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[Comparative study of itraconazole and fluconazole therapy in vaginal candidosis].
Akush Ginekol (Sofiia). 2004; 43(1):20-3.AG

Abstract

Women who had symptomatic acute vulvovaginal candidiasis are include in this study. Micological investigation is realized by microscopy, culture method (CHROM agar, BD, USA) and ID 32 C (Fungus), Mini API Bio Merieux, France. Most frequent isolates are Candida albicans (82.67%), followed by C. glabrata (7.8%) and C. parapsilosis (5.51%). We compare two groups of patients: received itraconazole (200 mg bd oral dose for 1 day) and fluconazole (150 mg single oral dose). The rate of mycological cure is 93.8% in the itraconazole group and 79.03% in the fluconazole group (p = 0.008). Clinical response rate for women receiving itraconazole (80%) is significantly higher than fluconazole group (59.7%). These results suggests that itraconazole is more effective than fluconazole in the treatment of acute vulvovaginal candidiasis.

Authors+Show Affiliations

Department of Microbiology and Virology, Department of General and Oncological Gynecology, Military Medical Academy-Sofia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article

Language

bul

PubMed ID

15168649

Citation

Vacheva-Dobrevski, R, et al. "[Comparative Study of Itraconazole and Fluconazole Therapy in Vaginal Candidosis]." Akusherstvo I Ginekologiia, vol. 43, no. 1, 2004, pp. 20-3.
Vacheva-Dobrevski R, Kovachev S, Nacheva A, et al. [Comparative study of itraconazole and fluconazole therapy in vaginal candidosis]. Akush Ginekol (Sofiia). 2004;43(1):20-3.
Vacheva-Dobrevski, R., Kovachev, S., Nacheva, A., Stoev, S., & Vasilev, N. (2004). [Comparative study of itraconazole and fluconazole therapy in vaginal candidosis]. Akusherstvo I Ginekologiia, 43(1), 20-3.
Vacheva-Dobrevski R, et al. [Comparative Study of Itraconazole and Fluconazole Therapy in Vaginal Candidosis]. Akush Ginekol (Sofiia). 2004;43(1):20-3. PubMed PMID: 15168649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative study of itraconazole and fluconazole therapy in vaginal candidosis]. AU - Vacheva-Dobrevski,R, AU - Kovachev,S, AU - Nacheva,A, AU - Stoev,S, AU - Vasilev,N, PY - 2004/6/1/pubmed PY - 2004/8/24/medline PY - 2004/6/1/entrez SP - 20 EP - 3 JF - Akusherstvo i ginekologiia JO - Akush Ginekol (Sofiia) VL - 43 IS - 1 N2 - Women who had symptomatic acute vulvovaginal candidiasis are include in this study. Micological investigation is realized by microscopy, culture method (CHROM agar, BD, USA) and ID 32 C (Fungus), Mini API Bio Merieux, France. Most frequent isolates are Candida albicans (82.67%), followed by C. glabrata (7.8%) and C. parapsilosis (5.51%). We compare two groups of patients: received itraconazole (200 mg bd oral dose for 1 day) and fluconazole (150 mg single oral dose). The rate of mycological cure is 93.8% in the itraconazole group and 79.03% in the fluconazole group (p = 0.008). Clinical response rate for women receiving itraconazole (80%) is significantly higher than fluconazole group (59.7%). These results suggests that itraconazole is more effective than fluconazole in the treatment of acute vulvovaginal candidiasis. SN - 0324-0959 UR - https://www.unboundmedicine.com/medline/citation/15168649/[Comparative_study_of_itraconazole_and_fluconazole_therapy_in_vaginal_candidosis]_ DB - PRIME DP - Unbound Medicine ER -