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Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia.
Nutrition. 2004 Jun; 20(6):521-7.N

Abstract

OBJECTIVE

Results from epidemiologic studies and clinical trials have indicated that consumption of omega-3 fatty acids, oleic acid, and folic acid have beneficial effects on health, including decreased risk of cardiovascular disease. We evaluated the combined effects of these nutrients through the consumption of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, vitamins E and B6, and folic acid on risk factors for cardiovascular disease in volunteers with mild hyperlipidemia.

METHODS

Thirty subjects ages 45 to 65 y (51.3 +/- 5.3 y) were given 500 mL/d of semi-skimmed milk for 4 wk and then 500 mL/d of the enriched milk for 8 wk. Plasma and low-density lipoproteins were obtained at the beginning of the study and at 4, 8, and 12 wk.

RESULTS

Consumption of enriched milk for 8 wk increased plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid and significantly (P < 0.05) decreased plasma concentrations of triacylglycerol (24%), total cholesterol (9%), and low-density lipoprotein cholesterol (13%). Plasma and low-density lipoprotein oxidation and vitamin E concentration remained unchanged throughout the study. Significant decreases in plasma concentrations of vascular cell adhesion molecule-1 (9%) and homocysteine (17%) were found, accompanied by a 98% increase in plasma concentration of folic acid.

CONCLUSIONS

Dairy supplementation strategies with omega-3 polyunsaturated fatty acids, oleic acid, and vitamins may be useful for decreasing risk factors for cardiovascular disease.

Authors+Show Affiliations

Carrero JJ
Puleva Biotech SA, Camino de Purchil, Granada, Spain.
Baró L
No affiliation info available
Fonollá J
No affiliation info available
González-Santiago M
No affiliation info available
Martínez-Férez A
No affiliation info available
Castillo R
No affiliation info available
Jiménez J
No affiliation info available
Boza JJ
No affiliation info available
López-Huertas E
No affiliation info available

MeSH

AgedAnimalsAntioxidantsCardiovascular DiseasesFatty Acids, Omega-3FemaleFolic AcidFood, FortifiedHomocysteineHumansHyperlipidemiasLipidsMaleMalondialdehydeMiddle AgedMilkOleic AcidRisk FactorsSpainTime FactorsVascular Cell Adhesion Molecule-1Vitamin B 6Vitamin B ComplexVitamin E

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15165614

Citation

Carrero, Juan J., et al. "Cardiovascular Effects of Milk Enriched With Omega-3 Polyunsaturated Fatty Acids, Oleic Acid, Folic Acid, and Vitamins E and B6 in Volunteers With Mild Hyperlipidemia." Nutrition (Burbank, Los Angeles County, Calif.), vol. 20, no. 6, 2004, pp. 521-7.
Carrero JJ, Baró L, Fonollá J, et al. Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia. Nutrition. 2004;20(6):521-7.
Carrero, J. J., Baró, L., Fonollá, J., González-Santiago, M., Martínez-Férez, A., Castillo, R., Jiménez, J., Boza, J. J., & López-Huertas, E. (2004). Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia. Nutrition (Burbank, Los Angeles County, Calif.), 20(6), 521-7.
Carrero JJ, et al. Cardiovascular Effects of Milk Enriched With Omega-3 Polyunsaturated Fatty Acids, Oleic Acid, Folic Acid, and Vitamins E and B6 in Volunteers With Mild Hyperlipidemia. Nutrition. 2004;20(6):521-7. PubMed PMID: 15165614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia. AU - Carrero,Juan J, AU - Baró,Luis, AU - Fonollá,Juristo, AU - González-Santiago,María, AU - Martínez-Férez,Antonio, AU - Castillo,Rafael, AU - Jiménez,Jesús, AU - Boza,Julio J, AU - López-Huertas,Eduardo, PY - 2004/5/29/pubmed PY - 2004/12/16/medline PY - 2004/5/29/entrez SP - 521 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 20 IS - 6 N2 - OBJECTIVE: Results from epidemiologic studies and clinical trials have indicated that consumption of omega-3 fatty acids, oleic acid, and folic acid have beneficial effects on health, including decreased risk of cardiovascular disease. We evaluated the combined effects of these nutrients through the consumption of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, vitamins E and B6, and folic acid on risk factors for cardiovascular disease in volunteers with mild hyperlipidemia. METHODS: Thirty subjects ages 45 to 65 y (51.3 +/- 5.3 y) were given 500 mL/d of semi-skimmed milk for 4 wk and then 500 mL/d of the enriched milk for 8 wk. Plasma and low-density lipoproteins were obtained at the beginning of the study and at 4, 8, and 12 wk. RESULTS: Consumption of enriched milk for 8 wk increased plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid and significantly (P < 0.05) decreased plasma concentrations of triacylglycerol (24%), total cholesterol (9%), and low-density lipoprotein cholesterol (13%). Plasma and low-density lipoprotein oxidation and vitamin E concentration remained unchanged throughout the study. Significant decreases in plasma concentrations of vascular cell adhesion molecule-1 (9%) and homocysteine (17%) were found, accompanied by a 98% increase in plasma concentration of folic acid. CONCLUSIONS: Dairy supplementation strategies with omega-3 polyunsaturated fatty acids, oleic acid, and vitamins may be useful for decreasing risk factors for cardiovascular disease. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/15165614/Cardiovascular_effects_of_milk_enriched_with_omega_3_polyunsaturated_fatty_acids_oleic_acid_folic_acid_and_vitamins_E_and_B6_in_volunteers_with_mild_hyperlipidemia_ DB - PRIME DP - Unbound Medicine ER -