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Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers.
Psychoneuroendocrinology. 2004 Aug; 29(7):851-60.P

Abstract

Ghrelin, the endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor and some GHSs exert different effects on sleep electroencephalogram (EEG) and sleep-related hormone secretion in humans. Similar to GH-releasing hormone (GHRH) ghrelin promotes slow-wave sleep in humans, whereas GH-releasing peptide-6 (GHRP-6) enhances stage 2 nonrapid-eye movement sleep (NREMS). As GHRP-6, hexarelin is a synthetic GHS. Hexarelin is superior to GHRH and GHRP-6 in stimulating GH release. The influence of hexarelin on sleep-endocrine activity and the immune system is unknown. We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h. Following hexarelin, stage 4 sleep during the first half of the night, and EEG delta power during the total night decreased significantly. Significant increases of the concentrations of GH and prolactin during the total night, and of ACTH and of cortisol during the first half of the night were found. Leptin levels, TNF-alpha and soluble TNF receptors remained unchanged. We hypothesize that sleep is impaired after hexarelin since the GHRH/corticotropin-releasing hormone (CRH) ratio is changed in favour of CRH. There are no hints for an interaction of hexarelin and the immune system.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, D-80804 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15177700

Citation

Frieboes, Ralf-Michael, et al. "Hexarelin Decreases Slow-wave Sleep and Stimulates the Secretion of GH, ACTH, Cortisol and Prolactin During Sleep in Healthy Volunteers." Psychoneuroendocrinology, vol. 29, no. 7, 2004, pp. 851-60.
Frieboes RM, Antonijevic IA, Held K, et al. Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. Psychoneuroendocrinology. 2004;29(7):851-60.
Frieboes, R. M., Antonijevic, I. A., Held, K., Murck, H., Pollmächer, T., Uhr, M., & Steiger, A. (2004). Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. Psychoneuroendocrinology, 29(7), 851-60.
Frieboes RM, et al. Hexarelin Decreases Slow-wave Sleep and Stimulates the Secretion of GH, ACTH, Cortisol and Prolactin During Sleep in Healthy Volunteers. Psychoneuroendocrinology. 2004;29(7):851-60. PubMed PMID: 15177700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. AU - Frieboes,Ralf-Michael, AU - Antonijevic,Irina A, AU - Held,Katja, AU - Murck,Harald, AU - Pollmächer,Thomas, AU - Uhr,Manfred, AU - Steiger,Axel, PY - 2003/02/07/received PY - 2003/06/30/revised PY - 2003/07/25/accepted PY - 2004/6/5/pubmed PY - 2004/9/24/medline PY - 2004/6/5/entrez SP - 851 EP - 60 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 29 IS - 7 N2 - Ghrelin, the endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor and some GHSs exert different effects on sleep electroencephalogram (EEG) and sleep-related hormone secretion in humans. Similar to GH-releasing hormone (GHRH) ghrelin promotes slow-wave sleep in humans, whereas GH-releasing peptide-6 (GHRP-6) enhances stage 2 nonrapid-eye movement sleep (NREMS). As GHRP-6, hexarelin is a synthetic GHS. Hexarelin is superior to GHRH and GHRP-6 in stimulating GH release. The influence of hexarelin on sleep-endocrine activity and the immune system is unknown. We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h. Following hexarelin, stage 4 sleep during the first half of the night, and EEG delta power during the total night decreased significantly. Significant increases of the concentrations of GH and prolactin during the total night, and of ACTH and of cortisol during the first half of the night were found. Leptin levels, TNF-alpha and soluble TNF receptors remained unchanged. We hypothesize that sleep is impaired after hexarelin since the GHRH/corticotropin-releasing hormone (CRH) ratio is changed in favour of CRH. There are no hints for an interaction of hexarelin and the immune system. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/15177700/Hexarelin_decreases_slow_wave_sleep_and_stimulates_the_secretion_of_GH_ACTH_cortisol_and_prolactin_during_sleep_in_healthy_volunteers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306453003001525 DB - PRIME DP - Unbound Medicine ER -