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CD19 negative precursor B acute lymphoblastic leukemia presenting with hypercalcemia.
Pediatr Blood Cancer. 2004 Jul; 43(1):66-9.PB

Abstract

A 9-month-old infant presented with hypercalcemia and lytic bone lesions. Suspicion for malignancy led to a bone marrow examination, which showed replacement of the marrow by a small round blue cell infiltrate. Flow cytometric analysis of these cells showed an unusual immunophenotype in that these cells were dim CD45, HLA-DR, and CD10 positive, but CD19, CD20, CD79a, and CD34 negative. Southern blotting showed clonal rearrangement of immunoglobulin heavy chain (IgH) which confirmed a diagnosis of precursor B acute lymphoblastic leukemia (ALL). He received supportive treatment with hydration and pamidronate, but had recurrent episodes of hypercalcemia. Once the correct diagnosis of ALL was established, the patient was treated with an infantile ALL chemotherapeutic regimen and the hypercalcemia resolved. This case highlights the usefulness of immunoglobulin gene rearrangement studies in atypical cases of ALL.

Authors+Show Affiliations

Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, 29425, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15170892

Citation

Sultan, Iyad, et al. "CD19 Negative Precursor B Acute Lymphoblastic Leukemia Presenting With Hypercalcemia." Pediatric Blood & Cancer, vol. 43, no. 1, 2004, pp. 66-9.
Sultan I, Kraveka JM, Lazarchick J. CD19 negative precursor B acute lymphoblastic leukemia presenting with hypercalcemia. Pediatr Blood Cancer. 2004;43(1):66-9.
Sultan, I., Kraveka, J. M., & Lazarchick, J. (2004). CD19 negative precursor B acute lymphoblastic leukemia presenting with hypercalcemia. Pediatric Blood & Cancer, 43(1), 66-9.
Sultan I, Kraveka JM, Lazarchick J. CD19 Negative Precursor B Acute Lymphoblastic Leukemia Presenting With Hypercalcemia. Pediatr Blood Cancer. 2004;43(1):66-9. PubMed PMID: 15170892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD19 negative precursor B acute lymphoblastic leukemia presenting with hypercalcemia. AU - Sultan,Iyad, AU - Kraveka,Jacqueline M, AU - Lazarchick,John, PY - 2004/6/2/pubmed PY - 2004/7/15/medline PY - 2004/6/2/entrez SP - 66 EP - 9 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 43 IS - 1 N2 - A 9-month-old infant presented with hypercalcemia and lytic bone lesions. Suspicion for malignancy led to a bone marrow examination, which showed replacement of the marrow by a small round blue cell infiltrate. Flow cytometric analysis of these cells showed an unusual immunophenotype in that these cells were dim CD45, HLA-DR, and CD10 positive, but CD19, CD20, CD79a, and CD34 negative. Southern blotting showed clonal rearrangement of immunoglobulin heavy chain (IgH) which confirmed a diagnosis of precursor B acute lymphoblastic leukemia (ALL). He received supportive treatment with hydration and pamidronate, but had recurrent episodes of hypercalcemia. Once the correct diagnosis of ALL was established, the patient was treated with an infantile ALL chemotherapeutic regimen and the hypercalcemia resolved. This case highlights the usefulness of immunoglobulin gene rearrangement studies in atypical cases of ALL. SN - 1545-5009 UR - https://www.unboundmedicine.com/medline/citation/15170892/CD19_negative_precursor_B_acute_lymphoblastic_leukemia_presenting_with_hypercalcemia_ L2 - https://doi.org/10.1002/pbc.20063 DB - PRIME DP - Unbound Medicine ER -