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Marijuana use and risk of oral squamous cell carcinoma.
Cancer Res. 2004 Jun 01; 64(11):4049-54.CR

Abstract

Previous laboratory investigations, case reports, and a hospital-based case-control study have suggested that marijuana use may be a risk factor for squamous cell head and neck cancer. We conducted a population-based case-control study to determine whether marijuana use is associated with the development of oral squamous cell carcinoma (OSCC). Case subjects (n = 407) were 18-65-year-old residents of three counties in western Washington State who were newly diagnosed with OSCC from 1985 through 1995. Control subjects (n = 615), who were similar to the cases with respect to age and sex, were selected from the general population using random-digit telephone dialing. Lifetime histories of marijuana use and exposure to known OSCC risk factors were ascertained using a structured questionnaire. Information on genetic polymorphisms in glutathione S-transferase enzymes was obtained from assays on participant DNA. Odds ratios for associations with features of marijuana use were adjusted for sex, education, birth year, alcohol consumption, and cigarette smoking. A similar proportion of case subjects (25.6%) and control subjects (24.4%) reported ever use of marijuana (adjusted odds ratio, 0.9; 95% confidence interval, 0.6-1.3). There were no trends in risk observed with increasing duration or average frequency of use or time since first or last use. No subgroup defined by known or suspected OSCC risk factors (age, cigarette smoking, alcohol consumption, and genetic polymorphisms) showed an increased risk. Marijuana use was not associated with OSCC risk in this large, population-based study.

Authors+Show Affiliations

Department of Community Health, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15173020

Citation

Rosenblatt, Karin A., et al. "Marijuana Use and Risk of Oral Squamous Cell Carcinoma." Cancer Research, vol. 64, no. 11, 2004, pp. 4049-54.
Rosenblatt KA, Daling JR, Chen C, et al. Marijuana use and risk of oral squamous cell carcinoma. Cancer Res. 2004;64(11):4049-54.
Rosenblatt, K. A., Daling, J. R., Chen, C., Sherman, K. J., & Schwartz, S. M. (2004). Marijuana use and risk of oral squamous cell carcinoma. Cancer Research, 64(11), 4049-54.
Rosenblatt KA, et al. Marijuana Use and Risk of Oral Squamous Cell Carcinoma. Cancer Res. 2004 Jun 1;64(11):4049-54. PubMed PMID: 15173020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marijuana use and risk of oral squamous cell carcinoma. AU - Rosenblatt,Karin A, AU - Daling,Janet R, AU - Chen,Chu, AU - Sherman,Karen J, AU - Schwartz,Stephen M, PY - 2004/6/3/pubmed PY - 2004/7/28/medline PY - 2004/6/3/entrez SP - 4049 EP - 54 JF - Cancer research JO - Cancer Res. VL - 64 IS - 11 N2 - Previous laboratory investigations, case reports, and a hospital-based case-control study have suggested that marijuana use may be a risk factor for squamous cell head and neck cancer. We conducted a population-based case-control study to determine whether marijuana use is associated with the development of oral squamous cell carcinoma (OSCC). Case subjects (n = 407) were 18-65-year-old residents of three counties in western Washington State who were newly diagnosed with OSCC from 1985 through 1995. Control subjects (n = 615), who were similar to the cases with respect to age and sex, were selected from the general population using random-digit telephone dialing. Lifetime histories of marijuana use and exposure to known OSCC risk factors were ascertained using a structured questionnaire. Information on genetic polymorphisms in glutathione S-transferase enzymes was obtained from assays on participant DNA. Odds ratios for associations with features of marijuana use were adjusted for sex, education, birth year, alcohol consumption, and cigarette smoking. A similar proportion of case subjects (25.6%) and control subjects (24.4%) reported ever use of marijuana (adjusted odds ratio, 0.9; 95% confidence interval, 0.6-1.3). There were no trends in risk observed with increasing duration or average frequency of use or time since first or last use. No subgroup defined by known or suspected OSCC risk factors (age, cigarette smoking, alcohol consumption, and genetic polymorphisms) showed an increased risk. Marijuana use was not associated with OSCC risk in this large, population-based study. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/15173020/Marijuana_use_and_risk_of_oral_squamous_cell_carcinoma_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15173020 DB - PRIME DP - Unbound Medicine ER -