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High-strength tretinoin for rapid retinization of photoaged facial skin.

Abstract

BACKGROUND

Emollient creams of 0.02% and 0.05% tretinoin are currently used for improving the appearance of photoaged skin. At these concentrations, using this vehicle, the clinical results take many months.

OBJECTIVE

The objective was to formulate and test a higher strength tretinoin that enhances penetration of the active molecule through the stratum corneum so that the clinical result is achieved after 1 month of treatment.

METHODS

Thirty-two female subjects underwent treatment with 0.25% tretinoin solution applied nightly for 1 month. Subjects were evaluated clinically at baseline and 1, 2, and 4 weeks. Clinical grading was performed by comparing digital photographs before and after treatment.

RESULTS

Almost all subjects improved on all measures of clinical grading (fine lines, mottled pigmentation, surface texture/roughness) by the end of the study.

CONCLUSION

Tretinoin solution at a concentration of 0.25% is an effective and tolerable treatment for photodamaged facial skin and greatly shortens the time required for clinical response.

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  • Authors+Show Affiliations

    ,

    SKIN, Inc., Conshohocken, Pennsylvania, USA. skininc1@aol.com

    Source

    MeSH

    Administration, Cutaneous
    Adult
    Drug Administration Schedule
    Facial Dermatoses
    Female
    Humans
    Keratolytic Agents
    Middle Aged
    Skin Aging
    Treatment Outcome
    Tretinoin

    Pub Type(s)

    Clinical Trial
    Journal Article

    Language

    eng

    PubMed ID

    15171763

    Citation

    Kligman, Douglas E., and Zoe Diana Draelos. "High-strength Tretinoin for Rapid Retinization of Photoaged Facial Skin." Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], vol. 30, no. 6, 2004, pp. 864-6.
    Kligman DE, Draelos ZD. High-strength tretinoin for rapid retinization of photoaged facial skin. Dermatol Surg. 2004;30(6):864-6.
    Kligman, D. E., & Draelos, Z. D. (2004). High-strength tretinoin for rapid retinization of photoaged facial skin. Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], 30(6), pp. 864-6.
    Kligman DE, Draelos ZD. High-strength Tretinoin for Rapid Retinization of Photoaged Facial Skin. Dermatol Surg. 2004;30(6):864-6. PubMed PMID: 15171763.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High-strength tretinoin for rapid retinization of photoaged facial skin. AU - Kligman,Douglas E, AU - Draelos,Zoe Diana, PY - 2004/6/3/pubmed PY - 2004/7/15/medline PY - 2004/6/3/entrez SP - 864 EP - 6 JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JO - Dermatol Surg VL - 30 IS - 6 N2 - BACKGROUND: Emollient creams of 0.02% and 0.05% tretinoin are currently used for improving the appearance of photoaged skin. At these concentrations, using this vehicle, the clinical results take many months. OBJECTIVE: The objective was to formulate and test a higher strength tretinoin that enhances penetration of the active molecule through the stratum corneum so that the clinical result is achieved after 1 month of treatment. METHODS: Thirty-two female subjects underwent treatment with 0.25% tretinoin solution applied nightly for 1 month. Subjects were evaluated clinically at baseline and 1, 2, and 4 weeks. Clinical grading was performed by comparing digital photographs before and after treatment. RESULTS: Almost all subjects improved on all measures of clinical grading (fine lines, mottled pigmentation, surface texture/roughness) by the end of the study. CONCLUSION: Tretinoin solution at a concentration of 0.25% is an effective and tolerable treatment for photodamaged facial skin and greatly shortens the time required for clinical response. SN - 1076-0512 UR - https://www.unboundmedicine.com/medline/citation/15171763/High_strength_tretinoin_for_rapid_retinization_of_photoaged_facial_skin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1076-0512&date=2004&volume=30&issue=6&spage=864 DB - PRIME DP - Unbound Medicine ER -