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Different progressions of hyperglycemia and diabetes among hyperuricemic men and women in the kinmen study.
J Rheumatol. 2004 Jun; 31(6):1159-65.JR

Abstract

OBJECTIVE

A 7-year followup study among hyperuricemic subjects was conducted to investigate the association between longterm hyperuricemia and subsequent hyperglycemia and diabetes mellitus. The possible sex difference was also investigated.

METHODS

A total of 641 hyperuricemic subjects aged 30 years and over (391 men, 250 women) screened from the community-based Kinmen Study in 1991-92 (the baseline study) were followed in 1997-98, with 75% followup rate. Demographic, clinical, and biochemical data were collected in both baseline and followup periods.

RESULTS

After followup for 7 years, the distribution of plasma glucose concentrations changed moderately among male hyperuricemic subjects, but increased markedly among female subjects. The increase of uric acid levels during the followup period was correlated with subsequent diabetes only among hyperuricemic women. Moreover, a relatively higher incidence of diabetes was found in postmenopausal hyperuricemic women after 7-year followup.

CONCLUSION

Although the direct role and causality played by uric acid cannot be confirmed by this study, the findings, as applicable to a Chinese nondiabetic population, show that specific progressions of plasma glucose concentrations were significantly different between male and female hyperuricemic subjects. Hyperuricemia and persistent increase in uric acid levels among postmenopausal women should alert physicians to the possibility of subsequent hyperglycemia and diabetes.

Authors+Show Affiliations

Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15170930

Citation

Lin, Kuan-Chia, et al. "Different Progressions of Hyperglycemia and Diabetes Among Hyperuricemic Men and Women in the Kinmen Study." The Journal of Rheumatology, vol. 31, no. 6, 2004, pp. 1159-65.
Lin KC, Tsai ST, Lin HY, et al. Different progressions of hyperglycemia and diabetes among hyperuricemic men and women in the kinmen study. J Rheumatol. 2004;31(6):1159-65.
Lin, K. C., Tsai, S. T., Lin, H. Y., & Chou, P. (2004). Different progressions of hyperglycemia and diabetes among hyperuricemic men and women in the kinmen study. The Journal of Rheumatology, 31(6), 1159-65.
Lin KC, et al. Different Progressions of Hyperglycemia and Diabetes Among Hyperuricemic Men and Women in the Kinmen Study. J Rheumatol. 2004;31(6):1159-65. PubMed PMID: 15170930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different progressions of hyperglycemia and diabetes among hyperuricemic men and women in the kinmen study. AU - Lin,Kuan-Chia, AU - Tsai,Shih-Tzer, AU - Lin,Hsiao-Yi, AU - Chou,Pesus, PY - 2004/6/2/pubmed PY - 2004/9/15/medline PY - 2004/6/2/entrez SP - 1159 EP - 65 JF - The Journal of rheumatology JO - J Rheumatol VL - 31 IS - 6 N2 - OBJECTIVE: A 7-year followup study among hyperuricemic subjects was conducted to investigate the association between longterm hyperuricemia and subsequent hyperglycemia and diabetes mellitus. The possible sex difference was also investigated. METHODS: A total of 641 hyperuricemic subjects aged 30 years and over (391 men, 250 women) screened from the community-based Kinmen Study in 1991-92 (the baseline study) were followed in 1997-98, with 75% followup rate. Demographic, clinical, and biochemical data were collected in both baseline and followup periods. RESULTS: After followup for 7 years, the distribution of plasma glucose concentrations changed moderately among male hyperuricemic subjects, but increased markedly among female subjects. The increase of uric acid levels during the followup period was correlated with subsequent diabetes only among hyperuricemic women. Moreover, a relatively higher incidence of diabetes was found in postmenopausal hyperuricemic women after 7-year followup. CONCLUSION: Although the direct role and causality played by uric acid cannot be confirmed by this study, the findings, as applicable to a Chinese nondiabetic population, show that specific progressions of plasma glucose concentrations were significantly different between male and female hyperuricemic subjects. Hyperuricemia and persistent increase in uric acid levels among postmenopausal women should alert physicians to the possibility of subsequent hyperglycemia and diabetes. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/15170930/Different_progressions_of_hyperglycemia_and_diabetes_among_hyperuricemic_men_and_women_in_the_kinmen_study_ DB - PRIME DP - Unbound Medicine ER -