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Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors.
Ophthalmology. 2004 Jun; 111(6):1183-90.O

Abstract

OBJECTIVE

Narrowed retinal arterioles may independently predict cardiovascular disease. We describe a computer-assisted method to measure retinal vessel diameters from digitized fundus photographs in a large population, and examine the correlation of retinal vessel diameters between eyes and whether refractive errors affect these measurements.

DESIGN AND POPULATION

Population-based, cross-sectional study in Beaver Dam, Wisconsin (n = 4926; age, 43-84 years).

METHODS

Retinal photographs were digitized, and all arterioles and venules located in an area 0.5 to 1 disc diameter from the optic disc were measured with the aid of computer software.

MAIN OUTCOME MEASURES

Summary of retinal arteriolar and venular diameters, and the ratio of their diameters (arteriole:venule ratio [AVR]).

RESULTS

Correlation between right and left eyes was substantial for retinal arteriolar diameters (Pearson correlation coefficient, rho = 0.71) and venular diameters (rho = 0.74), and moderate for the AVR (rho = 0.49). The inverse association of higher blood pressure and smaller retinal arteriolar diameters was similar using data from either one eye or two eyes; arteriolar diameters decreased by 4.1 microm (right eyes), 4.0 microm (left eyes), and 4.0 microm (mean of both eyes) with each 10-mmHg increase in mean arterial blood pressure. A myopic refraction was associated with smaller retinal vessel diameters; arteriolar diameters decreased by 2.8 microm and venular diameters by 3.3 microm with each -1.0-diopter shift towards myopia. However, the pattern and strength of the association of blood pressure and retinal vessel diameters were not altered by variations in refractive errors.

CONCLUSIONS

There is good correlation of retinal vessel diameters between eyes. A myopic refraction is associated with smaller retinal vessel diameters. The association of retinal arteriolar diameters and blood pressure seems similar using data from either one eye or two eyes, and is minimally affected by refraction. These data suggest that measurement of retinal vessel diameters from one eye without regard to its refractive status may provide adequate information indicative of a person's retinal vessel caliber if information from two eyes and refraction is unavailable.

Authors+Show Affiliations

Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA. ophwty@nus.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15177969

Citation

Wong, Tien Yin, et al. "Computer-assisted Measurement of Retinal Vessel Diameters in the Beaver Dam Eye Study: Methodology, Correlation Between Eyes, and Effect of Refractive Errors." Ophthalmology, vol. 111, no. 6, 2004, pp. 1183-90.
Wong TY, Knudtson MD, Klein R, et al. Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology. 2004;111(6):1183-90.
Wong, T. Y., Knudtson, M. D., Klein, R., Klein, B. E., Meuer, S. M., & Hubbard, L. D. (2004). Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology, 111(6), 1183-90.
Wong TY, et al. Computer-assisted Measurement of Retinal Vessel Diameters in the Beaver Dam Eye Study: Methodology, Correlation Between Eyes, and Effect of Refractive Errors. Ophthalmology. 2004;111(6):1183-90. PubMed PMID: 15177969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. AU - Wong,Tien Yin, AU - Knudtson,Michael D, AU - Klein,Ronald, AU - Klein,Barbara E K, AU - Meuer,Stacy M, AU - Hubbard,Larry D, PY - 2003/04/14/received PY - 2003/09/25/accepted PY - 2004/6/5/pubmed PY - 2004/6/29/medline PY - 2004/6/5/entrez SP - 1183 EP - 90 JF - Ophthalmology JO - Ophthalmology VL - 111 IS - 6 N2 - OBJECTIVE: Narrowed retinal arterioles may independently predict cardiovascular disease. We describe a computer-assisted method to measure retinal vessel diameters from digitized fundus photographs in a large population, and examine the correlation of retinal vessel diameters between eyes and whether refractive errors affect these measurements. DESIGN AND POPULATION: Population-based, cross-sectional study in Beaver Dam, Wisconsin (n = 4926; age, 43-84 years). METHODS: Retinal photographs were digitized, and all arterioles and venules located in an area 0.5 to 1 disc diameter from the optic disc were measured with the aid of computer software. MAIN OUTCOME MEASURES: Summary of retinal arteriolar and venular diameters, and the ratio of their diameters (arteriole:venule ratio [AVR]). RESULTS: Correlation between right and left eyes was substantial for retinal arteriolar diameters (Pearson correlation coefficient, rho = 0.71) and venular diameters (rho = 0.74), and moderate for the AVR (rho = 0.49). The inverse association of higher blood pressure and smaller retinal arteriolar diameters was similar using data from either one eye or two eyes; arteriolar diameters decreased by 4.1 microm (right eyes), 4.0 microm (left eyes), and 4.0 microm (mean of both eyes) with each 10-mmHg increase in mean arterial blood pressure. A myopic refraction was associated with smaller retinal vessel diameters; arteriolar diameters decreased by 2.8 microm and venular diameters by 3.3 microm with each -1.0-diopter shift towards myopia. However, the pattern and strength of the association of blood pressure and retinal vessel diameters were not altered by variations in refractive errors. CONCLUSIONS: There is good correlation of retinal vessel diameters between eyes. A myopic refraction is associated with smaller retinal vessel diameters. The association of retinal arteriolar diameters and blood pressure seems similar using data from either one eye or two eyes, and is minimally affected by refraction. These data suggest that measurement of retinal vessel diameters from one eye without regard to its refractive status may provide adequate information indicative of a person's retinal vessel caliber if information from two eyes and refraction is unavailable. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/15177969/Computer_assisted_measurement_of_retinal_vessel_diameters_in_the_Beaver_Dam_Eye_Study:_methodology_correlation_between_eyes_and_effect_of_refractive_errors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(04)00124-1 DB - PRIME DP - Unbound Medicine ER -