Tags

Type your tag names separated by a space and hit enter

Parent-of-origin effect in multiple sclerosis: observations in half-siblings.

Abstract

Multiple sclerosis is a complex trait in which occurrence rates in offspring are 20-50-fold greater than in the general population. Parent-of-origin effects have been difficult to screen for, since most cases are sporadic. We have compared recurrence risks in half-siblings with respect to their parent in common. Of the 1567 index cases with half-siblings in multiple sclerosis clinics across Canada, we recorded 3436 half-siblings and 2706 full-siblings. Age-adjusted full-sibling risk was 3.11%. By contrast, half-sibling risk in the same families was significantly lower at 1.89% (chi2 test, p=0.006), but higher than expected if familial risk was simply polygenic. For maternal half-siblings, the risk was 2.35% (34 affected siblings of 1859), and 1.31% for paternal half-siblings (15 of 1577), (p=0.048). The difference in risk suggests a maternal parent-of-origin effect in multiple sclerosis susceptibility.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. george.ebers@clinical-neurology.oxford.ac.uk

    , , , ,

    Source

    Lancet (London, England) 363:9423 2004 May 29 pg 1773-4

    MeSH

    Female
    Genetic Predisposition to Disease
    Humans
    Male
    Mothers
    Multiple Sclerosis
    Parents
    Siblings

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15172777

    Citation

    Ebers, G C., et al. "Parent-of-origin Effect in Multiple Sclerosis: Observations in Half-siblings." Lancet (London, England), vol. 363, no. 9423, 2004, pp. 1773-4.
    Ebers GC, Sadovnick AD, Dyment DA, et al. Parent-of-origin effect in multiple sclerosis: observations in half-siblings. Lancet. 2004;363(9423):1773-4.
    Ebers, G. C., Sadovnick, A. D., Dyment, D. A., Yee, I. M., Willer, C. J., & Risch, N. (2004). Parent-of-origin effect in multiple sclerosis: observations in half-siblings. Lancet (London, England), 363(9423), pp. 1773-4.
    Ebers GC, et al. Parent-of-origin Effect in Multiple Sclerosis: Observations in Half-siblings. Lancet. 2004 May 29;363(9423):1773-4. PubMed PMID: 15172777.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Parent-of-origin effect in multiple sclerosis: observations in half-siblings. AU - Ebers,G C, AU - Sadovnick,A D, AU - Dyment,D A, AU - Yee,I M L, AU - Willer,C J, AU - Risch,Neil, PY - 2004/6/3/pubmed PY - 2004/6/16/medline PY - 2004/6/3/entrez SP - 1773 EP - 4 JF - Lancet (London, England) JO - Lancet VL - 363 IS - 9423 N2 - Multiple sclerosis is a complex trait in which occurrence rates in offspring are 20-50-fold greater than in the general population. Parent-of-origin effects have been difficult to screen for, since most cases are sporadic. We have compared recurrence risks in half-siblings with respect to their parent in common. Of the 1567 index cases with half-siblings in multiple sclerosis clinics across Canada, we recorded 3436 half-siblings and 2706 full-siblings. Age-adjusted full-sibling risk was 3.11%. By contrast, half-sibling risk in the same families was significantly lower at 1.89% (chi2 test, p=0.006), but higher than expected if familial risk was simply polygenic. For maternal half-siblings, the risk was 2.35% (34 affected siblings of 1859), and 1.31% for paternal half-siblings (15 of 1577), (p=0.048). The difference in risk suggests a maternal parent-of-origin effect in multiple sclerosis susceptibility. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/15172777/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140673604163046 DB - PRIME DP - Unbound Medicine ER -