Tags

Type your tag names separated by a space and hit enter

Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial.

Abstract

OBJECTIVE

Many studies have shown that soy isoflavones have an effect in preventing estrogen-related bone loss, but no data reported whether such an effect could be influenced by other important factors affecting bone loss. This study examines whether the associations between isoflavone supplementation and rates of change in bone mineral content (BMC) could be modified by years since menopause (YSM), body weight (BW), and dietary calcium intake in postmenopausal Chinese women aged 48 to 62 years.

DESIGN

A group of 203 eligible women were randomly assigned to three treatment groups: placebo (daily dose of 0 mg isoflavones + 500 mg calcium, n = 67), mid-dose (40 mg isoflavones + 500 mg calcium, n = 68); and high-dose (80 mg isoflavones + 500 mg calcium, n = 68). Bone mineral density (BMD) and BMC at the whole body, spine, and hip were measured by dual-energy x-ray absorptiometry at baseline and posttreatment after 1 year. YSM, BW, and dietary calcium intake stratified analyses were performed to evaluate whether the associations between isoflavones supplementation and BMC change rates were varied with these factors.

RESULTS

Both univariate and multivariate analyses observed significant favorable effect of isoflavone supplementation on rates of change in BMC at the total hip and trochanter among later postmenopausal women (> 4 y), in women with lower BW (< or =median, 55.5 kg), or among women with lower level of calcium intake (< or =median, 1095 mg/d).

CONCLUSIONS

The independent effect of soy on the maintenance of hip BMC is more marked in women in later menopause or those with lower BW or calcium intake.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Community and Family Medicine, School of Pharmacy, the Chinese University of Hong Kong, China.

    , , ,

    Source

    MeSH

    Absorptiometry, Photon
    Body Weight
    Bone Density
    Calcium, Dietary
    Dietary Supplements
    Female
    Humans
    Isoflavones
    Middle Aged
    Osteoporosis, Postmenopausal
    Phytotherapy
    Soybean Proteins
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15167303

    Citation

    Chen, Yu-Ming, et al. "Beneficial Effect of Soy Isoflavones On Bone Mineral Content Was Modified By Years Since Menopause, Body Weight, and Calcium Intake: a Double-blind, Randomized, Controlled Trial." Menopause (New York, N.Y.), vol. 11, no. 3, 2004, pp. 246-54.
    Chen YM, Ho SC, Lam SS, et al. Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. Menopause. 2004;11(3):246-54.
    Chen, Y. M., Ho, S. C., Lam, S. S., Ho, S. S., & Woo, J. L. (2004). Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. Menopause (New York, N.Y.), 11(3), pp. 246-54.
    Chen YM, et al. Beneficial Effect of Soy Isoflavones On Bone Mineral Content Was Modified By Years Since Menopause, Body Weight, and Calcium Intake: a Double-blind, Randomized, Controlled Trial. Menopause. 2004;11(3):246-54. PubMed PMID: 15167303.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. AU - Chen,Yu-Ming, AU - Ho,Suzanne C, AU - Lam,Silvia S H, AU - Ho,Susan S S, AU - Woo,Jean L F, PY - 2004/5/29/pubmed PY - 2004/8/20/medline PY - 2004/5/29/entrez SP - 246 EP - 54 JF - Menopause (New York, N.Y.) JO - Menopause VL - 11 IS - 3 N2 - OBJECTIVE: Many studies have shown that soy isoflavones have an effect in preventing estrogen-related bone loss, but no data reported whether such an effect could be influenced by other important factors affecting bone loss. This study examines whether the associations between isoflavone supplementation and rates of change in bone mineral content (BMC) could be modified by years since menopause (YSM), body weight (BW), and dietary calcium intake in postmenopausal Chinese women aged 48 to 62 years. DESIGN: A group of 203 eligible women were randomly assigned to three treatment groups: placebo (daily dose of 0 mg isoflavones + 500 mg calcium, n = 67), mid-dose (40 mg isoflavones + 500 mg calcium, n = 68); and high-dose (80 mg isoflavones + 500 mg calcium, n = 68). Bone mineral density (BMD) and BMC at the whole body, spine, and hip were measured by dual-energy x-ray absorptiometry at baseline and posttreatment after 1 year. YSM, BW, and dietary calcium intake stratified analyses were performed to evaluate whether the associations between isoflavones supplementation and BMC change rates were varied with these factors. RESULTS: Both univariate and multivariate analyses observed significant favorable effect of isoflavone supplementation on rates of change in BMC at the total hip and trochanter among later postmenopausal women (> 4 y), in women with lower BW (< or =median, 55.5 kg), or among women with lower level of calcium intake (< or =median, 1095 mg/d). CONCLUSIONS: The independent effect of soy on the maintenance of hip BMC is more marked in women in later menopause or those with lower BW or calcium intake. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/15167303/Beneficial_effect_of_soy_isoflavones_on_bone_mineral_content_was_modified_by_years_since_menopause_body_weight_and_calcium_intake:_a_double_blind_randomized_controlled_trial_ L2 - http://Insights.ovid.com/pubmed?pmid=15167303 DB - PRIME DP - Unbound Medicine ER -