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Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal.

Abstract

The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.

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  • Authors+Show Affiliations

    ,

    Mid America Heart Institute, Cardiovascular Consultants, Kansas City, Missouri 64111, USA. jhokeefe@cc-pc.com

    , , ,

    Source

    MeSH

    Animals
    Anticholesteremic Agents
    Cholesterol
    Cholesterol, LDL
    Coronary Artery Disease
    Humans
    Practice Guidelines as Topic
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    15172426

    Citation

    O'Keefe, James H., et al. "Optimal Low-density Lipoprotein Is 50 to 70 Mg/dl: Lower Is Better and Physiologically Normal." Journal of the American College of Cardiology, vol. 43, no. 11, 2004, pp. 2142-6.
    O'Keefe JH, Cordain L, Harris WH, et al. Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. J Am Coll Cardiol. 2004;43(11):2142-6.
    O'Keefe, J. H., Cordain, L., Harris, W. H., Moe, R. M., & Vogel, R. (2004). Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. Journal of the American College of Cardiology, 43(11), pp. 2142-6.
    O'Keefe JH, et al. Optimal Low-density Lipoprotein Is 50 to 70 Mg/dl: Lower Is Better and Physiologically Normal. J Am Coll Cardiol. 2004 Jun 2;43(11):2142-6. PubMed PMID: 15172426.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. AU - O'Keefe,James H,Jr AU - Cordain,Loren, AU - Harris,William H, AU - Moe,Richard M, AU - Vogel,Robert, PY - 2004/03/14/received PY - 2004/03/15/accepted PY - 2004/6/3/pubmed PY - 2004/6/18/medline PY - 2004/6/3/entrez SP - 2142 EP - 6 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 43 IS - 11 N2 - The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDL is lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/15172426/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735109704007168 DB - PRIME DP - Unbound Medicine ER -