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Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis.
BMJ. 2004 Jun 12; 328(7453):1407.BMJ

Abstract

OBJECTIVE

To compare the safety and clinical outcomes of enteral and parenteral nutrition in patients with acute pancreatitis.

DATA SOURCES

Medline, Embase, Cochrane controlled trials register, and citation review of relevant primary and review articles.

STUDY SELECTION

Randomised controlled studies that compared enteral nutrition with parenteral nutrition in patients with acute pancreatitis. From 117 articles screened, six were identified as randomised controlled trials and were included for data extraction.

DATA EXTRACTION

Six studies with 263 participants were analysed. Descriptive and outcome data were extracted. Main outcome measures were infections, complications other than infections, operative interventions, length of hospital stay, and mortality. The meta-analysis was performed with the random effects model.

DATA SYNTHESIS

Enteral nutrition was associated with a significantly lower incidence of infections (relative risk 0.45; 95% confidence interval 0.26 to 0.78, P = 0.004), reduced surgical interventions to control pancreatitis (0.48, 0.22 to 1.0, P = 0.05), and a reduced length of hospital stay (mean reduction 2.9 days, 1.6 days to 4.3 days, P < 0.001). There were no significant differences in mortality (relative risk 0.66, 0.32 to 1.37, P = 0.3) or non-infectious complications (0.61, 0.31 to 1.22, P = 0.16) between the two groups of patients.

CONCLUSIONS

Enteral nutrition should be the preferred route of nutritional support in patients with acute pancreatitis.

Authors+Show Affiliations

Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA. maripe@ccm.upmc.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

15175229

Citation

Marik, Paul E., and Gary P. Zaloga. "Meta-analysis of Parenteral Nutrition Versus Enteral Nutrition in Patients With Acute Pancreatitis." BMJ (Clinical Research Ed.), vol. 328, no. 7453, 2004, p. 1407.
Marik PE, Zaloga GP. Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. BMJ. 2004;328(7453):1407.
Marik, P. E., & Zaloga, G. P. (2004). Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. BMJ (Clinical Research Ed.), 328(7453), 1407.
Marik PE, Zaloga GP. Meta-analysis of Parenteral Nutrition Versus Enteral Nutrition in Patients With Acute Pancreatitis. BMJ. 2004 Jun 12;328(7453):1407. PubMed PMID: 15175229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. AU - Marik,Paul E, AU - Zaloga,Gary P, Y1 - 2004/06/02/ PY - 2004/6/4/pubmed PY - 2004/7/13/medline PY - 2004/6/4/entrez SP - 1407 EP - 1407 JF - BMJ (Clinical research ed.) JO - BMJ VL - 328 IS - 7453 N2 - OBJECTIVE: To compare the safety and clinical outcomes of enteral and parenteral nutrition in patients with acute pancreatitis. DATA SOURCES: Medline, Embase, Cochrane controlled trials register, and citation review of relevant primary and review articles. STUDY SELECTION: Randomised controlled studies that compared enteral nutrition with parenteral nutrition in patients with acute pancreatitis. From 117 articles screened, six were identified as randomised controlled trials and were included for data extraction. DATA EXTRACTION: Six studies with 263 participants were analysed. Descriptive and outcome data were extracted. Main outcome measures were infections, complications other than infections, operative interventions, length of hospital stay, and mortality. The meta-analysis was performed with the random effects model. DATA SYNTHESIS: Enteral nutrition was associated with a significantly lower incidence of infections (relative risk 0.45; 95% confidence interval 0.26 to 0.78, P = 0.004), reduced surgical interventions to control pancreatitis (0.48, 0.22 to 1.0, P = 0.05), and a reduced length of hospital stay (mean reduction 2.9 days, 1.6 days to 4.3 days, P < 0.001). There were no significant differences in mortality (relative risk 0.66, 0.32 to 1.37, P = 0.3) or non-infectious complications (0.61, 0.31 to 1.22, P = 0.16) between the two groups of patients. CONCLUSIONS: Enteral nutrition should be the preferred route of nutritional support in patients with acute pancreatitis. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/15175229/Meta_analysis_of_parenteral_nutrition_versus_enteral_nutrition_in_patients_with_acute_pancreatitis_ L2 - https://www.bmj.com/lookup/pmidlookup?view=long&amp;pmid=15175229 DB - PRIME DP - Unbound Medicine ER -