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Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies.
Arch Gynecol Obstet 2005; 271(3):212-7AG

Abstract

OBJECTIVE

The objective was to assess the status of essential trace elements such as copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies at term and to compare the data with a control group. Fetal-maternal ratios of the elements and copper:zinc ratio were also computed in the control and study populations.

METHODOLOGY

Samples from maternal vein, umbilical artery and umbilical vein of diabetic and control women were collected at the time of spontaneous delivery or cesarean section and activities of trace elements evaluated by atomic absorption spectrophotometry.

RESULTS

Cu, Fe, Mo, Se and Zn concentrations in maternal venous blood averaged 2,156, 2,020, 13, 102 and 656 microg/l in control women (n=17) while in the diabetic group (n=14), the corresponding values for the trace elements averaged 3,135, 3,675, 15, 85 and 628 microg/l respectively. Values for copper and molybdenum were significantly higher (p<0.05) in the study group compared to control while those of zinc, iron and selenium were not significantly different (p>0.05). Iron and molybdenum values were significantly higher (p<0.05) and that of zinc significantly lower (p<0.05) in umbilical arterial samples of diabetic group compared to controls. In the case of molybdenum, copper the values were significantly higher (p<0.05) in umbilical venous samples of diabetic group compared to that of control. Significant differences in Cu:Zn ratio of maternal venous and umbilical samples and fetal-maternal ratios of some elements were noted between control and study group as well.

CONCLUSION

We speculate that altered status of some essential trace elements and altered antioxidant mineral ratio observed in insulin dependent diabetic patients could have deleterious influences on the health of the mother as well as the fetus and newborn.

Authors+Show Affiliations

Obstetrics and Gynecology Department, Faculty of Medicine, University of Kuwait, PO Box 24923, 13110 Safat, Kuwait. DR.EYAD@lycos.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15175885

Citation

Al-Saleh, Eyad, et al. "Maternal-fetal Status of Copper, Iron, Molybdenum, Selenium and Zinc in Insulin-dependent Diabetic Pregnancies." Archives of Gynecology and Obstetrics, vol. 271, no. 3, 2005, pp. 212-7.
Al-Saleh E, Nandakumaran M, Al-Shammari M, et al. Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies. Arch Gynecol Obstet. 2005;271(3):212-7.
Al-Saleh, E., Nandakumaran, M., Al-Shammari, M., Makhseed, M., Sadan, T., & Harouny, A. (2005). Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies. Archives of Gynecology and Obstetrics, 271(3), pp. 212-7.
Al-Saleh E, et al. Maternal-fetal Status of Copper, Iron, Molybdenum, Selenium and Zinc in Insulin-dependent Diabetic Pregnancies. Arch Gynecol Obstet. 2005;271(3):212-7. PubMed PMID: 15175885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies. AU - Al-Saleh,Eyad, AU - Nandakumaran,Moorkath, AU - Al-Shammari,Majed, AU - Makhseed,Maasoumah, AU - Sadan,Teena, AU - Harouny,Assem, Y1 - 2004/06/03/ PY - 2003/07/02/received PY - 2004/03/08/accepted PY - 2004/6/4/pubmed PY - 2006/8/19/medline PY - 2004/6/4/entrez SP - 212 EP - 7 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 271 IS - 3 N2 - OBJECTIVE: The objective was to assess the status of essential trace elements such as copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies at term and to compare the data with a control group. Fetal-maternal ratios of the elements and copper:zinc ratio were also computed in the control and study populations. METHODOLOGY: Samples from maternal vein, umbilical artery and umbilical vein of diabetic and control women were collected at the time of spontaneous delivery or cesarean section and activities of trace elements evaluated by atomic absorption spectrophotometry. RESULTS: Cu, Fe, Mo, Se and Zn concentrations in maternal venous blood averaged 2,156, 2,020, 13, 102 and 656 microg/l in control women (n=17) while in the diabetic group (n=14), the corresponding values for the trace elements averaged 3,135, 3,675, 15, 85 and 628 microg/l respectively. Values for copper and molybdenum were significantly higher (p<0.05) in the study group compared to control while those of zinc, iron and selenium were not significantly different (p>0.05). Iron and molybdenum values were significantly higher (p<0.05) and that of zinc significantly lower (p<0.05) in umbilical arterial samples of diabetic group compared to controls. In the case of molybdenum, copper the values were significantly higher (p<0.05) in umbilical venous samples of diabetic group compared to that of control. Significant differences in Cu:Zn ratio of maternal venous and umbilical samples and fetal-maternal ratios of some elements were noted between control and study group as well. CONCLUSION: We speculate that altered status of some essential trace elements and altered antioxidant mineral ratio observed in insulin dependent diabetic patients could have deleterious influences on the health of the mother as well as the fetus and newborn. SN - 0932-0067 UR - https://www.unboundmedicine.com/medline/citation/15175885/Maternal_fetal_status_of_copper_iron_molybdenum_selenium_and_zinc_in_insulin_dependent_diabetic_pregnancies_ L2 - https://dx.doi.org/10.1007/s00404-004-0636-8 DB - PRIME DP - Unbound Medicine ER -