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Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways.
Inflamm Res. 2004 Jun; 53(6):230-8.IR

Abstract

OBJECTIVE

The aim of this study was to analyze a possible contribution of human neutrophil defensins and secretory leukocyte proteinase inhibitor (SLPI) to the induction of airway epithelial changes such as squamous cell metaplasia.

MATERIALS AND METHODS

The presence of these molecules and the number of proliferating (Ki-67-positive) epithelial cells was analyzed by immunohistochemistry in bronchial epithelium from subjects with (n = 15) or without (n = 14) chronic obstructive pulmonary disease (COPD).

RESULTS

Our data demonstrate higher numbers of defensin-positive (p = 0.0001), elastase-positive (p = 0.0001) and Ki-67-positive (p = 0.0001) cells in areas with squamous cell metaplasia as compared to areas with intact or damaged epithelium, while the reverse was observed for SLPI expression (p = 0.002). No differences were observed between subjects with or without COPD, nor between current smokers and those that had stopped smoking.

CONCLUSIONS

These data are in line with a role of defensins in the hyperproliferative phenotype of squamous metaplastic lesions in the airways. This role does not seem to be restricted to patients with COPD.

Authors+Show Affiliations

Department of Pulmonology, C3-P, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15167969

Citation

Aarbiou, J, et al. "Human Neutrophil Defensins and Secretory Leukocyte Proteinase Inhibitor in Squamous Metaplastic Epithelium of Bronchial Airways." Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.], vol. 53, no. 6, 2004, pp. 230-8.
Aarbiou J, van Schadewijk A, Stolk J, et al. Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways. Inflamm Res. 2004;53(6):230-8.
Aarbiou, J., van Schadewijk, A., Stolk, J., Sont, J. K., de Boer, W. I., Rabe, K. F., van Krieken, J. H., Mauad, T., & Hiemstra, P. S. (2004). Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways. Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.], 53(6), 230-8.
Aarbiou J, et al. Human Neutrophil Defensins and Secretory Leukocyte Proteinase Inhibitor in Squamous Metaplastic Epithelium of Bronchial Airways. Inflamm Res. 2004;53(6):230-8. PubMed PMID: 15167969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways. AU - Aarbiou,J, AU - van Schadewijk,A, AU - Stolk,J, AU - Sont,J K, AU - de Boer,W I, AU - Rabe,K F, AU - van Krieken,J H J M, AU - Mauad,T, AU - Hiemstra,P S, Y1 - 2004/05/12/ PY - 2003/09/25/received PY - 2003/12/22/accepted PY - 2004/5/29/pubmed PY - 2005/1/7/medline PY - 2004/5/29/entrez SP - 230 EP - 8 JF - Inflammation research : official journal of the European Histamine Research Society ... [et al.] JO - Inflamm Res VL - 53 IS - 6 N2 - OBJECTIVE: The aim of this study was to analyze a possible contribution of human neutrophil defensins and secretory leukocyte proteinase inhibitor (SLPI) to the induction of airway epithelial changes such as squamous cell metaplasia. MATERIALS AND METHODS: The presence of these molecules and the number of proliferating (Ki-67-positive) epithelial cells was analyzed by immunohistochemistry in bronchial epithelium from subjects with (n = 15) or without (n = 14) chronic obstructive pulmonary disease (COPD). RESULTS: Our data demonstrate higher numbers of defensin-positive (p = 0.0001), elastase-positive (p = 0.0001) and Ki-67-positive (p = 0.0001) cells in areas with squamous cell metaplasia as compared to areas with intact or damaged epithelium, while the reverse was observed for SLPI expression (p = 0.002). No differences were observed between subjects with or without COPD, nor between current smokers and those that had stopped smoking. CONCLUSIONS: These data are in line with a role of defensins in the hyperproliferative phenotype of squamous metaplastic lesions in the airways. This role does not seem to be restricted to patients with COPD. SN - 1023-3830 UR - https://www.unboundmedicine.com/medline/citation/15167969/Human_neutrophil_defensins_and_secretory_leukocyte_proteinase_inhibitor_in_squamous_metaplastic_epithelium_of_bronchial_airways_ L2 - https://dx.doi.org/10.1007/s00011-003-1240-x DB - PRIME DP - Unbound Medicine ER -