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Amelioration of ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by coumarin (1,2-benzopyrone) in Wistar rats.
Cancer Lett. 2004 Jul 08; 210(1):17-26.CL

Abstract

In this study, we report the modulatory effect of coumarin (1,2-benzopyrone) on Ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response in rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H2O2) generation with reduction in antioxidant enzymes and renal glutathione content. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [3H] incorporation into renal DNA. Prophylactic treatment of rats with coumarin (10 and 20 mg/kg body weight) resulted in significant recovery of antioxidant enzymes (P < 0.001) and renal glutathione content (P < 0.01). There was also significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H2O2 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001) Thus, our results show that coumarin is a potent chemopreventive agent and suppresses Fe-NTA induced nephrotoxicity in Wistar rats.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15172116

Citation

Khan, Naghma, et al. "Amelioration of Ferric Nitrilotriacetate (Fe-NTA) Induced Renal Oxidative Stress and Tumor Promotion Response By Coumarin (1,2-benzopyrone) in Wistar Rats." Cancer Letters, vol. 210, no. 1, 2004, pp. 17-26.
Khan N, Sharma S, Sultana S. Amelioration of ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by coumarin (1,2-benzopyrone) in Wistar rats. Cancer Lett. 2004;210(1):17-26.
Khan, N., Sharma, S., & Sultana, S. (2004). Amelioration of ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by coumarin (1,2-benzopyrone) in Wistar rats. Cancer Letters, 210(1), 17-26.
Khan N, Sharma S, Sultana S. Amelioration of Ferric Nitrilotriacetate (Fe-NTA) Induced Renal Oxidative Stress and Tumor Promotion Response By Coumarin (1,2-benzopyrone) in Wistar Rats. Cancer Lett. 2004 Jul 8;210(1):17-26. PubMed PMID: 15172116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amelioration of ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by coumarin (1,2-benzopyrone) in Wistar rats. AU - Khan,Naghma, AU - Sharma,Sonia, AU - Sultana,Sarwat, PY - 2003/09/30/received PY - 2004/01/14/revised PY - 2004/01/15/accepted PY - 2004/6/3/pubmed PY - 2004/8/4/medline PY - 2004/6/3/entrez SP - 17 EP - 26 JF - Cancer letters JO - Cancer Lett VL - 210 IS - 1 N2 - In this study, we report the modulatory effect of coumarin (1,2-benzopyrone) on Ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response in rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H2O2) generation with reduction in antioxidant enzymes and renal glutathione content. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [3H] incorporation into renal DNA. Prophylactic treatment of rats with coumarin (10 and 20 mg/kg body weight) resulted in significant recovery of antioxidant enzymes (P < 0.001) and renal glutathione content (P < 0.01). There was also significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H2O2 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001) Thus, our results show that coumarin is a potent chemopreventive agent and suppresses Fe-NTA induced nephrotoxicity in Wistar rats. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/15172116/Amelioration_of_ferric_nitrilotriacetate__Fe_NTA__induced_renal_oxidative_stress_and_tumor_promotion_response_by_coumarin__12_benzopyrone__in_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304383504000564 DB - PRIME DP - Unbound Medicine ER -