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Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.
Regul Pept. 2004 Aug 15; 120(1-3):53-8.RP

Abstract

Recent studies showed that oxytocin and opioid peptides play important roles in pain modulation at different levels in the central nervous system. The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats. The results showed that: (1) intracerebroventricular injection of oxytocin induced dose-dependent increases in hindpaw withdrawal latencies (HWL) to noxious thermal and mechanical stimulation in rats. (2) The antinociceptive effect of oxytocin was attenuated dose-dependently by intracerebroventricular injection of naloxone, indicating an involvement of opioid system in the oxytocin-induced antinociception. (3) It is interesting that the antinociceptive effect of oxytocin was attenuated by subsequent intracerebroventricular injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa-opioid antagonist nor-binaltorphimine (nor-BNI), but not the delta-opioid antagonist naltrindole. The results indicate that oxytocin plays an antinociceptive role in the brain of rats; mu- and kappa-opioid receptors, not delta-receptors, are involved in the oxytocin-induced antinociception in the central nervous system of rats.

Authors+Show Affiliations

Laboratory of Neurobiology, College of Life Sciences, and National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, PR China.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15177920

Citation

Gao, Lian, and Long-Chuan Yu. "Involvement of Opioid Receptors in the Oxytocin-induced Antinociception in the Central Nervous System of Rats." Regulatory Peptides, vol. 120, no. 1-3, 2004, pp. 53-8.
Gao L, Yu LC. Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats. Regul Pept. 2004;120(1-3):53-8.
Gao, L., & Yu, L. C. (2004). Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats. Regulatory Peptides, 120(1-3), 53-8.
Gao L, Yu LC. Involvement of Opioid Receptors in the Oxytocin-induced Antinociception in the Central Nervous System of Rats. Regul Pept. 2004 Aug 15;120(1-3):53-8. PubMed PMID: 15177920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats. AU - Gao,Lian, AU - Yu,Long-Chuan, PY - 2004/02/09/received PY - 2004/02/09/revised PY - 2004/02/10/accepted PY - 2004/6/5/pubmed PY - 2005/1/12/medline PY - 2004/6/5/entrez SP - 53 EP - 8 JF - Regulatory peptides JO - Regul Pept VL - 120 IS - 1-3 N2 - Recent studies showed that oxytocin and opioid peptides play important roles in pain modulation at different levels in the central nervous system. The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats. The results showed that: (1) intracerebroventricular injection of oxytocin induced dose-dependent increases in hindpaw withdrawal latencies (HWL) to noxious thermal and mechanical stimulation in rats. (2) The antinociceptive effect of oxytocin was attenuated dose-dependently by intracerebroventricular injection of naloxone, indicating an involvement of opioid system in the oxytocin-induced antinociception. (3) It is interesting that the antinociceptive effect of oxytocin was attenuated by subsequent intracerebroventricular injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa-opioid antagonist nor-binaltorphimine (nor-BNI), but not the delta-opioid antagonist naltrindole. The results indicate that oxytocin plays an antinociceptive role in the brain of rats; mu- and kappa-opioid receptors, not delta-receptors, are involved in the oxytocin-induced antinociception in the central nervous system of rats. SN - 0167-0115 UR - https://www.unboundmedicine.com/medline/citation/15177920/Involvement_of_opioid_receptors_in_the_oxytocin_induced_antinociception_in_the_central_nervous_system_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167011504000515 DB - PRIME DP - Unbound Medicine ER -