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Optimal timing of cardiac transplantation after ventricular assist device implantation.
J Thorac Cardiovasc Surg. 2004 Jun; 127(6):1789-99.JT

Abstract

OBJECTIVE

We sought to determine the influence of the interval from ventricular assist device implantation to cardiac transplantation on end-organ function and posttransplantation survival.

METHODS

United Network for Organ Sharing data on 2692 heart transplantations performed in adult patients in the United States between October 1999 and March 2001 were reviewed.

RESULTS

Seventeen percent (466) of adult heart transplant recipients were bridged to transplantation with a ventricular assist device. Almost half of patients with ventricular assist devices undergoing transplantation were upgraded to status 1A as a result of ventricular assist device-related complications occurring more than 30 days after ventricular assist device implantation. Creatinine and total bilirubin levels were less in patients undergoing transplantation after 2 to 4 weeks of mechanical support. One-year survival was higher in the nonventricular assist device than in the ventricular assist device group (85.7% vs 79.7%, P =.0004). Within the ventricular assist device group, survival was lower for patients undergoing transplantation within 2 weeks of ventricular assist device implantation compared with those undergoing transplantation later (74.2% vs 84.2 %, P =.03). One-year survival among patients supported with a ventricular assist device for more than 30 days without complications was 91.4%. Multivariate analysis demonstrated a significant independent effect of the time interval from ventricular assist device implantation to transplantation on posttransplantation mortality and suggested that a period of lowest risk might exist between 1 and 3 months after implantation.

CONCLUSIONS

Survival after cardiac transplantation is influenced by the time interval from ventricular assist device insertion to transplantation. Survival is significantly lower when performed within 2 to 4 weeks of ventricular assist device implantation.

Authors+Show Affiliations

Division of Cardiac Surgery, The University of Maryland Medical Center, Baltimore, 21201, USA. jgammie@smail.umaryland.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15173738

Citation

Gammie, James S., et al. "Optimal Timing of Cardiac Transplantation After Ventricular Assist Device Implantation." The Journal of Thoracic and Cardiovascular Surgery, vol. 127, no. 6, 2004, pp. 1789-99.
Gammie JS, Edwards LB, Griffith BP, et al. Optimal timing of cardiac transplantation after ventricular assist device implantation. J Thorac Cardiovasc Surg. 2004;127(6):1789-99.
Gammie, J. S., Edwards, L. B., Griffith, B. P., Pierson, R. N., & Tsao, L. (2004). Optimal timing of cardiac transplantation after ventricular assist device implantation. The Journal of Thoracic and Cardiovascular Surgery, 127(6), 1789-99.
Gammie JS, et al. Optimal Timing of Cardiac Transplantation After Ventricular Assist Device Implantation. J Thorac Cardiovasc Surg. 2004;127(6):1789-99. PubMed PMID: 15173738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimal timing of cardiac transplantation after ventricular assist device implantation. AU - Gammie,James S, AU - Edwards,Leah B, AU - Griffith,Bartley P, AU - Pierson,Richard N,3rd AU - Tsao,Lana, PY - 2004/6/3/pubmed PY - 2004/7/14/medline PY - 2004/6/3/entrez SP - 1789 EP - 99 JF - The Journal of thoracic and cardiovascular surgery JO - J Thorac Cardiovasc Surg VL - 127 IS - 6 N2 - OBJECTIVE: We sought to determine the influence of the interval from ventricular assist device implantation to cardiac transplantation on end-organ function and posttransplantation survival. METHODS: United Network for Organ Sharing data on 2692 heart transplantations performed in adult patients in the United States between October 1999 and March 2001 were reviewed. RESULTS: Seventeen percent (466) of adult heart transplant recipients were bridged to transplantation with a ventricular assist device. Almost half of patients with ventricular assist devices undergoing transplantation were upgraded to status 1A as a result of ventricular assist device-related complications occurring more than 30 days after ventricular assist device implantation. Creatinine and total bilirubin levels were less in patients undergoing transplantation after 2 to 4 weeks of mechanical support. One-year survival was higher in the nonventricular assist device than in the ventricular assist device group (85.7% vs 79.7%, P =.0004). Within the ventricular assist device group, survival was lower for patients undergoing transplantation within 2 weeks of ventricular assist device implantation compared with those undergoing transplantation later (74.2% vs 84.2 %, P =.03). One-year survival among patients supported with a ventricular assist device for more than 30 days without complications was 91.4%. Multivariate analysis demonstrated a significant independent effect of the time interval from ventricular assist device implantation to transplantation on posttransplantation mortality and suggested that a period of lowest risk might exist between 1 and 3 months after implantation. CONCLUSIONS: Survival after cardiac transplantation is influenced by the time interval from ventricular assist device insertion to transplantation. Survival is significantly lower when performed within 2 to 4 weeks of ventricular assist device implantation. SN - 0022-5223 UR - https://www.unboundmedicine.com/medline/citation/15173738/Optimal_timing_of_cardiac_transplantation_after_ventricular_assist_device_implantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022522304000091 DB - PRIME DP - Unbound Medicine ER -