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[Comparative study on the clinical features of Alzheimer's disease and vascular dementia].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Apr; 26(2):122-7.ZY

Abstract

OBJECTIVE

To investigate the clinical features of Alzheimer's disease (AD) and vascular dementia (VaD), and to find effective methods for differential diagnosis between the two entities.

METHODS

Totally 112 AD patients and 92 VaD patients were enrolled in this study, consisted of patients from the memory clinics and patients from the community population visited during the epidemiological survey from 1996 to 2000. Diagnosis of dementia, probable AD and probable VaD were made according to international criteria. Results of specific neuroimaging examination were referred to verify the diagnosis and the final diagnosis of each patient was determined from the discussion between clinical experts and radiological professionals. Analysis on clinical and neuroimaging data was performed, aiming at finding differential points between the two dementia-subtypes. A logistic binary multiple regression analysis was performed to pick out those statistically significant clinical features for differential diagnosis at last.

RESULTS

AD and VaD patients have different clinical features in various demented stages, therefore the indexes that differentiate the two dementia subtypes change accordingly. The predominant features of mild AD appear to be deficits of prolonged memory and learning ability, while the major impairment of mild VaD patients is decline of calculating ability. With the progress of dementia, learning ability and attention turn to be the effective indexes for differential diagnosis. In the mild and moderate demented stage, AD patients are inferior to VaD patients in handling finacial affairs and making phone calls, while VaD patients often degenerate in daily activities concerning with both physical ability and intellectual level. Severe VaD patients appears more global degeneration of living ability compared to AD patients. The difference of ADL scores between the two subtypes is significant in moderate to severe demented patients (P < 0.05). Psychological behavior symptoms, such as repeatedly collecting useless things, are the characteristic manifestation to differentiate AD from VaD in all clinical stages.

CONCLUSIONS

The results of our study indicate that substantial differences exist between AD and VaD patients. Such differences can be attributed to the differences of lesion nature and distribution, as well as the underlying pathophysiological procedures of each disease.

Authors+Show Affiliations

Department of Clinical Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. connie1976@vip.sina.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15171546

Citation

Chen, Xia, et al. "[Comparative Study On the Clinical Features of Alzheimer's Disease and Vascular Dementia]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 26, no. 2, 2004, pp. 122-7.
Chen X, Zhang ZX, Huang JB, et al. [Comparative study on the clinical features of Alzheimer's disease and vascular dementia]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(2):122-7.
Chen, X., Zhang, Z. X., Huang, J. B., & Wen, H. B. (2004). [Comparative study on the clinical features of Alzheimer's disease and vascular dementia]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 26(2), 122-7.
Chen X, et al. [Comparative Study On the Clinical Features of Alzheimer's Disease and Vascular Dementia]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(2):122-7. PubMed PMID: 15171546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative study on the clinical features of Alzheimer's disease and vascular dementia]. AU - Chen,Xia, AU - Zhang,Zhen-xin, AU - Huang,Jue-bin, AU - Wen,Hong-bo, PY - 2004/6/3/pubmed PY - 2004/7/23/medline PY - 2004/6/3/entrez SP - 122 EP - 7 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 26 IS - 2 N2 - OBJECTIVE: To investigate the clinical features of Alzheimer's disease (AD) and vascular dementia (VaD), and to find effective methods for differential diagnosis between the two entities. METHODS: Totally 112 AD patients and 92 VaD patients were enrolled in this study, consisted of patients from the memory clinics and patients from the community population visited during the epidemiological survey from 1996 to 2000. Diagnosis of dementia, probable AD and probable VaD were made according to international criteria. Results of specific neuroimaging examination were referred to verify the diagnosis and the final diagnosis of each patient was determined from the discussion between clinical experts and radiological professionals. Analysis on clinical and neuroimaging data was performed, aiming at finding differential points between the two dementia-subtypes. A logistic binary multiple regression analysis was performed to pick out those statistically significant clinical features for differential diagnosis at last. RESULTS: AD and VaD patients have different clinical features in various demented stages, therefore the indexes that differentiate the two dementia subtypes change accordingly. The predominant features of mild AD appear to be deficits of prolonged memory and learning ability, while the major impairment of mild VaD patients is decline of calculating ability. With the progress of dementia, learning ability and attention turn to be the effective indexes for differential diagnosis. In the mild and moderate demented stage, AD patients are inferior to VaD patients in handling finacial affairs and making phone calls, while VaD patients often degenerate in daily activities concerning with both physical ability and intellectual level. Severe VaD patients appears more global degeneration of living ability compared to AD patients. The difference of ADL scores between the two subtypes is significant in moderate to severe demented patients (P < 0.05). Psychological behavior symptoms, such as repeatedly collecting useless things, are the characteristic manifestation to differentiate AD from VaD in all clinical stages. CONCLUSIONS: The results of our study indicate that substantial differences exist between AD and VaD patients. Such differences can be attributed to the differences of lesion nature and distribution, as well as the underlying pathophysiological procedures of each disease. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/15171546/[Comparative_study_on_the_clinical_features_of_Alzheimer's_disease_and_vascular_dementia]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -