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In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide.

Abstract

BACKGROUND

Depression is accompanied by a depletion of n-3 poly-unsaturated fatty acids (PUFAs). There is also a negative correlation between suicide and fish-oil intake (rich in n-3 PUFAs) across different countries. Both depression and suicide show a seasonal variation and are related to disorders in the serotonergic system.

AIMS

The present study was carried out to determine if there is a seasonal variation in the PUFA fractions in serum phospholipids and whether there are significant relationships between lowered n-3 PUFA status and the seasonal variation in the number of suicide deaths and serotonergic markers of suicide.

METHODS

We took monthly blood samples during 1 calendar year from 23 healthy volunteers and analyzed the PUFA composition in serum phospholipids and related those data to the annual variation in the mean weekly number of suicides for Belgium and the Bmax [3H]-paroxetine binding to platelets in the same 23 subjects.

RESULTS

Significant annual rhythms were detected in the long-chain PUFAs only, i.e. arachidonic acid (C20: 4n-6; AA), eicosapentaenoic acid (C20: 5n-3; EPA), and docosahexaenoic acid (C22: 6n-3; DHA). There was a significant correlation between the changes over the last 2 weeks in AA and EPA and the mean weekly number of violent, but not nonviolent, suicide deaths in Belgium. There was a significant correlation between the PUFAs, AA and DHA, and the Bmax [3H]-paroxetine binding to platelets.

CONCLUSIONS

Our results show that there is a true seasonality in long-chain PUFAs, such as AA, EPA and DHA. The results suggest that the seasonality in PUFAs may be related to the incidence of violent suicide and the expression of the serotonin transporter complex.

Authors+Show Affiliations

Department of Internal Medicine, Division of Nutrition, Ghent University Hospital, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15172679

Citation

De Vriese, S R., et al. "In Humans, the Seasonal Variation in Poly-unsaturated Fatty Acids Is Related to the Seasonal Variation in Violent Suicide and Serotonergic Markers of Violent Suicide." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 71, no. 1, 2004, pp. 13-8.
De Vriese SR, Christophe AB, Maes M. In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide. Prostaglandins Leukot Essent Fatty Acids. 2004;71(1):13-8.
De Vriese, S. R., Christophe, A. B., & Maes, M. (2004). In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 71(1), 13-8.
De Vriese SR, Christophe AB, Maes M. In Humans, the Seasonal Variation in Poly-unsaturated Fatty Acids Is Related to the Seasonal Variation in Violent Suicide and Serotonergic Markers of Violent Suicide. Prostaglandins Leukot Essent Fatty Acids. 2004;71(1):13-8. PubMed PMID: 15172679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide. AU - De Vriese,S R, AU - Christophe,A B, AU - Maes,M, PY - 2003/12/01/received PY - 2003/12/03/accepted PY - 2004/6/3/pubmed PY - 2005/1/14/medline PY - 2004/6/3/entrez SP - 13 EP - 8 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 71 IS - 1 N2 - BACKGROUND: Depression is accompanied by a depletion of n-3 poly-unsaturated fatty acids (PUFAs). There is also a negative correlation between suicide and fish-oil intake (rich in n-3 PUFAs) across different countries. Both depression and suicide show a seasonal variation and are related to disorders in the serotonergic system. AIMS: The present study was carried out to determine if there is a seasonal variation in the PUFA fractions in serum phospholipids and whether there are significant relationships between lowered n-3 PUFA status and the seasonal variation in the number of suicide deaths and serotonergic markers of suicide. METHODS: We took monthly blood samples during 1 calendar year from 23 healthy volunteers and analyzed the PUFA composition in serum phospholipids and related those data to the annual variation in the mean weekly number of suicides for Belgium and the Bmax [3H]-paroxetine binding to platelets in the same 23 subjects. RESULTS: Significant annual rhythms were detected in the long-chain PUFAs only, i.e. arachidonic acid (C20: 4n-6; AA), eicosapentaenoic acid (C20: 5n-3; EPA), and docosahexaenoic acid (C22: 6n-3; DHA). There was a significant correlation between the changes over the last 2 weeks in AA and EPA and the mean weekly number of violent, but not nonviolent, suicide deaths in Belgium. There was a significant correlation between the PUFAs, AA and DHA, and the Bmax [3H]-paroxetine binding to platelets. CONCLUSIONS: Our results show that there is a true seasonality in long-chain PUFAs, such as AA, EPA and DHA. The results suggest that the seasonality in PUFAs may be related to the incidence of violent suicide and the expression of the serotonin transporter complex. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/15172679/In_humans_the_seasonal_variation_in_poly_unsaturated_fatty_acids_is_related_to_the_seasonal_variation_in_violent_suicide_and_serotonergic_markers_of_violent_suicide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952327803002564 DB - PRIME DP - Unbound Medicine ER -