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Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC Study.
Prostate Cancer Prostatic Dis. 2004; 7(2):165-9.PC

Abstract

INTRODUCTION

The African-American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit African-American families fulfilling very stringent criteria of four or more members diagnosed with prostate cancer at a combined age at diagnosis of 65 years or less. This report describes the clinical characteristics of a sample of affected AAHPC family members.

METHODS

In all, 92 African-American families were recruited into the study between 1998 and 2002. Complete clinical data including age and PSA at diagnosis, number of affected per family, stage, grade, and primary treatment were available on 154 affected males. Nonparametric Wilcoxon two-sample tests and Fisher's exact test (two-tailed), were performed to compare families with 4-6 and >6 affected males with respect to clinical characteristics.

RESULTS

The mean number of affected men per family was 5.5, with a mean age at diagnosis of 61.0 (+/-8.4) years. Age at diagnosis, PSA and Gleason score did not show significant differences between the two groups of families. Based on the Gleason score, 77.2% of affected males had favorable histology. Significantly, there were marked differences between the two groups in the frequency of node-positive disease (P=0.01) and distant metastases (P=0.0001). Radical prostatectomy was the preferred primary therapy for 66.2% of all affected men followed by 20.8% who chose radiation therapy.

CONCLUSIONS

Our findings suggest that affected males who carry the highest load of genetic factors are at the highest risk for early dissemination of disease, thus efforts at early diagnosis and aggressive therapeutic approaches may be warranted in these families. Since the primary therapy choices in our study favored definitive treatment (87.0%) when compared to the 1983 and 1995 SEER data in which 28 and 64% received definitive treatment, respectively, it appears that affected African-American men in multiplex families may be demonstrating the reported psycho-social impact of family history on screening practices and treatment decisions for prostate cancer.

Authors+Show Affiliations

National Human Genome Center, Howard University, Washington, DC, USA. cahaghotu@howard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15175665

Citation

Ahaghotu, C, et al. "Clinical Characteristics of African-American Men With Hereditary Prostate Cancer: the AAHPC Study." Prostate Cancer and Prostatic Diseases, vol. 7, no. 2, 2004, pp. 165-9.
Ahaghotu C, Baffoe-Bonnie A, Kittles R, et al. Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC Study. Prostate Cancer Prostatic Dis. 2004;7(2):165-9.
Ahaghotu, C., Baffoe-Bonnie, A., Kittles, R., Pettaway, C., Powell, I., Royal, C., Wang, H., Vijayakumar, S., Bennett, J., Hoke, G., Mason, T., Bailey-Wilson, J., Boykin, W., Berg, K., Carpten, J., Weinrich, S., Trent, J., Dunston, G., & Collins, F. (2004). Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC Study. Prostate Cancer and Prostatic Diseases, 7(2), 165-9.
Ahaghotu C, et al. Clinical Characteristics of African-American Men With Hereditary Prostate Cancer: the AAHPC Study. Prostate Cancer Prostatic Dis. 2004;7(2):165-9. PubMed PMID: 15175665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of African-American men with hereditary prostate cancer: the AAHPC Study. AU - Ahaghotu,C, AU - Baffoe-Bonnie,A, AU - Kittles,R, AU - Pettaway,C, AU - Powell,I, AU - Royal,C, AU - Wang,H, AU - Vijayakumar,S, AU - Bennett,J, AU - Hoke,G, AU - Mason,T, AU - Bailey-Wilson,J, AU - Boykin,W, AU - Berg,K, AU - Carpten,J, AU - Weinrich,S, AU - Trent,J, AU - Dunston,G, AU - Collins,F, PY - 2004/6/4/pubmed PY - 2004/9/15/medline PY - 2004/6/4/entrez SP - 165 EP - 9 JF - Prostate cancer and prostatic diseases JO - Prostate Cancer Prostatic Dis. VL - 7 IS - 2 N2 - INTRODUCTION: The African-American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit African-American families fulfilling very stringent criteria of four or more members diagnosed with prostate cancer at a combined age at diagnosis of 65 years or less. This report describes the clinical characteristics of a sample of affected AAHPC family members. METHODS: In all, 92 African-American families were recruited into the study between 1998 and 2002. Complete clinical data including age and PSA at diagnosis, number of affected per family, stage, grade, and primary treatment were available on 154 affected males. Nonparametric Wilcoxon two-sample tests and Fisher's exact test (two-tailed), were performed to compare families with 4-6 and >6 affected males with respect to clinical characteristics. RESULTS: The mean number of affected men per family was 5.5, with a mean age at diagnosis of 61.0 (+/-8.4) years. Age at diagnosis, PSA and Gleason score did not show significant differences between the two groups of families. Based on the Gleason score, 77.2% of affected males had favorable histology. Significantly, there were marked differences between the two groups in the frequency of node-positive disease (P=0.01) and distant metastases (P=0.0001). Radical prostatectomy was the preferred primary therapy for 66.2% of all affected men followed by 20.8% who chose radiation therapy. CONCLUSIONS: Our findings suggest that affected males who carry the highest load of genetic factors are at the highest risk for early dissemination of disease, thus efforts at early diagnosis and aggressive therapeutic approaches may be warranted in these families. Since the primary therapy choices in our study favored definitive treatment (87.0%) when compared to the 1983 and 1995 SEER data in which 28 and 64% received definitive treatment, respectively, it appears that affected African-American men in multiplex families may be demonstrating the reported psycho-social impact of family history on screening practices and treatment decisions for prostate cancer. SN - 1365-7852 UR - https://www.unboundmedicine.com/medline/citation/15175665/Clinical_characteristics_of_African_American_men_with_hereditary_prostate_cancer:_the_AAHPC_Study_ L2 - http://dx.doi.org/10.1038/sj.pcan.4500719 DB - PRIME DP - Unbound Medicine ER -