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Symptoms, lung function, and beta2-adrenoceptor polymorphisms in a birth cohort followed for 10 years.
Pediatr Pulmonol. 2004 Jul; 38(1):75-81.PP

Abstract

As little is known about the natural history of bronchial responsiveness and the development of wheezing symptoms in early childhood, a cohort of children at risk of allergy, whose lung function and bronchial responsiveness had been measured in the neonatal period, was followed prospectively for 10 (SD, 0.8) years in order to determine the role of neonatal measurements on wheezing history and later lung function. A potential role for beta-2 adrenoceptor (beta2AR) polymorphisms in these relationships was also sought as a secondary objective. Of the original 73 children, wheezing history was available in 65 (89%), and 49 (67%) attended the laboratory for physiological measurements and genotyping of beta2AR. Wheezing was categorized as occurring 1) only before the fourth birthday, 2) after the fourth birthday, or 3) never. No relation was seen between neonatal and later lung function. However, neonatal bronchial responsiveness predicted subsequent FEV1 (P = 0.03). Increased neonatal bronchial responsiveness was associated with transient wheeze <4 years but not with later wheeze. Neonatal V'maxFRC was reduced in those possessing Gln27 or Arg16 alleles, but there was no effect of beta2AR polymorphisms on FEV1 at 10 years. Wheeze after 4 years of age was typical of classical asthma, as it was strongly related to atopy and bronchial responsiveness at age 10. In conclusion, we confirmed the association of neonatal bronchial responsiveness with both early wheezing and later lung function. We also showed an influence of polymorphisms at both aa16 and aa27 on neonatal lung function. Wheezing beyond 4 years, typical of classical asthma, was unrelated to early measurements of lung function or bronchial responsiveness.

Authors+Show Affiliations

Department of Paediatrics, National Heart and Lung Institute, London, UK. n.wilson@rbh.nthames.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15170877

Citation

Wilson, Nicola M., et al. "Symptoms, Lung Function, and Beta2-adrenoceptor Polymorphisms in a Birth Cohort Followed for 10 Years." Pediatric Pulmonology, vol. 38, no. 1, 2004, pp. 75-81.
Wilson NM, Lamprill JR, Mak JC, et al. Symptoms, lung function, and beta2-adrenoceptor polymorphisms in a birth cohort followed for 10 years. Pediatr Pulmonol. 2004;38(1):75-81.
Wilson, N. M., Lamprill, J. R., Mak, J. C., Clarke, J. R., Bush, A., & Silverman, M. (2004). Symptoms, lung function, and beta2-adrenoceptor polymorphisms in a birth cohort followed for 10 years. Pediatric Pulmonology, 38(1), 75-81.
Wilson NM, et al. Symptoms, Lung Function, and Beta2-adrenoceptor Polymorphisms in a Birth Cohort Followed for 10 Years. Pediatr Pulmonol. 2004;38(1):75-81. PubMed PMID: 15170877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Symptoms, lung function, and beta2-adrenoceptor polymorphisms in a birth cohort followed for 10 years. AU - Wilson,Nicola M, AU - Lamprill,Jane R, AU - Mak,Judith C W, AU - Clarke,Jane R, AU - Bush,Andrew, AU - Silverman,Michael, PY - 2004/6/2/pubmed PY - 2004/10/27/medline PY - 2004/6/2/entrez SP - 75 EP - 81 JF - Pediatric pulmonology JO - Pediatr Pulmonol VL - 38 IS - 1 N2 - As little is known about the natural history of bronchial responsiveness and the development of wheezing symptoms in early childhood, a cohort of children at risk of allergy, whose lung function and bronchial responsiveness had been measured in the neonatal period, was followed prospectively for 10 (SD, 0.8) years in order to determine the role of neonatal measurements on wheezing history and later lung function. A potential role for beta-2 adrenoceptor (beta2AR) polymorphisms in these relationships was also sought as a secondary objective. Of the original 73 children, wheezing history was available in 65 (89%), and 49 (67%) attended the laboratory for physiological measurements and genotyping of beta2AR. Wheezing was categorized as occurring 1) only before the fourth birthday, 2) after the fourth birthday, or 3) never. No relation was seen between neonatal and later lung function. However, neonatal bronchial responsiveness predicted subsequent FEV1 (P = 0.03). Increased neonatal bronchial responsiveness was associated with transient wheeze <4 years but not with later wheeze. Neonatal V'maxFRC was reduced in those possessing Gln27 or Arg16 alleles, but there was no effect of beta2AR polymorphisms on FEV1 at 10 years. Wheeze after 4 years of age was typical of classical asthma, as it was strongly related to atopy and bronchial responsiveness at age 10. In conclusion, we confirmed the association of neonatal bronchial responsiveness with both early wheezing and later lung function. We also showed an influence of polymorphisms at both aa16 and aa27 on neonatal lung function. Wheezing beyond 4 years, typical of classical asthma, was unrelated to early measurements of lung function or bronchial responsiveness. SN - 8755-6863 UR - https://www.unboundmedicine.com/medline/citation/15170877/Symptoms_lung_function_and_beta2_adrenoceptor_polymorphisms_in_a_birth_cohort_followed_for_10_years_ L2 - https://doi.org/10.1002/ppul.20049 DB - PRIME DP - Unbound Medicine ER -