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[Advances in molecular biology and clinical study of amyloid precursor protein for Alzheimer's disease].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Apr; 26(2):201-9.ZY

Abstract

Alzheimer's disease (AD) is the most common cause of dementia in elderly population. There are two hallmark pathological lesions: the intracellular neurofibrillary tangles (NFTs) and the extracellular amyloid deposits in the senile plaques (SP). The NFTs are aggregates of hyperphosphorylated microtubule Tau protein. The amyloid deposits in the SP are the beta-amyloid (Abeta) peptides-Abeta40 and Abeta42. The Abeta peptides are derived from the amyloid precursor protein (APP) which is considered very important for the AD pathogenesis. In recent years, studies have focused on understanding the generation of Abeta peptides by the alpha-, beta- and gamma- secretase activity on APP, as cause and progression of both familial and sporadic AD (FAD and SAD). This review covers the trafficking and processing of APP, the amyloid cascade hypothesis in AD pathogenesis, the mutations in the genes encoding APP, PS1 and PS2 of early-onset and late-onset AD. The risk factor apolipoprotein E (ApoE) for AD and therapeutic anti-beta-amyloid vaccination strategies for prevention of AD are also discussed.

Authors+Show Affiliations

Xu BG
Washington University School of Medicine, St.Louis, Mo 63110, USA.
Wu X
No affiliation info available

MeSH

Alzheimer DiseaseAlzheimer VaccinesAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsApolipoproteins EHumansImmunotherapy, ActiveMembrane ProteinsPeptide FragmentsPlaque, AmyloidPresenilin-1Presenilin-2

Pub Type(s)

English Abstract
Journal Article
Review

Language

chi

PubMed ID

15171563

Citation

Xu, Bao-gang, and Xun Wu. "[Advances in Molecular Biology and Clinical Study of Amyloid Precursor Protein for Alzheimer's Disease]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 26, no. 2, 2004, pp. 201-9.
Xu BG, Wu X. [Advances in molecular biology and clinical study of amyloid precursor protein for Alzheimer's disease]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(2):201-9.
Xu, B. G., & Wu, X. (2004). [Advances in molecular biology and clinical study of amyloid precursor protein for Alzheimer's disease]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 26(2), 201-9.
Xu BG, Wu X. [Advances in Molecular Biology and Clinical Study of Amyloid Precursor Protein for Alzheimer's Disease]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004;26(2):201-9. PubMed PMID: 15171563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Advances in molecular biology and clinical study of amyloid precursor protein for Alzheimer's disease]. AU - Xu,Bao-gang, AU - Wu,Xun, PY - 2004/6/3/pubmed PY - 2004/7/23/medline PY - 2004/6/3/entrez SP - 201 EP - 9 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 26 IS - 2 N2 - Alzheimer's disease (AD) is the most common cause of dementia in elderly population. There are two hallmark pathological lesions: the intracellular neurofibrillary tangles (NFTs) and the extracellular amyloid deposits in the senile plaques (SP). The NFTs are aggregates of hyperphosphorylated microtubule Tau protein. The amyloid deposits in the SP are the beta-amyloid (Abeta) peptides-Abeta40 and Abeta42. The Abeta peptides are derived from the amyloid precursor protein (APP) which is considered very important for the AD pathogenesis. In recent years, studies have focused on understanding the generation of Abeta peptides by the alpha-, beta- and gamma- secretase activity on APP, as cause and progression of both familial and sporadic AD (FAD and SAD). This review covers the trafficking and processing of APP, the amyloid cascade hypothesis in AD pathogenesis, the mutations in the genes encoding APP, PS1 and PS2 of early-onset and late-onset AD. The risk factor apolipoprotein E (ApoE) for AD and therapeutic anti-beta-amyloid vaccination strategies for prevention of AD are also discussed. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/15171563/[Advances_in_molecular_biology_and_clinical_study_of_amyloid_precursor_protein_for_Alzheimer's_disease]_ DB - PRIME DP - Unbound Medicine ER -