Yersinia infection.

Authors+Show Affiliations

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8230, St. Louis, MO 63110, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15165608

Citation

Ellison, Damon W., et al. "Invasin and Beyond: Regulation of Yersinia Virulence By RovA." Trends in Microbiology, vol. 12, no. 6, 2004, pp. 296-300.
Ellison DW, Lawrenz MB, Miller VL. Invasin and beyond: regulation of Yersinia virulence by RovA. Trends Microbiol. 2004;12(6):296-300.
Ellison, D. W., Lawrenz, M. B., & Miller, V. L. (2004). Invasin and beyond: regulation of Yersinia virulence by RovA. Trends in Microbiology, 12(6), 296-300.
Ellison DW, Lawrenz MB, Miller VL. Invasin and Beyond: Regulation of Yersinia Virulence By RovA. Trends Microbiol. 2004;12(6):296-300. PubMed PMID: 15165608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Invasin and beyond: regulation of Yersinia virulence by RovA. AU - Ellison,Damon W, AU - Lawrenz,Matthew B, AU - Miller,Virginia L, PY - 2004/5/29/pubmed PY - 2005/1/12/medline PY - 2004/5/29/entrez SP - 296 EP - 300 JF - Trends in microbiology JO - Trends Microbiol VL - 12 IS - 6 N2 - RovA, a member of the MarR/SlyA family of winged-helix transcription factors, regulates expression of invasin, the major adhesion and invasion factor in Yersinia enterocolitica and Yersinia pseudotuberculosis. Disruption of rovA increases the LD(50) of the organism when inoculated using the oral route. However, when administered by intraperitoneal injection only a slight difference in LD(50) between mutant and wild-type organisms is apparent. The study of RovA and the genes it regulates provides a unique opportunity to gain insight into the initial stages of a Yersinia infection. SN - 0966-842X UR - https://www.unboundmedicine.com/medline/citation/15165608/Invasin_and_beyond:_regulation_of_Yersinia_virulence_by_RovA_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966842X04000976 DB - PRIME DP - Unbound Medicine ER -