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Metabolic syndrome and its contribution to coronary artery disease in non-diabetic subjects.
J Formos Med Assoc. 2004 Apr; 103(4):317-20.JF

Abstract

BACKGROUND AND PURPOSE

People with the metabolic syndrome are at increased risk for developing diabetes mellitus and coronary artery disease (CAD). This study assessed the 5 risk factors of metabolic syndrome in non-diabetic individuals with angiographically-documented CAD.

METHODS

To estimate the CAD risk associated with metabolic syndrome, we examined the 5 components of metabolic syndrome, defined by the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III, including blood pressure (> or = 130/85 mm Hg), fasting glucose (> or = 110 mg/dL), fasting triglycerides (> or = 150 mg/dL), high-density lipoprotein (HDL) cholesterol level (men < 40 mg/dL; women < 50 mg/dL), and abdominal obesity (waist circumference defined by the Department of Health, Taiwan: men > 90 cm; women > 80 cm) among 139 non-diabetic patients with angiographically-documented CAD and 139 age- and gender-matched non-diabetic control subjects.

RESULTS

Metabolic syndrome was found to be more prevalent in subjects with CAD than subjects without CAD (51.8% vs 18.7%; p < 0.001). Multiple logistic regression analysis showed that hypertension was the strongest predictor of CAD, followed by higher fasting glucose and lowered HDL cholesterol. These 5 factors accounted for 41.3% of total risk for CAD without diabetes.

CONCLUSIONS

Our data revealed that the prevalence of metabolic syndrome was higher in this group of patients with angiographically-diagnosed CAD without diabetes than in controls.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15175831

Citation

Lin, Rong-Tsung, et al. "Metabolic Syndrome and Its Contribution to Coronary Artery Disease in Non-diabetic Subjects." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 103, no. 4, 2004, pp. 317-20.
Lin RT, Lee WJ, Jeng CY, et al. Metabolic syndrome and its contribution to coronary artery disease in non-diabetic subjects. J Formos Med Assoc. 2004;103(4):317-20.
Lin, R. T., Lee, W. J., Jeng, C. Y., Sheu, W. H., & Chen, Y. T. (2004). Metabolic syndrome and its contribution to coronary artery disease in non-diabetic subjects. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 103(4), 317-20.
Lin RT, et al. Metabolic Syndrome and Its Contribution to Coronary Artery Disease in Non-diabetic Subjects. J Formos Med Assoc. 2004;103(4):317-20. PubMed PMID: 15175831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and its contribution to coronary artery disease in non-diabetic subjects. AU - Lin,Rong-Tsung, AU - Lee,Wen-Jane, AU - Jeng,Chii-Yeng, AU - Sheu,Wayne Huey-Herng, AU - Chen,Ying-Tsung, PY - 2004/6/4/pubmed PY - 2004/8/6/medline PY - 2004/6/4/entrez SP - 317 EP - 20 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 103 IS - 4 N2 - BACKGROUND AND PURPOSE: People with the metabolic syndrome are at increased risk for developing diabetes mellitus and coronary artery disease (CAD). This study assessed the 5 risk factors of metabolic syndrome in non-diabetic individuals with angiographically-documented CAD. METHODS: To estimate the CAD risk associated with metabolic syndrome, we examined the 5 components of metabolic syndrome, defined by the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III, including blood pressure (> or = 130/85 mm Hg), fasting glucose (> or = 110 mg/dL), fasting triglycerides (> or = 150 mg/dL), high-density lipoprotein (HDL) cholesterol level (men < 40 mg/dL; women < 50 mg/dL), and abdominal obesity (waist circumference defined by the Department of Health, Taiwan: men > 90 cm; women > 80 cm) among 139 non-diabetic patients with angiographically-documented CAD and 139 age- and gender-matched non-diabetic control subjects. RESULTS: Metabolic syndrome was found to be more prevalent in subjects with CAD than subjects without CAD (51.8% vs 18.7%; p < 0.001). Multiple logistic regression analysis showed that hypertension was the strongest predictor of CAD, followed by higher fasting glucose and lowered HDL cholesterol. These 5 factors accounted for 41.3% of total risk for CAD without diabetes. CONCLUSIONS: Our data revealed that the prevalence of metabolic syndrome was higher in this group of patients with angiographically-diagnosed CAD without diabetes than in controls. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/15175831/Metabolic_syndrome_and_its_contribution_to_coronary_artery_disease_in_non_diabetic_subjects_ L2 - https://medlineplus.gov/metabolicsyndrome.html DB - PRIME DP - Unbound Medicine ER -