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High-strength tretinoin for rapid retinization of photoaged facial skin.
Dermatol Surg. 2004 Jun; 30(6):864-6.DS

Abstract

BACKGROUND

Emollient creams of 0.02% and 0.05% tretinoin are currently used for improving the appearance of photoaged skin. At these concentrations, using this vehicle, the clinical results take many months.

OBJECTIVE

The objective was to formulate and test a higher strength tretinoin that enhances penetration of the active molecule through the stratum corneum so that the clinical result is achieved after 1 month of treatment.

METHODS

Thirty-two female subjects underwent treatment with 0.25% tretinoin solution applied nightly for 1 month. Subjects were evaluated clinically at baseline and 1, 2, and 4 weeks. Clinical grading was performed by comparing digital photographs before and after treatment.

RESULTS

Almost all subjects improved on all measures of clinical grading (fine lines, mottled pigmentation, surface texture/roughness) by the end of the study.

CONCLUSION

Tretinoin solution at a concentration of 0.25% is an effective and tolerable treatment for photodamaged facial skin and greatly shortens the time required for clinical response.

Authors+Show Affiliations

SKIN, Inc., Conshohocken, Pennsylvania, USA. skininc1@aol.comNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15171763

Citation

Kligman, Douglas E., and Zoe Diana Draelos. "High-strength Tretinoin for Rapid Retinization of Photoaged Facial Skin." Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], vol. 30, no. 6, 2004, pp. 864-6.
Kligman DE, Draelos ZD. High-strength tretinoin for rapid retinization of photoaged facial skin. Dermatol Surg. 2004;30(6):864-6.
Kligman, D. E., & Draelos, Z. D. (2004). High-strength tretinoin for rapid retinization of photoaged facial skin. Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], 30(6), 864-6.
Kligman DE, Draelos ZD. High-strength Tretinoin for Rapid Retinization of Photoaged Facial Skin. Dermatol Surg. 2004;30(6):864-6. PubMed PMID: 15171763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-strength tretinoin for rapid retinization of photoaged facial skin. AU - Kligman,Douglas E, AU - Draelos,Zoe Diana, PY - 2004/6/3/pubmed PY - 2004/7/15/medline PY - 2004/6/3/entrez SP - 864 EP - 6 JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JO - Dermatol Surg VL - 30 IS - 6 N2 - BACKGROUND: Emollient creams of 0.02% and 0.05% tretinoin are currently used for improving the appearance of photoaged skin. At these concentrations, using this vehicle, the clinical results take many months. OBJECTIVE: The objective was to formulate and test a higher strength tretinoin that enhances penetration of the active molecule through the stratum corneum so that the clinical result is achieved after 1 month of treatment. METHODS: Thirty-two female subjects underwent treatment with 0.25% tretinoin solution applied nightly for 1 month. Subjects were evaluated clinically at baseline and 1, 2, and 4 weeks. Clinical grading was performed by comparing digital photographs before and after treatment. RESULTS: Almost all subjects improved on all measures of clinical grading (fine lines, mottled pigmentation, surface texture/roughness) by the end of the study. CONCLUSION: Tretinoin solution at a concentration of 0.25% is an effective and tolerable treatment for photodamaged facial skin and greatly shortens the time required for clinical response. SN - 1076-0512 UR - https://www.unboundmedicine.com/medline/citation/15171763/High_strength_tretinoin_for_rapid_retinization_of_photoaged_facial_skin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1076-0512&date=2004&volume=30&issue=6&spage=864 DB - PRIME DP - Unbound Medicine ER -