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[Studies on chemical constituents of Halenia elliptica guided by in vivo absorption and distribution of the constituents].
Yao Xue Xue Bao. 2004 Mar; 39(3):198-203.YX

Abstract

AIM

To investigate the chemical constituents of the Tibetan herbal medicine Halenia elliptica by guidance of in vivo absorption and distribution of the constituents.

METHODS

HPLC with a diode array detector (DAD) and HPLC-MS were used for detecting the constituents of extracts of Halenia elliptica and animal samples. Several kinds of column chromatography were used for the isolation and purification of the main in vivo absorbed and distributed compounds from the extract of Halenia elliptica.

RESULTS

Six main components detected in the extracts of the animal samples were isolated from the ethanolic extract of Halenia elliptica.

CONCLUSION

After rats were treated with different extracts of Halenia elliplica, low polar components xanthone aglycon of Halenia elliptica were clearly observed in the extracts of liver, lipid, blood, hidney, heart and brain tissue of rats, while the polar components xanthone glycosides were detected in very small amounts in the animal samples. The xanthone glycosides can be decomposed into xanthone aglycons during the digestion, absorption and metabolism procedure. Therefore, the in vivo activity of the xanthone glycosides might be exhibited by their decomposed products. It is an accessibly valuable method to investigate chemical components of herbal medicines under the guidance by detecting in vivo absorption and distribution of chemical components of the herbal medicine extract.

Authors+Show Affiliations

Gao J
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Wang SJ
No affiliation info available
Xu RM
No affiliation info available
Yang YC
No affiliation info available
Zhang SR
No affiliation info available
Si YK
No affiliation info available
Shi JG
No affiliation info available

MeSH

AbsorptionAnimalsChromatography, High Pressure LiquidDrugs, Chinese HerbalFemaleGentianaceaeGlycosidesPlants, MedicinalRatsRats, WistarTissue DistributionXanthones

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15171655

Citation

Gao, Jie, et al. "[Studies On Chemical Constituents of Halenia Elliptica Guided By in Vivo Absorption and Distribution of the Constituents]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 39, no. 3, 2004, pp. 198-203.
Gao J, Wang SJ, Xu RM, et al. [Studies on chemical constituents of Halenia elliptica guided by in vivo absorption and distribution of the constituents]. Yao Xue Xue Bao. 2004;39(3):198-203.
Gao, J., Wang, S. J., Xu, R. M., Yang, Y. C., Zhang, S. R., Si, Y. K., & Shi, J. G. (2004). [Studies on chemical constituents of Halenia elliptica guided by in vivo absorption and distribution of the constituents]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 39(3), 198-203.
Gao J, et al. [Studies On Chemical Constituents of Halenia Elliptica Guided By in Vivo Absorption and Distribution of the Constituents]. Yao Xue Xue Bao. 2004;39(3):198-203. PubMed PMID: 15171655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies on chemical constituents of Halenia elliptica guided by in vivo absorption and distribution of the constituents]. AU - Gao,Jie, AU - Wang,Su-juan, AU - Xu,Rui-ming, AU - Yang,Yong-chun, AU - Zhang,Shou-ren, AU - Si,Yi-kang, AU - Shi,Jian-gong, PY - 2004/6/3/pubmed PY - 2004/8/18/medline PY - 2004/6/3/entrez SP - 198 EP - 203 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 39 IS - 3 N2 - AIM: To investigate the chemical constituents of the Tibetan herbal medicine Halenia elliptica by guidance of in vivo absorption and distribution of the constituents. METHODS: HPLC with a diode array detector (DAD) and HPLC-MS were used for detecting the constituents of extracts of Halenia elliptica and animal samples. Several kinds of column chromatography were used for the isolation and purification of the main in vivo absorbed and distributed compounds from the extract of Halenia elliptica. RESULTS: Six main components detected in the extracts of the animal samples were isolated from the ethanolic extract of Halenia elliptica. CONCLUSION: After rats were treated with different extracts of Halenia elliplica, low polar components xanthone aglycon of Halenia elliptica were clearly observed in the extracts of liver, lipid, blood, hidney, heart and brain tissue of rats, while the polar components xanthone glycosides were detected in very small amounts in the animal samples. The xanthone glycosides can be decomposed into xanthone aglycons during the digestion, absorption and metabolism procedure. Therefore, the in vivo activity of the xanthone glycosides might be exhibited by their decomposed products. It is an accessibly valuable method to investigate chemical components of herbal medicines under the guidance by detecting in vivo absorption and distribution of chemical components of the herbal medicine extract. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/15171655/[Studies_on_chemical_constituents_of_Halenia_elliptica_guided_by_in_vivo_absorption_and_distribution_of_the_constituents]_ DB - PRIME DP - Unbound Medicine ER -