Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal.J Am Coll Cardiol. 2004 Jun 02; 43(11):2142-6.JACC
Abstract
The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.
MeSH
Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
15172426
Citation
O'Keefe, James H., et al. "Optimal Low-density Lipoprotein Is 50 to 70 Mg/dl: Lower Is Better and Physiologically Normal." Journal of the American College of Cardiology, vol. 43, no. 11, 2004, pp. 2142-6.
O'Keefe JH, Cordain L, Harris WH, et al. Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. J Am Coll Cardiol. 2004;43(11):2142-6.
O'Keefe, J. H., Cordain, L., Harris, W. H., Moe, R. M., & Vogel, R. (2004). Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. Journal of the American College of Cardiology, 43(11), 2142-6.
O'Keefe JH, et al. Optimal Low-density Lipoprotein Is 50 to 70 Mg/dl: Lower Is Better and Physiologically Normal. J Am Coll Cardiol. 2004 Jun 2;43(11):2142-6. PubMed PMID: 15172426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal.
AU - O'Keefe,James H,Jr
AU - Cordain,Loren,
AU - Harris,William H,
AU - Moe,Richard M,
AU - Vogel,Robert,
PY - 2004/03/14/received
PY - 2004/03/15/accepted
PY - 2004/6/3/pubmed
PY - 2004/6/18/medline
PY - 2004/6/3/entrez
SP - 2142
EP - 6
JF - Journal of the American College of Cardiology
JO - J Am Coll Cardiol
VL - 43
IS - 11
N2 - The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.
SN - 0735-1097
UR - https://www.unboundmedicine.com/medline/citation/15172426/full_citation
DB - PRIME
DP - Unbound Medicine
ER -
