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D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement.
Behav Neurosci. 2004 Jun; 118(3):505-13.BN

Abstract

Several recent studies have reported that D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist, facilitates extinction of learned fear in rats. Other studies have shown that representation of the unconditioned stimulus (US) can reinstate learned fear after extinction. This study examined whether this reinstatement effect occurs in Sprague-Dawley rats given DCS at the time of extinction. Results showed that saline-treated rats exhibited the reinstatement effect but DCS-treated rats did not (Experiments 1 and 2). This lack of reinstatement in DCS-treated rats was not due to residual effects of DCS on either US or context processing (Experiment 3). Overall, these results (a) raise questions about the mechanisms underlying DCS facilitation of extinction and (b) suggest that DCS might have substantial practical benefit.

Authors+Show Affiliations

Ledgerwood L
School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia. lledgerwood@psy.unsw.edu.au
Richardson R
No affiliation info available
Cranney J
No affiliation info available

MeSH

Analysis of VarianceAnimalsAntimetabolitesBehavior, AnimalConditioning, PsychologicalCycloserineDose-Response Relationship, DrugElectroshockExtinction, PsychologicalFearMaleRatsRats, Sprague-DawleyReflex, Startle

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15174928

Citation

Ledgerwood, Lana, et al. "D-cycloserine and the Facilitation of Extinction of Conditioned Fear: Consequences for Reinstatement." Behavioral Neuroscience, vol. 118, no. 3, 2004, pp. 505-13.
Ledgerwood L, Richardson R, Cranney J. D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement. Behav Neurosci. 2004;118(3):505-13.
Ledgerwood, L., Richardson, R., & Cranney, J. (2004). D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement. Behavioral Neuroscience, 118(3), 505-13.
Ledgerwood L, Richardson R, Cranney J. D-cycloserine and the Facilitation of Extinction of Conditioned Fear: Consequences for Reinstatement. Behav Neurosci. 2004;118(3):505-13. PubMed PMID: 15174928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement. AU - Ledgerwood,Lana, AU - Richardson,Rick, AU - Cranney,Jacquelyn, PY - 2004/6/4/pubmed PY - 2004/7/20/medline PY - 2004/6/4/entrez SP - 505 EP - 13 JF - Behavioral neuroscience JO - Behav Neurosci VL - 118 IS - 3 N2 - Several recent studies have reported that D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist, facilitates extinction of learned fear in rats. Other studies have shown that representation of the unconditioned stimulus (US) can reinstate learned fear after extinction. This study examined whether this reinstatement effect occurs in Sprague-Dawley rats given DCS at the time of extinction. Results showed that saline-treated rats exhibited the reinstatement effect but DCS-treated rats did not (Experiments 1 and 2). This lack of reinstatement in DCS-treated rats was not due to residual effects of DCS on either US or context processing (Experiment 3). Overall, these results (a) raise questions about the mechanisms underlying DCS facilitation of extinction and (b) suggest that DCS might have substantial practical benefit. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/15174928/D_cycloserine_and_the_facilitation_of_extinction_of_conditioned_fear:_consequences_for_reinstatement_ DB - PRIME DP - Unbound Medicine ER -