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High rate of spontaneous clearance of acute hepatitis C virus genotype 3 infection.
J Med Virol. 2004 Jul; 73(3):387-91.JM

Abstract

Treating acute hepatitis C with interferon alpha prevents chronicity in nearly all cases when therapy is initiated within 3 months after infection. However, 15-50% of untreated patients may clear the hepatitis C virus (HCV) spontaneously. Therefore, factors are needed to identify patients prior to therapy who have a higher or lower risk for developing a chronic course to avoid unnecessary treatment. The role of the HCV genotype for spontaneous recovery from acute hepatitis C has been discussed controversially. In the year 2002, all 1,176 new incoming prisoners in a Northern German prison for young men (age 16-24) were screened for anti-HCV antibodies and 92 tested positive. Ninety eight percent of these reported i.v.-drug abuse for a median of 32 months prior to imprisonment. HCV-RNA negative individuals (21%) were serotyped and HCV-RNA positive patients were genotyped. The prevalence of HCV genotype 3 was significantly higher among individuals who had cleared HCV spontaneously as compared to chronically infected patients (86% vs. 38%; P = 0.002). Ninety three percent of individuals exposed to HCV genotype 1 but only 63% of individuals exposed to genotype 3 experienced a chronic course of the infection (P = 0.006). Thus, acute infection in young Caucasian men with HCV genotype 3 leads more often to spontaneous clearance than infection with HCV genotype-1. Considering also the high chance of successful treatment of chronic HCV genotype 3 infection with pegylated-interferon in combination with ribavirin, we suggest not to treat acute hepatitis C genotype 3 infection early but rather to wait at least 3 months after the onset of symptoms when chronicity becomes likely.

Authors+Show Affiliations

Jugendanstalt Hameln, Hameln, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15170633

Citation

Lehmann, Marc, et al. "High Rate of Spontaneous Clearance of Acute Hepatitis C Virus Genotype 3 Infection." Journal of Medical Virology, vol. 73, no. 3, 2004, pp. 387-91.
Lehmann M, Meyer MF, Monazahian M, et al. High rate of spontaneous clearance of acute hepatitis C virus genotype 3 infection. J Med Virol. 2004;73(3):387-91.
Lehmann, M., Meyer, M. F., Monazahian, M., Tillmann, H. L., Manns, M. P., & Wedemeyer, H. (2004). High rate of spontaneous clearance of acute hepatitis C virus genotype 3 infection. Journal of Medical Virology, 73(3), 387-91.
Lehmann M, et al. High Rate of Spontaneous Clearance of Acute Hepatitis C Virus Genotype 3 Infection. J Med Virol. 2004;73(3):387-91. PubMed PMID: 15170633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High rate of spontaneous clearance of acute hepatitis C virus genotype 3 infection. AU - Lehmann,Marc, AU - Meyer,Manuela F, AU - Monazahian,Masyar, AU - Tillmann,Hans L, AU - Manns,Michael P, AU - Wedemeyer,Heiner, PY - 2004/6/2/pubmed PY - 2004/12/22/medline PY - 2004/6/2/entrez SP - 387 EP - 91 JF - Journal of medical virology JO - J Med Virol VL - 73 IS - 3 N2 - Treating acute hepatitis C with interferon alpha prevents chronicity in nearly all cases when therapy is initiated within 3 months after infection. However, 15-50% of untreated patients may clear the hepatitis C virus (HCV) spontaneously. Therefore, factors are needed to identify patients prior to therapy who have a higher or lower risk for developing a chronic course to avoid unnecessary treatment. The role of the HCV genotype for spontaneous recovery from acute hepatitis C has been discussed controversially. In the year 2002, all 1,176 new incoming prisoners in a Northern German prison for young men (age 16-24) were screened for anti-HCV antibodies and 92 tested positive. Ninety eight percent of these reported i.v.-drug abuse for a median of 32 months prior to imprisonment. HCV-RNA negative individuals (21%) were serotyped and HCV-RNA positive patients were genotyped. The prevalence of HCV genotype 3 was significantly higher among individuals who had cleared HCV spontaneously as compared to chronically infected patients (86% vs. 38%; P = 0.002). Ninety three percent of individuals exposed to HCV genotype 1 but only 63% of individuals exposed to genotype 3 experienced a chronic course of the infection (P = 0.006). Thus, acute infection in young Caucasian men with HCV genotype 3 leads more often to spontaneous clearance than infection with HCV genotype-1. Considering also the high chance of successful treatment of chronic HCV genotype 3 infection with pegylated-interferon in combination with ribavirin, we suggest not to treat acute hepatitis C genotype 3 infection early but rather to wait at least 3 months after the onset of symptoms when chronicity becomes likely. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/15170633/High_rate_of_spontaneous_clearance_of_acute_hepatitis_C_virus_genotype_3_infection_ L2 - https://doi.org/10.1002/jmv.20103 DB - PRIME DP - Unbound Medicine ER -