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Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy.
Virology 2004; 323(1):24-36V

Abstract

Since the "bird flu" incident in Hong Kong SAR in 1997, several studies have highlighted the substantial role of domestic birds, such as turkeys and chickens, in the ecology of influenza A viruses. Even if recent evidence suggests that chickens can maintain several influenza serotypes, avian influenza viruses (AIVs) circulating in domestic species are believed to be introduced each time from the wild bird reservoir. However, so far the direct precursor of influenza viruses from domestic birds has never been identified. In this report, we describe the antigenic and genetic characterization of the surface proteins of H7N3 viruses isolated from wild ducks in Italy in 2001 in comparison to H7N3 strains that circulated in Italian turkeys in 2002-2003. The wild and domestic avian strains appeared strictly related at both phenotypic and genetic level: homology percentages in seven of their genes were comprised between 99.8% (for PB2) and 99.1% (for M), and their NA genes differed mainly because of a 23-aminoacid deletion in the NA stalk. Outside this region of the molecule, the NAs of the two virus groups showed 99% similarity. These findings indicate that turkey H7N3 viruses were derived "in toto" from avian influenza strains circulating in wild waterfowl 1 year earlier, and represent an important step towards the comprehension of the mechanisms leading to interspecies transmission and emergence of potentially pandemic influenza viruses.

Authors+Show Affiliations

Department of Virology, Istituto Superiore Sanita', Rome, Italy. campitel@iss.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15165816

Citation

Campitelli, Laura, et al. "Interspecies Transmission of an H7N3 Influenza Virus From Wild Birds to Intensively Reared Domestic Poultry in Italy." Virology, vol. 323, no. 1, 2004, pp. 24-36.
Campitelli L, Mogavero E, De Marco MA, et al. Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy. Virology. 2004;323(1):24-36.
Campitelli, L., Mogavero, E., De Marco, M. A., Delogu, M., Puzelli, S., Frezza, F., ... Donatelli, I. (2004). Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy. Virology, 323(1), pp. 24-36.
Campitelli L, et al. Interspecies Transmission of an H7N3 Influenza Virus From Wild Birds to Intensively Reared Domestic Poultry in Italy. Virology. 2004 May 20;323(1):24-36. PubMed PMID: 15165816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy. AU - Campitelli,Laura, AU - Mogavero,Elvira, AU - De Marco,Maria Alessandra, AU - Delogu,Mauro, AU - Puzelli,Simona, AU - Frezza,Fabiola, AU - Facchini,Marzia, AU - Chiapponi,Chiara, AU - Foni,Emanuela, AU - Cordioli,Paolo, AU - Webby,Richard, AU - Barigazzi,Giuseppe, AU - Webster,Robert G, AU - Donatelli,Isabella, PY - 2003/09/10/received PY - 2003/10/29/revised PY - 2004/02/17/accepted PY - 2004/5/29/pubmed PY - 2004/7/31/medline PY - 2004/5/29/entrez SP - 24 EP - 36 JF - Virology JO - Virology VL - 323 IS - 1 N2 - Since the "bird flu" incident in Hong Kong SAR in 1997, several studies have highlighted the substantial role of domestic birds, such as turkeys and chickens, in the ecology of influenza A viruses. Even if recent evidence suggests that chickens can maintain several influenza serotypes, avian influenza viruses (AIVs) circulating in domestic species are believed to be introduced each time from the wild bird reservoir. However, so far the direct precursor of influenza viruses from domestic birds has never been identified. In this report, we describe the antigenic and genetic characterization of the surface proteins of H7N3 viruses isolated from wild ducks in Italy in 2001 in comparison to H7N3 strains that circulated in Italian turkeys in 2002-2003. The wild and domestic avian strains appeared strictly related at both phenotypic and genetic level: homology percentages in seven of their genes were comprised between 99.8% (for PB2) and 99.1% (for M), and their NA genes differed mainly because of a 23-aminoacid deletion in the NA stalk. Outside this region of the molecule, the NAs of the two virus groups showed 99% similarity. These findings indicate that turkey H7N3 viruses were derived "in toto" from avian influenza strains circulating in wild waterfowl 1 year earlier, and represent an important step towards the comprehension of the mechanisms leading to interspecies transmission and emergence of potentially pandemic influenza viruses. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/15165816/Interspecies_transmission_of_an_H7N3_influenza_virus_from_wild_birds_to_intensively_reared_domestic_poultry_in_Italy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042682204001424 DB - PRIME DP - Unbound Medicine ER -