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Massive intracranial hemorrhage associated with the ingestion of dimethyl sulfoxide.
Vet Hum Toxicol. 2004 Jun; 46(3):138-40.VH

Abstract

Dimethyl sulfoxide (DMSO) has been widely used in the treatment of arthritis and certain inflammatory diseases, and is also considered an alternative remedy for cancer even if not supported by concrete evidence. This report illustrates the first case of a fatal complication following the illicit use of this agent. A 55-y-old man who reportedly ingested 500 mg acetaminophen and approximately 1 ml DMSO solution was brought to the emergency department after experiencing 2 tonic-clonic seizures. He had been diagnosed with lung mesotelioma with brain metastases which caused no neurologic deficit. The ingested DMSO was the first dose within the last 3 mo. Examination revealed right-sided hemiplegia. Unenhanced computed tomography of the head showed 3 hemorrhagic areas with blood-cerebrospinal fluid at the left parietal, occipital and frontal regions accompanied by a midline shift. Despite initial resuscitation, 2 units of fresh frozen plasma and antiedema treatment, the patient experienced cardiac arrest that did not respond to resuscitative measures. DMSO can cause massive intrametastatic hemorrhage, and neurologic deterioration can be profound in patients with metastatic brain lesions.

Authors+Show Affiliations

Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15171490

Citation

Topacoglu, Hakan, et al. "Massive Intracranial Hemorrhage Associated With the Ingestion of Dimethyl Sulfoxide." Veterinary and Human Toxicology, vol. 46, no. 3, 2004, pp. 138-40.
Topacoglu H, Karcioglu O, Ozsarac M, et al. Massive intracranial hemorrhage associated with the ingestion of dimethyl sulfoxide. Vet Hum Toxicol. 2004;46(3):138-40.
Topacoglu, H., Karcioglu, O., Ozsarac, M., Oray, D., Niyazi Ozucelik, D., & Tuncok, Y. (2004). Massive intracranial hemorrhage associated with the ingestion of dimethyl sulfoxide. Veterinary and Human Toxicology, 46(3), 138-40.
Topacoglu H, et al. Massive Intracranial Hemorrhage Associated With the Ingestion of Dimethyl Sulfoxide. Vet Hum Toxicol. 2004;46(3):138-40. PubMed PMID: 15171490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Massive intracranial hemorrhage associated with the ingestion of dimethyl sulfoxide. AU - Topacoglu,Hakan, AU - Karcioglu,Ozgur, AU - Ozsarac,Murat, AU - Oray,Deniz, AU - Niyazi Ozucelik,Dogac, AU - Tuncok,Yesim, PY - 2004/6/3/pubmed PY - 2004/7/9/medline PY - 2004/6/3/entrez SP - 138 EP - 40 JF - Veterinary and human toxicology JO - Vet Hum Toxicol VL - 46 IS - 3 N2 - Dimethyl sulfoxide (DMSO) has been widely used in the treatment of arthritis and certain inflammatory diseases, and is also considered an alternative remedy for cancer even if not supported by concrete evidence. This report illustrates the first case of a fatal complication following the illicit use of this agent. A 55-y-old man who reportedly ingested 500 mg acetaminophen and approximately 1 ml DMSO solution was brought to the emergency department after experiencing 2 tonic-clonic seizures. He had been diagnosed with lung mesotelioma with brain metastases which caused no neurologic deficit. The ingested DMSO was the first dose within the last 3 mo. Examination revealed right-sided hemiplegia. Unenhanced computed tomography of the head showed 3 hemorrhagic areas with blood-cerebrospinal fluid at the left parietal, occipital and frontal regions accompanied by a midline shift. Despite initial resuscitation, 2 units of fresh frozen plasma and antiedema treatment, the patient experienced cardiac arrest that did not respond to resuscitative measures. DMSO can cause massive intrametastatic hemorrhage, and neurologic deterioration can be profound in patients with metastatic brain lesions. SN - 0145-6296 UR - https://www.unboundmedicine.com/medline/citation/15171490/Massive_intracranial_hemorrhage_associated_with_the_ingestion_of_dimethyl_sulfoxide_ L2 - https://www.lens.org/lens/search?q=citation_id:15171490 DB - PRIME DP - Unbound Medicine ER -