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The effect of soy protein isolate on bone metabolism.
Menopause 2004 May-Jun; 11(3):290-8M

Abstract

OBJECTIVE

This double-blind, 15-month pilot study was designed to investigate the effect of soy protein isolate with varying concentrations of isoflavones on early postmenopausal bone loss and lipids.

DESIGN

A total of 65 women, with a mean age of 55 years and 7.5 years since menopause, were randomized to one of three groups; soy protein with 96 mg isoflavones/day, soy with 52 mg isoflavones/day, or soy without isoflavones (< 4 mg isoflavones/day). Soy was given for 9 months and then discontinued; participants were followed for an additional 6 months. Bone mineral density (BMD) and blood lipids were measured during this time.

RESULTS

Measurement of serum isoflavones at 3 months showed dose-related increases in the three groups. There was no significant effect of the soy supplements on BMD of the spine or femoral neck in any of the three groups. BMD increased significantly in the trochanter at 9 months (P = 0.0219) and at 15 months (P < 0.05) in the group given isoflavone-free soy compared with the other two groups. There was no significant effect of soy on lipid metabolism at the end of the intervention.

CONCLUSION

The present study did not find a significant positive effect of soy protein isolate supplemented with isoflavones on BMD and the serum lipid profile in early postmenopausal women.

Authors+Show Affiliations

Bone Metabolism Unit, School of Medicine and the Osteoporosis Research Center, Creighton University, Omaha, NE, USA. jcg@creighton.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15167308

Citation

Gallagher, J Christopher, et al. "The Effect of Soy Protein Isolate On Bone Metabolism." Menopause (New York, N.Y.), vol. 11, no. 3, 2004, pp. 290-8.
Gallagher JC, Satpathy R, Rafferty K, et al. The effect of soy protein isolate on bone metabolism. Menopause. 2004;11(3):290-8.
Gallagher, J. C., Satpathy, R., Rafferty, K., & Haynatzka, V. (2004). The effect of soy protein isolate on bone metabolism. Menopause (New York, N.Y.), 11(3), pp. 290-8.
Gallagher JC, et al. The Effect of Soy Protein Isolate On Bone Metabolism. Menopause. 2004;11(3):290-8. PubMed PMID: 15167308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of soy protein isolate on bone metabolism. AU - Gallagher,J Christopher, AU - Satpathy,Ruby, AU - Rafferty,Karen, AU - Haynatzka,Vera, PY - 2004/5/29/pubmed PY - 2004/8/20/medline PY - 2004/5/29/entrez SP - 290 EP - 8 JF - Menopause (New York, N.Y.) JO - Menopause VL - 11 IS - 3 N2 - OBJECTIVE: This double-blind, 15-month pilot study was designed to investigate the effect of soy protein isolate with varying concentrations of isoflavones on early postmenopausal bone loss and lipids. DESIGN: A total of 65 women, with a mean age of 55 years and 7.5 years since menopause, were randomized to one of three groups; soy protein with 96 mg isoflavones/day, soy with 52 mg isoflavones/day, or soy without isoflavones (< 4 mg isoflavones/day). Soy was given for 9 months and then discontinued; participants were followed for an additional 6 months. Bone mineral density (BMD) and blood lipids were measured during this time. RESULTS: Measurement of serum isoflavones at 3 months showed dose-related increases in the three groups. There was no significant effect of the soy supplements on BMD of the spine or femoral neck in any of the three groups. BMD increased significantly in the trochanter at 9 months (P = 0.0219) and at 15 months (P < 0.05) in the group given isoflavone-free soy compared with the other two groups. There was no significant effect of soy on lipid metabolism at the end of the intervention. CONCLUSION: The present study did not find a significant positive effect of soy protein isolate supplemented with isoflavones on BMD and the serum lipid profile in early postmenopausal women. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/15167308/The_effect_of_soy_protein_isolate_on_bone_metabolism_ L2 - http://Insights.ovid.com/pubmed?pmid=15167308 DB - PRIME DP - Unbound Medicine ER -